公开(公告)号：EP4053277A1

公开(公告)日：2022-09-07

申请号：EP21213766.5

申请日：2016-12-26

申请人： Novartis AG ,  Intellia Therapeutics, Inc.

发明人： BOITANO, Anthony Edward ,  COOKE, Michael ,  KLICKSTEIN, Lloyd B. ,  LESCARBEAU, Reynald ,  MICKANIN, Craig Stephen ,  MULUMBA, Kabungo ,  POLICE, Seshidhar Reddy ,  SNEAD, Jennifer ,  STEVENSON, Susan C. ,  STEWART, Morag ,  YANG, Yi

IPC分类号： C12N15/113

摘要： The present invention is directed to genome editing systems, reagents and methods for the treatment of hemoglobinopathies.

公开(公告)号：EP3577223A1

公开(公告)日：2019-12-11

申请号：EP18708204.5

申请日：2018-02-05

申请人： Novartis AG ,  Intellia Therapeutics, Inc.

发明人： MICKANIN, Craig Stephen ,  SCHMEDT, Christian ,  SNEAD, Jennifer ,  STEVENSON, Susan C. ,  YANG, Yi

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61P7/00

公开(公告)号：EP4359527A2

公开(公告)日：2024-05-01

申请号：EP22738005.2

申请日：2022-06-22

申请人： Novartis AG

发明人： BELEW, Muluken Shambel ,  COBB, Jennifer Stroka ,  RUSS, Carsten ,  SIGOILLOT, Frederic ,  STEVENSON, Susan C. ,  TING, Pamela Yf

IPC分类号： C12N15/113 ,  A61K31/7088 ,  A61P7/00

CPC分类号： C12N15/113 ,  C12N2310/2020170501

公开(公告)号：EP2113030A2

公开(公告)日：2009-11-04

申请号：EP08709005.6

申请日：2008-02-14

申请人： Novartis AG

发明人： CHEN, Jian ,  GARZA, Dan ,  LI, Hao ,  STEVENSON, Susan C. ,  WU, Zhidan

IPC分类号： C12N15/12 ,  C07K14/435 ,  C12Q1/68 ,  G01N33/50 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713

CPC分类号： G01N33/5079 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/12 ,  C12N2330/31 ,  G01N2800/52

摘要： The invention discloses suitable gene and polypeptide targets for the development of new therapeutics to treat, prevent or ameliorate conditions associated with mitochondrial dysfunction. The invention also relates to methods to treat, prevent or ameliorate said conditions and pharmaceutical compositions therefor, as well as to a method to identify compounds with therapeutic usefulness to treat conditions associated with mitochondrial dysfunction.

公开(公告)号：EP2015777B1

公开(公告)日：2010-08-18

申请号：EP07783060.2

申请日：2007-05-02

申请人： Novartis AG

发明人： RANGWALA, Shamina M. ,  STEVENSON, Susan C. ,  WU, Zhidan

IPC分类号： A61K45/00

CPC分类号： A61K31/00

公开(公告)号：EP2015777A2

公开(公告)日：2009-01-21

申请号：EP07783060.2

申请日：2007-05-02

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： RANGWALA, Shamina M. ,  STEVENSON, Susan C. ,  WU, Zhidan

IPC分类号： A61K45/00

CPC分类号： A61K31/00

摘要： Use of a ERRy agonist or pharmaceutically acceptable salt thereof, for the prevention, delay of progression or the treatment of diabetes, insulin resistance, metabolic disease/metabolic syndrome, dyslipidemia, obesity, overweight, Neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease or improvement of exercise endurance capacity.