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公开(公告)号：EP2556375A1
公开(公告)日：2013-02-13
申请号：EP11713692.9
申请日：2011-04-07
申请人： Universität Duisburg-Essen , Friedrich-Alexander-Universität Erlangen-Nürnberg , Zentralinstitut Für Seelische Gesundheit , Universitätsklinikum Erlangen
发明人： ESSELMANN, Hermann , GRÖMER, Teja, W. , KORNHUBER, Johannes , LEWCZUK, Piotr , MALER, Juan, Manuel , WILTFANG, Jens
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/4709
摘要： The invention relates to the use of at least one quantitative ratio (quotient) of two amyloid beta peptidea (A beta; Aß) which are different from one another in a sample of a bodily fluid of a test subject and/or patient in order to determine the probability (risk) of said test subject and/or patient suffering Alzheimer's disease (Morbus Alzheimer, AD) and/or to determine (diagnose) suffering from an early stage of Alzheimer's disease, wherein the amyloid beta peptides are selected from (a) Aß(1-42), (b) Aß(2-40) and (c) Aß(2-42) and wherein the quantitative ratio of (a) / (b) or vice versa and/or of (a) / (c) or vice versa is formed. The invention also relates to a corresponding method and to a kit for use in this connection.
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公开(公告)号：EP2095128B1
公开(公告)日：2013-10-02
申请号：EP07846655.4
申请日：2007-11-19
申请人： Friedrich-Alexander-Universität Erlangen-Nürnberg , Georg-August-Universität Göttingen - Stiftung Öffentlichen Rechts/Universitätsmedizin
发明人： BIBL, Mirko , MOLLENHAUER, Brit , WILTFANG, Jens , ESSELMANN, Hermann , LEWCZUK, Piotr , KORNHUBER, Johannes
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2871
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公开(公告)号：EP2095128A1
公开(公告)日：2009-09-02
申请号：EP07846655.4
申请日：2007-11-19
申请人： Friedrich-Alexander-Universität Erlangen-Nürnberg , Georg-August-Universität Göttingen - Stiftung Öffentlichen Rechts/Universitätsmedizin
发明人： BIBL, Mirko , MOLLENHAUER, Brit , WILTFANG, Jens , ESSELMANN, Hermann , LEWCZUK, Piotr , KORNHUBER, Johannes
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2871
摘要： In an ex vivo method of differentially diagnosing dementias which include vascular dementias and/or frontotemporal lobe degenerations at least one carboxy-terminally truncated amyloid β peptide selected from the group consisting of Aβ1 -38, Aβ1-37 and Aβ1-39 is used as a biomarker in a body fluid of a patient.
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公开(公告)号：EP1620733A1
公开(公告)日：2006-02-01
申请号：EP04727542.5
申请日：2004-04-15
IPC分类号： G01N33/68
CPC分类号： G01N33/6848 , G01N33/6851 , G01N33/6896 , G01N2800/2821
摘要： A method of diagnosis of Alzheimer's disease comprises the step of determining an amount of at least one species in a body fluid or a tissue homogenate sample which has been obtained from a patient. The at least one species is selected from a group of species having molecular masses in a range of 3870 to 3895 Da (Abeta) , 4520 to 4545 Da (Abeta 34) , 4802 to 4836 Da (Abeta 2-46 or Abeta 1-45) , 4837 to 4871 Da (Abeta 3-47) and 7720 to 7790 Da, respectively.
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5.发明公开BIOSENSOR FOR CONFORMATION AND SECONDARY STRUCTURE ANALYSIS 审中-公开生物传感器ZUR KONFORMATIONSEKUNDÄRENSTRUKTURANALYSE
公开(公告)号：EP3105589A1
公开(公告)日：2016-12-21
申请号：EP15704002.3
申请日：2015-02-12
发明人： GERWERT, Klaus , WILTFANG, Jens , OLLESCH, Julian , NABERS, Andreas , SCHARTNER, Jonas , KÖTTING, Carsten
IPC分类号： G01N33/543 , G01N33/553 , G01N21/35 , G01N21/55
CPC分类号： G01N21/3577 , G01N21/05 , G01N21/552 , G01N21/6428 , G01N21/6458 , G01N33/6896 , G01N2021/6421 , G01N2800/2821 , G01N2800/2835
摘要： Provided herein is a biosensor for conformation and secondary structure analysis, notably for the direct non-invasive qualitative secondary structure analysis of a single selected protein within a complex mixture, as e.g. a body fluid, by vibrational spectroscopic methods. For the analysis it is not required that the selected substance be isolated, concentrated, or pretreated by a special preparative procedure.
摘要翻译： 本文提供了用于构象和二级结构分析的生物传感器，特别是用于复杂混合物内单个选定蛋白质的直接非侵入性定性二级结构分析。 体液，通过振动光谱法。 对于分析，不要求所选物质通过特殊的制备方法进行分离，浓缩或预处理。
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