公开(公告)号：EP3494114A1

公开(公告)日：2019-06-12

申请号：EP17758056.0

申请日：2017-08-02

申请人： Friedrich-Alexander-Universität Erlangen-Nürnberg ,  Universitätsklinikum Erlangen

发明人： PRANTE, Olaf ,  KUWERT, Torsten ,  GMEINER, Peter ,  BANERJEE, Ashutosh ,  MASCHAUER, Simone

IPC分类号： C07D403/14 ,  C07F5/00 ,  A61K51/04 ,  A61P35/00

公开(公告)号：EP3964497A1

公开(公告)日：2022-03-09

申请号：EP20194568.0

申请日：2020-09-04

申请人： Friedrich-Alexander-Universität Erlangen-Nürnberg

发明人： GMEINER, Peter ,  HUEBNER, Harald ,  HETZER, Florian

IPC分类号： C07C275/24 ,  C07C275/26 ,  C07D333/74 ,  A61P25/36 ,  A61K31/36

摘要： The present invention relates to a compound of the following formula (I) or (II), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof:

The invention furthermore relates to a pharmaceutical composition comprising the compound having formula (I) or (II) and optionally one or more pharmaceutically acceptable excipient(s) and/or carrier(s), as well as to these compounds for use in the treatment, amelioration or prevention of pain, opioid overdose, addictions, neuropsychiatric disorders, Prader-Willi Syndrome, gastrointestinal disorders, skin disorders, dyspnea, headache and/or temporomandibular joint dysfunction, including methods of treating, ameliorating or preventing pain involving administering to a patient in need thereof an effective amount of the compound having formula (I) or (II).

公开(公告)号：EP3668852A1

公开(公告)日：2020-06-24

申请号：EP18769909.5

申请日：2018-08-17

申请人： The Regents of the University of California ,  The Board of Trustees of the Leland Stanford Junior University ,  Friedrich-Alexander-Universität Erlangen-Nürnberg

发明人： SHOICHET, Brian, K. ,  LEVIT, Anat ,  MANGLIK, Aashish ,  KOBILKA, Brian ,  GMEINER, Peter ,  HÜBNER, Harald ,  DENGLER, Daniela, Gisela

IPC分类号： C07D333/20 ,  A61K31/381 ,  C07C275/06 ,  C07C225/00 ,  C07C233/00 ,  A61P25/24 ,  A61P25/04

公开(公告)号：EP4426287A1

公开(公告)日：2024-09-11

申请号：EP22891077.4

申请日：2022-11-04

申请人： The Regents of the University of California ,  Friedrich-Alexander-Universität Erlangen-Nürnberg ,  Chinese University of Hong Kong, Shenzhen

发明人： SHOICHET, Brian, K. ,  FINK, Elissa, A. ,  BASBAUM, Allan, J. ,  BRAZ, Joao, M. ,  GMEINER, Peter ,  HUBNER, Harald ,  SEEMANN, Philipp ,  PFEIFFER, Tara ,  DU, Yang ,  XU, Jun

IPC分类号： A61K31/33 ,  A61K31/395 ,  A61K31/40

CPC分类号： A61K31/4409 ,  A61K31/4725 ,  A61K31/4375 ,  A61K31/4709 ,  A61K45/06 ,  A61K31/195 ,  A61K31/445 ,  C07D409/12 ,  C07D401/12 ,  C07D401/04 ,  C07D213/74 ,  C07D213/68 ,  C07D211/70 ,  C07D405/04 ,  C07D471/04 ,  C07D417/04

公开(公告)号：EP3565543A1

公开(公告)日：2019-11-13

申请号：EP18736501.0

申请日：2018-01-05

申请人： The Regents of the University of California ,  Friedrich-Alexander-Universität Erlangen-Nürnberg ,  The Board of Trustees of the Leland Stanford Junior University ,  University Of North Carlirona, Chapel Hill

发明人： SHOICHET, Brian, K. ,  GMEINER, Peter ,  HÜBNER, Harald ,  ROTH, Bryan, L. ,  DENGLER, Danniela, Gisela ,  MANGLIK, Aashish ,  KOBILKA, Brian

IPC分类号： A61K31/16 ,  A61K31/17

公开(公告)号：EP3319444A1

公开(公告)日：2018-05-16

申请号：EP16821843.6

申请日：2016-06-30

申请人： The Regents of the University of California ,  Friedrich-Alexander-Universität Erlangen-Nürnberg ,  The Board of Trustees of the Leland Stanford Junior University ,  The University Of North Carolina At Chapel Hill

发明人： ROTH, Bryan, L. ,  DENGLER, Daniela, Gisela ,  SHOICHET, Brian, K. ,  LIN, Henry ,  GMEINER, Peter ,  MANGLIK, Aashish ,  KOBILKA, Brian

IPC分类号： A01N57/00 ,  A61K31/67

CPC分类号： C07D401/12 ,  C07C275/24 ,  C07C275/26 ,  C07C2602/08 ,  C07D207/452 ,  C07D233/16 ,  C07D249/04 ,  C07D295/125 ,  C07D333/16 ,  C07D333/20 ,  C07D333/58 ,  C07D409/12 ,  C07D471/04 ,  C07D495/04 ,  C07D498/18

摘要： Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.