公开(公告)号：EP4458797A1

公开(公告)日：2024-11-06

申请号：EP22914136.1

申请日：2022-12-08

申请人： Fudan University

发明人： MA, Shengming ,  YU, Hao ,  LIU, Qi ,  SHI, Zhangjie

IPC分类号： C07C39/04 ,  C07C49/403 ,  C07B33/00

摘要： The present invention relates to a visible-light-mediated one-step method for preparing phenol and cyclohexanone from cyclohexylbenzene (CHB). The method specifically comprises: under the irradiation of visible light, and with a hydrogen bromide solution as a catalyst and oxygen as an oxidizing agent, directly oxidizing cyclohexylbenzene in an organic solvent to break a carbon-carbon bond, so as to generate phenol and cyclohexanone. The method avoids such a process in a cyclohexylbenzene method in the prior art that cyclohexylbenzene needs to be first oxidized to obtain cyclohexylbenzene-1-hydroperoxide (1-CHBHP), then the mixture of the oxidation reaction products is treated, and then a cyclohexylbenzene peroxide is decomposed in an acidic condition to obtain phenol and cyclohexanone, and also avoids potential risks caused by the accumulation of peroxides. In addition, the method further has a great number of advantages of the operation being simple, reagents being easily available, reaction conditions being mild, easy control being achievable, the reaction being able to be scaled-up, a good selectivity being obtained, etc.

公开(公告)号：EP4353707A1

公开(公告)日：2024-04-17

申请号：EP22819201.9

申请日：2022-04-14

申请人： Fudan University

发明人： SHI, Zhangjie ,  MA, Shengming ,  LIU, Feng ,  YU, Hao ,  WANG, Changcheng ,  LIU, Qi ,  ZHANG, Zhen

IPC分类号： C07C51/265 ,  C07C63/06 ,  C07C63/331 ,  C07C45/36 ,  C07C49/67 ,  C07C49/786 ,  C07C29/50 ,  C07C31/04 ,  C07C51/215 ,  C07C53/02 ,  C07D231/12 ,  C07C27/12 ,  C07B33/00

CPC分类号： C07C51/265 ,  C07C45/36 ,  C07D231/12 ,  C07C63/06 ,  C07C29/50 ,  C07C51/215 ,  C07C27/12 ,  C07C49/67 ,  C07C49/786 ,  C07C31/04 ,  C07B33/00 ,  C07C53/02 ,  C07C63/331

摘要： The present invention belongs to the technical field of organic intermediate synthesis, and provides a method for light-promoted oxidation of a compound containing a saturated carbon-hydrogen bond, comprising: mixing a compound containing a saturated carbon-hydrogen bond with a catalyst, and oxidizing the compound containing a saturated carbon-hydrogen bond in an oxygen or air atmosphere at a temperature of 20°C to 100°C under light irradiation to generate an oxidation product. The present method is a method for the light-promoted direct oxidation of a compound containing a saturated carbon-hydrogen bond, which only requires a relatively low temperature to be carried out, has good compatibility with functional groups, short reaction time, high reaction efficiency, low reaction costs, high added value, simple operation and good safety, and is a mild, green and environmentally friendly oxidation method.