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公开(公告)号：EP1495047A2
公开(公告)日：2005-01-12
申请号：EP03709469.5
申请日：2003-04-01
发明人： TENDLER, Miriam , GARRAT, Richard, Charles , KATZ, Naftale , SIMPSON, Andrew, John, George , DE BARRIENTOS, Frank, Jefferson, Alarcon , VILAR, Mônica, Magno , ALMEIDA, Marilia, Sirianni, dos Santos
IPC分类号： C07K14/435 , A61K38/17 , G01N33/53
CPC分类号： A61K39/0003 , A61K39/00 , C07K14/4354 , C07K14/43559 , C07K2319/00 , G01N33/6893 , Y02A50/423
摘要： The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (Sm14) or related FABPs (Fatty Acid Binding Proteins), the said peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic composition and diagnostic kit using said peptide fragments.
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公开(公告)号：EP1495047B1
公开(公告)日：2012-08-29
申请号：EP03709469.5
申请日：2003-04-01
发明人： TENDLER, Miriam , GARRAT, Richard, Charles , KATZ, Naftale , SIMPSON, Andrew, John, George , DE BARRIENTOS, Frank, Jefferson, Alarcon , VILAR, Mônica, Magno , ALMEIDA, Marilia, Sirianni, dos Santos
IPC分类号： C07K14/435 , A61K38/17 , G01N33/53
CPC分类号： A61K39/0003 , A61K39/00 , C07K14/4354 , C07K14/43559 , C07K2319/00 , G01N33/6893 , Y02A50/423
摘要： The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (Sm14) or related FABPs (Fatty Acid Binding Proteins), the said peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic composition and diagnostic kit using said peptide fragments.
摘要翻译： 本发明涉及对曼氏假单胞菌（SM14）或相关FABP（脂肪酸结合蛋白）的14kDa蛋白质的特定部分的氨基酸序列具有一个或多个共有和/或相似氨基酸序列的肽片段， 肽片段用作分子的连续或不连续表位区域或模拟其生物学活性。 更具体地，本发明涉及使用肽片段构建活性肽片段，肽片段，免疫原性组合物和诊断试剂盒的方法。
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3.发明公开HELMINTH-DERIVED ANTIGENS HAVING CAPACITY OF PROVIDING PROTECTION AGAINST PARASITES 有权希勒米。然后赢得了防护抗寄生虫抗原
公开(公告)号：EP1592796A2
公开(公告)日：2005-11-09
申请号：EP04706581.8
申请日：2004-01-30
发明人： TENDLER, Miriam , KATZ, Naftale , SIMPSON, Andrew, J. , RAW, Isaias , HO, Paulo, Lee , RAMOS, Celso, Raul, Romero
CPC分类号： C07K14/43559 , A61K38/00 , A61K39/00 , G01N33/56905
摘要： The primary objective of the present invention is the development of new mutant forms of the Sm14 protein, for producing a greater production volume. The recombinant proteins here obtained were capable of providing protection against schistosome and fasciola infection. The level of protection of Sml4 recombinant proteins obtained in the present invention was similar to that reached in the parasite saline extract. The mutant proteins of the present invention have reached approximately 100% of renaturation after the heating at 80°C, different from wild forms of the Sm14 protein. Moreover, after storage for 2 months at 4°C, mutant proteins have shown smaller (3-structure loss than wild forms that have shown formation with random structure, as demonstrated by the circular dichroism analysis, indicating the success of mutations.
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4.发明授权HELMINTH-DERIVED ANTIGENS HAVING CAPACITY OF PROVIDING PROTECTION AGAINST PARASITES 有权希勒米。然后赢得了防护抗寄生虫抗原
公开(公告)号：EP1592796B1
公开(公告)日：2011-11-09
申请号：EP04706581.8
申请日：2004-01-30
发明人： TENDLER, Miriam , KATZ, Naftale , SIMPSON, Andrew, J. , RAW, Isaias , HO, Paulo, Lee , RAMOS, Celso, Raul, Romero
CPC分类号： C07K14/43559 , A61K38/00 , A61K39/00 , G01N33/56905
摘要： The primary objective of the present invention is the development of new mutant forms of the Sm14 protein, for producing a greater production volume. The recombinant proteins here obtained were capable of providing protection against schistosome and fasciola infection. The level of protection of Sml4 recombinant proteins obtained in the present invention was similar to that reached in the parasite saline extract. The mutant proteins of the present invention have reached approximately 100% of renaturation after the heating at 80°C, different from wild forms of the Sm14 protein. Moreover, after storage for 2 months at 4°C, mutant proteins have shown smaller (3-structure loss than wild forms that have shown formation with random structure, as demonstrated by the circular dichroism analysis, indicating the success of mutations.
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