摘要:
The present invention relates to a SOCS1-derived peptide for use in chronic complications of diabetes, particularly ocular, renal, nerve and vascular complications, as well as compositions containing same and isolated polynucleotides encoding same. The present invention also relates to the SOCS1-derived peptide for topical use in the treatment and/or prevention of neurodegenerative diseases of the retina, particularly in the early stages of diabetic retinopathy and other diseases of the retina in which neurodegeneration plays an essential role.
摘要:
The invention provides antibodies for use in the treatment and/or prevention of retinal diseases cursing with dysfunction of the external blood-retinal barrier. Pharmaceutical and veterinary compositions are also disclosed in which the antibodies are present. The compositions may be applied in wide spectra of ocular diseases.
摘要:
The invention relates to peptides with a sequence length from 13 to 50 amino acids, the N-terminal region of said peptides consisting in the sequence HXaa 1 EGTFTSDXaa 2 SXaa 3 Xaa 4 (SEQ ID NO: 1 ) wherein: Xaa 1 is an amino acid selected from alanine and glycine; Xaa 2 is an amino acid selected from valine and leucine; Xaa 3 is an amino acid selected from serine and lysine; Xaa 4 is an amino acid selected from tyrosine and glutamine; and Hystidine is the N-terminal residue; for use in the topical treatment and/or prevention of retinal neurodegenerative diseases, in particular diabetic retinopathy. The invention also encompasses pharmaceutical topical compositions for use in the topical treatment and/or prevention of these diseases.
摘要:
Sex hormone-binding globulin and/or any fragment thereof for use as a medicament, in particular for use in the treatment of obesity and hepatic steatosis. The invention also relates to the cosmetic use of the sex hormone-binding globulin and/or any fragment thereof for improving the bodily appearance of a mammal with subcutaneous fat herniated or accumulated within the fibrous connective tissue under the skin, in particular the cosmetic use is for cellulite.
摘要:
The invention provides antibodies for use in the treatment and/or prevention of retinal diseases cursing with dysfunction of the external blood-retinal barrier. Pharmaceutical and veterinary compositions are also disclosed in which the antibodies are present. The compositions may be applied in wide spectra of ocular diseases.
摘要:
The invention relates to dipeptidyl peptidase-4 inhibitors, including saxagliptin and sitagliptin, for use in the topical eye treatment and/or prevention of retinal neurodegenerative diseases, in particular diabetic retinopathy and its associated microvascular impairment. The invention also encompasses pharmaceutical topical eye compositions for use in the topical treatment and/or prevention of these diseases.
摘要:
The present invention relates to a SOCS1-derived peptide for use in chronic complications of diabetes, particularly ocular, renal, nerve and vascular complications, as well as compositions containing same and isolated polynucleotides encoding same. The present invention also relates to the SOCS1-derived peptide for topical use in the treatment and/or prevention of neurodegenerative diseases of the retina, particularly in the early stages of diabetic retinopathy and other diseases of the retina in which neurodegeneration plays an essential role.