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1.发明公开
公开(公告)号：EP1538200A1
公开(公告)日：2005-06-08
申请号：EP03752940.1
申请日：2003-05-22
申请人： Fushimi Pharmaceutical Company, Limited , Teikoku Seiyaku Co., Ltd. , Kagawa University , Shikoku Research Institute Incorporated , KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
发明人： IZUMORI, Ken , TOKUDA, Masaaki , ITANO, Toshifumi , MIYAMOTO, Osamu , ISHIDA, Toshihiko , MURAO, Koji , TASAKA, Taizo , MUNEUCHI, Gan , YAMAGUCHI, Fuminori , TANAKA, Terukazu , HOSSAIN, Mohammad, Akram , UEKI, Masaaki , HIROOKA, Kazuyuki , TAMINATO, Tomohiko , TSUSAKI, Keiji , TAKAHASHI, Takeo , NAGATA, Mitsuhiro , ISHIDA, Yutaka
IPC分类号： C12N5/08 , A23L1/30 , A61K7/00 , A61K31/7004
CPC分类号： A61Q19/00 , A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A61K8/60 , A61K31/7004
摘要： A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.
摘要翻译： 利用一种罕见糖的生理活性的方法，worin生理活性敏感细胞与罕见糖处理，以改变细胞的功能。 被引入生理活性敏感的细胞，并且对修饰细胞功能的影响包含组合物，如在，稀有糖类活性成分全部。 该细胞是人类细胞。 该组合物是一种功能性食品，药物或化妆品。 稀有糖类是属于醛糖和/或酮糖罕见的糖。 醛糖是D-阿洛糖，并将细胞选自癌细胞增殖抑制活性敏感的细胞和活性氧产生抑制活性敏感的细胞的选择。 所述酮糖是D-阿洛酮糖，并且所述细胞选自趋化因子分泌的抑制活性敏感的细胞，小神经胶质细胞迁移抑制活性敏感的细胞，和低血糖活性敏感的细胞的选择。
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2.发明公开MICROORGANISM CAPABLE OF PRODUCING DEOXY POLYOL DEHYDROGENASE AND UTILIZATION OF THE SAME 有权以能力生产DESOXYPOLYOL脱氢酶及其使用微生物
公开(公告)号：EP2096164A1
公开(公告)日：2009-09-02
申请号：EP07739894.9
申请日：2007-03-27
申请人： National University Corporation Kagawa University , Rare Sugar Production Technical Research Laboratories, LLC , Fushimi Pharmaceutical Company, Limited , Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo , Matsutani Chemical Industry Co., Ltd.
发明人： IZUMORI, Ken , MORIMOTO, Kenji , TAKATA, Goro , TOKUDA, Masaaki , TSUJISAKA, Yoshio , TAKESHITA, Kei , TSUSAKI, Keiji , OKUMA, Kazuhiro
CPC分类号： C12R1/01 , A61K8/60 , A61K2800/86 , A61Q19/00 , C12N9/0006 , C12P19/02
摘要： Problem: To provide a microorganism with an ability to produce deoxy polyol dehydrogenase.
Means for Resolution: A microorganism belonging to genus Enterobacter with an ability to produce a dehydrogenase for deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol. The bacterial cell IK7 of the genus Enterobacter (accession No. NITE P-271). A method for producing deoxy ketose comprising allowing a culture containing the deoxy polyol dehydrogenase obtained by the culturing of the microorganism of the invention or allowing the deoxy polyol dehydrogenase to react with a solution containing deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol to oxidize deoxy polyol to produce the corresponding deoxy ketose and then collecting the deoxy ketose. The deoxy polyol is 1-deoxy-D-allitol, while the corresponding deoxy ketose is 1-deoxy-L-psicose. Otherwise, the deoxy polyol is L-rhamnitol, while the corresponding deoxy ketose is 1-deoxy-L-fructose.摘要翻译： 问题：在生产脱氧多元醇脱氢酶的能力提供了一个微生物与。 用于解决方法：一种微生物，属于肠杆菌属的与在位置C2和C3象核糖醇或L-艾杜糖醇的以产生用于相同的结构的多元醇脱氧脱氢酶的能力。 肠杆菌属（保藏号NITE P-271）的细菌细胞IK7。 一种生产脱氧酮糖包括允许培养含有由本发明的微生物的培养或允许脱氧多元醇脱氢酶与在位置C2和C3为含有相同的结构的脱氧多羟基化合物的溶液中反应而获得的脱氧多元醇脱氢酶方法 确实核糖醇或L-艾杜糖醇的氧化脱氧多羟基化合物，以产生相应脱氧酮糖，然后收集所述脱氧酮糖。 脱氧多羟基化合物是1-脱氧-D-蒜糖醇，而相应的脱氧酮糖是1-脱氧-L-阿洛酮糖。 否则，脱氧多羟基化合物是L-rhamnitol，而相应的脱氧酮糖是1-脱氧-L-果糖。
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3.发明公开THERMOSTABLE L-RIBOSE ISOMERASE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF 有权热稳定剂L-RIBOSE-ISOMERASE，VERFAHREN ZU DEREN HERSTELLUNG UND ANWENDUNG DAVON
公开(公告)号：EP2103625A1
公开(公告)日：2009-09-23
申请号：EP07739605.9
申请日：2007-03-26
申请人： National University Corporation Kagawa University , Rare Sugar Production Technical Research Laboratories, LLC , Fushimi Pharmaceutical Company, Limited , Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo , Matsutani Chemical Industry Co., Ltd.
发明人： IZUMORI, Ken , MORIMOTO, Kenji , TAKATA, Goro , TOKUDA, Masaaki , TSUJISAKA, Yoshio , TAKESHITA, Kei , TSUSAKI, Keiji , OKUMA, Kazuhiro
IPC分类号： C07K14/195 , C12N1/20 , C12N9/90 , C12P19/24
摘要： Object: To provide a thermostable L-ribose isomerase.
Means for Resolution: The thermostable L-ribose isomerase with MW. 32,000 (by SDS-PAGE), optimal temperature of 45°C, optimal pH of pH 9. 0 (glycine-NaOH buffer), and stable physicochemical properties such as temperature stability up to 45°C during thermal treatment at pH 9.0 for 10 minutes, and with an action to isomerize L-ribose to generate L-ribulose or of inversely to isomerize L-ribulose to generate L-ribose. A conversion method between an aldose and a ketose comprising allowing the thermostable L-ribose isomerase as an enzyme derived from (1) Raoultella ornithinolytica strain MB426 (NITE BP-277) to interact with an aldose selected from L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose to isomerize the aldose to generate a ketose selected from the individually corresponding L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose or to interact with a ketose selected from L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose to isomerize the ketose to generate an aldose selected from the individually corresponding L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose.摘要翻译： 目的：提供热稳定的L-核糖异构酶。 解决方法：具有MW的热稳定的L-核糖异构酶。 32,000（通过SDS-PAGE），最适温度为45℃，pH为9.0（甘氨酸 - NaOH缓冲液）的最佳pH，以及稳定的物理化学性质，例如在pH 9.0的热处理期间高达45℃的温度稳定性为10 分钟，并且具有异构化L-核糖以产生L-核酮糖的作用或者与L-核酮糖异构化以产生L-核糖的作用。 醛糖和酮糖之间的转化方法，其包括使热稳定的L-核糖异构酶作为源自（1）鸟氨酸龙胆菌株MB426（NITE BP-277）的酶与选自L-核糖，D-赖索糖， D-山梨糖醇，D-甘露糖，L-丙氨酸和L-古洛糖醇，使醛糖异构化，产生选自单独对应的L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵芝蛋白和L- 山梨糖或与选自L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵敏糖和L-山梨糖的酮糖相互作用以使酮糖异构化以产生选自相应的L-核糖，D D-糖精，D-托洛糖，D-甘露糖，L-阿洛糖和L-古洛糖。
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4.发明授权DEOXYKETOHEXOSE ISOMERASE AND METHOD FOR PRODUCING DEOXYHEXOSE AND DERIVATIVE THEREOF USING SAME 有权DESOXYKETOHEXOSE异构酶及其制造方法脱氧己并使用此DESOXYKETOHEXOSE的衍生物
公开(公告)号：EP2161332B1
公开(公告)日：2015-04-22
申请号：EP07832172.6
申请日：2007-11-20
申请人： National University Corporation Kagawa University , Rare Sugar Production Technical Research Laboratories, LLC , Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo , Matsutani Chemical Industry Co., Ltd.
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5.发明公开DEOXYKETOHEXOSE ISOMERASE AND METHOD FOR PRODUCING DEOXYKETOHEXOSE AND DERIVATIVE THEREOF USING THE SAME 有权DESOXYKETOHEXOSE异构酶及其制造方法脱氧己并使用此DESOXYKETOHEXOSE的衍生物
公开(公告)号：EP2161332A1
公开(公告)日：2010-03-10
申请号：EP07832172.6
申请日：2007-11-20
申请人： National University Corporation Kagawa University , Rare Sugar Production Technical Research Laboratories, LLC , Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo , Matsutani Chemical Industry Co., Ltd.
发明人： IZUMORI, Ken , TOKUDA, Masaaki , FLEET, George , TSUJISAKA, Yoshio , TAKESHITA, Kei , TSUSAKI, Keiji , OKUMA, Kazuhiro
摘要： Providing 1- or 6-deoxy products corresponding to all of aldohexoses, ketohexoses and sugar alcohols, as based on Deoxy-Izumoring, as well as a method for systematically producing those products. A method for producing deoxyketohexose and a derivative thereof using a deoxyketohexose isomerase derived from Pseudomonas cichorii ST-24 (FERM BP-2736), comprising epimerizing 1-deoxy D-ketohexose or 6-deoxy D-ketohexose or 1-deoxy L-ketohexose or 6-deoxy L-ketohexose at position 3 to produce the individually corresponding 1-deoxy D-ketohexose or 6-deoxy D-ketohexose or 1-deoxy L-ketohexose or 6-deoxy L-ketohexose as an intended product.
摘要翻译： 提供了1-或6-脱氧产品对应于所有己醛糖，己酮糖和糖醇的，作为基于脱氧Izumoring，以及一种用于系统地生产这些产品。 一种用于生产deoxyketohexose方法及其使用从菊苣假单胞菌ST-24（FERM BP-2736），包括差向异构1-脱氧D-己酮糖或6-脱氧D-己酮或1-脱氧L-己酮糖或衍生的deoxyketohexose异构酶衍生物 在位置3 6-脱氧-L-己酮糖，以产生分别对应1-脱氧-D-己酮糖或6-脱氧-D-或L-己酮糖己酮糖或6-脱氧-L-己酮糖作为目的产物1-脱氧。
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公开(公告)号：EP1256346A1
公开(公告)日：2002-11-13
申请号：EP00981742.0
申请日：2000-12-15
发明人： INAMOTO, Yukiko , KAWATA, Mitsuhiro , KAWABATA, Seiichiro , NAKAYAMA, Daisuke , HISAICHI, Shin-ichi , TOKUDA, Masaaki
CPC分类号： A61K9/0014 , A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/60 , A61K31/616
摘要： External preparations for allergic dermatitis containing Aspirin alone as the active ingredient, which exert an excellent therapeutic effects on allergic dermatitis with lower side effects; and a method for treating allergic dermatitis by using these agents for external use.
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公开(公告)号：EP1249239A1
公开(公告)日：2002-10-16
申请号：EP00981741.2
申请日：2000-12-15
发明人： INAMOTO, Yukiko , KAWATA, Mitsuhiro , KAWABATA, Seiichiro , NAKAYAMA, Daisuke , HISAICHI, Shin-ichi , TOKUDA, Masaaki
CPC分类号： A61K9/0014 , A61K9/06 , A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/616 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/26
摘要： External preparations for treating pruritus containing Aspirin as an active ingredient, which exert an excellent therapeutic effects on pruritus with less side effects.
摘要翻译： 治疗瘙痒的外用药物包括阿司匹林。 活动：止痒。 在测试中，施用于昆虫叮咬的2重量％阿司匹林溶液将瘙痒减少85.7％，而对于0.1重量％的地塞米松组合物，其为60.0％。 行动机制：无给予。
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公开(公告)号：EP1249239B1
公开(公告)日：2008-05-21
申请号：EP00981741.2
申请日：2000-12-15
发明人： INAMOTO, Yukiko , KAWATA, Mitsuhiro , KAWABATA, Seiichiro , NAKAYAMA, Daisuke , HISAICHI, Shin-ichi , TOKUDA, Masaaki
CPC分类号： A61K9/0014 , A61K9/06 , A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/616 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/26
摘要： Antipruritic agents for external use containing aspirin, which exerts an excellent therapeutic effect on itching with little side effects, as the active ingredient.
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公开(公告)号：EP2098227B1
公开(公告)日：2013-07-24
申请号：EP07739887.3
申请日：2007-03-27
IPC分类号： A61K31/047 , A61K31/7004 , A61P1/02 , C07H3/02 , A61K8/60 , A61Q11/00
CPC分类号： A61K8/60 , A61K31/047 , A61K31/7004 , A61Q11/00 , C07H3/02
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10.发明公开CYCLOBUTYL PURINE DERIVATIVE, ANGIOGENESIS PROMOTING AGENT, LUMENIZATION PROMOTING AGENT, NEUROCYTE GROWTH PROMOTING AGENT, AND DRUG 有权环戊基嘌呤衍生物，血管生成促进剂，促进促进剂，神经细胞生长促进剂和药物
公开(公告)号：EP2377865A1
公开(公告)日：2011-10-19
申请号：EP09829176.8
申请日：2009-11-27
发明人： TSUKAMOTO, Ikuko , KONISHI, Ryoji , TOKUDA, Masaaki , KUBOTA, Yasuo , KOSAKA, Hiroaki , IGARASHI, Junsuke , MARUYAMA, Tokumi
IPC分类号： C07D473/34 , A61K31/52 , A61P9/00 , A61P9/10 , A61P17/02 , A61P25/00 , A61P25/28 , C07D473/40
CPC分类号： C07D473/18 , C07D473/24 , C07D473/34 , C07D473/40
摘要： Provided is a compound having at least one selected from the group consisting of cell growth promoting activity, angiogenesis promoting activity, lumen formation promoting activity, cell migration promoting activity, and neurocyte growth promoting activity, which is a chemically stable low-molecular-weight substance that has high absorbability and can be supplied stably at a low cost because of its low molecular weight. A cyclobutyl purine derivative, a tautomer or stereoisomer thereof, or a salt, solvate, or hydrate thereof according to the present invention is a cyclobutyl purine derivative represented by the following general formula (1), a tautomer or stereoisomer thereof, or a salt, solvate, or hydrate thereof.
摘要翻译： 本发明提供具有选自由化学稳定的低分子量物质构成的细胞生长促进活性，血管生成促进活性，管腔形成促进活性，细胞迁移促进活性和神经细胞生长促进活性中的至少一种的化合物 具有高吸收性并且由于其低分子量可以以低成本稳定供应。 根据本发明的环丁基嘌呤衍生物，其互变异构体或立体异构体或其盐，溶剂化物或水合物是由以下通式（1）表示的环丁基嘌呤衍生物，其互变异构体或立体异构体或其盐， 溶剂化物或其水合物。
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