专利检索 ap:("G.D. SEARLE & CO.") AND inv:"ABOOD, Norman, A." 第 1 页

1.

发明公开
SYNTHESIS N-PROTECTED AMINO ACIDS, ESPECIALLY N-BOC-L-PROPARGYLGLYCINE BY ZINC-MEDIATED ADDITION OR ORGANIC HALIDES TO GLYCINE CATION EQUIVALENT 失效
标题翻译：的N-GESHÜTZTEN氨基酸，特别是N-BOC-L-炔丙基甘氨酸锌CATALYSIERTE ADDITION有机卤化物甘氨酸阳离子当量的合成

公开(公告)号：EP0755379A1

公开(公告)日：1997-01-29

申请号：EP95916233.0

申请日：1995-04-11

申请人： G.D. SEARLE & CO.

发明人： ABOOD, Norman, A. , NOSAL, Roger, A.

IPC分类号： C07C269 , C07C271 , C12P13 , C12P41 , C12S1 , C12S9

CPC分类号： C07C271/22 , C07C269/06 , C12P13/04 , C12P41/005

摘要： A method is described for synthesis of N-protected amino acids, especially N-Boc-L-propargylglycine, a key intermediate used in the preparation of high-potency, orally-active renin inhibitors. This method involves reaction of an organic halide with a glycine cation equivalent, such as methyl N-Boc-2-acetoxyglycine, in the presence of zinc dust to give Boc-protected amino acid derivatives in high yield. Typically useful organic halides are allylic, benzylic and propargylic halides. Resolution of methyl N-Boc-propargylglycine with alpha-chymotrypsin provides N-Boc-L-propargylglycine in high yield.

2.

发明授权
PLATELET AGGREGATION INHIBITORS CONTAINING C-TERMINAL AMINERGIC SIDE CHAIN AMINO ACID RESIDUES 失效
标题翻译：血小板聚集的抑制剂，WITH胺能侧链的C-末端的氨基酸残基。包含

公开(公告)号：EP0835265B1

公开(公告)日：2002-08-07

申请号：EP96909731.0

申请日：1996-03-22

申请人： G.D. SEARLE & CO.

发明人： ABOOD, Norman, A. , BOVY, Philippe, R. , FLYNN, Daniel, L. , RICO, Joseph, G. , ROGERS, Thomas, E.

IPC分类号： C07K14/75 , C07K5/06 , A61K38/05

CPC分类号： C07K5/021 , A61K38/00 , C07K5/0202 , C07K5/06113

3.

发明公开
PLATELET AGGREGATION INHIBITORS CONTAINING C-TERMINAL AMINERGIC SIDE CHAIN AMINO ACID RESIDUES 失效
标题翻译：血小板聚集的抑制剂，WITH胺能侧链中的C末端氨基酸残基。包含

公开(公告)号：EP0835265A1

公开(公告)日：1998-04-15

申请号：EP96909731.0

申请日：1996-03-22

申请人： G.D. SEARLE & CO.

发明人： ABOOD, Norman, A. , BOVY, Philippe, R. , FLYNN, Daniel, L. , RICO, Joseph, G. , ROGERS, Thomas, E.

IPC分类号： A61K38 , A61P7 , C07K5

CPC分类号： C07K5/021 , A61K38/00 , C07K5/0202 , C07K5/06113

摘要： This invention relates to compounds having formula (I) or pharmaceutically acceptable salts thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions containing such compounds, and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.