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公开(公告)号：EP2766325B1
公开(公告)日：2020-03-18
申请号：EP12781295.6
申请日：2012-10-15
发明人： BHALLA, Rajiv , WILSON, Anthony , KHAN, Imtiaz , BROWN, Jane
IPC分类号： A61K51/04 , C07C303/30 , C07D451/02 , C07C227/16 , C07C67/10 , C07C319/14 , C07B59/00
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公开(公告)号：EP2766325A1
公开(公告)日：2014-08-20
申请号：EP12781295.6
申请日：2012-10-15
发明人： BHALLA, Rajiv , WILSON, Anthony , KHAN, Imtiaz , BROWN, Jane
IPC分类号： C07B59/00 , C07C67/10 , C07C213/08 , C07C227/16 , C07C229/36 , C07C269/06 , C07C271/18 , C07C271/34 , C07C319/14 , C07C323/03 , C07C323/44 , C07C323/58
摘要： The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimized.
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公开(公告)号：EP2766326B1
公开(公告)日：2019-11-27
申请号：EP12781296.4
申请日：2012-10-15
发明人： NAIRNE, Robert, James, Domett , BHALLA, Rajiv , KHAN, Imtiaz , BROWN, Jane , WILSON, Anthony , BLACK, Andrew
IPC分类号： C07C319/20 , C07C319/14 , C07C303/30 , C07C227/16 , C07C67/10 , C07D451/02 , C07B59/00 , B01L3/00 , A61K51/04
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公开(公告)号：EP3036209B1
公开(公告)日：2018-08-01
申请号：EP14758263.9
申请日：2014-08-21
IPC分类号： C07B59/00 , B01J19/24 , C07C303/22 , C07C303/30 , C07C303/44
CPC分类号： C07C303/22 , B01J19/24 , B01J2219/24 , C07B59/001 , C07B2200/05 , C07C303/30 , C07C303/44 , C07C309/73
摘要： [18F]-fluoralkyl tosylates are useful building block for the radiosynthesis of a number of small molecules. A method of purifying [18F]-fluoroalkyl tosylates using an automated radiosynthesis apparatus (e.g. FASTlab module) is described. A method of purifying [18F]-fluoroalky tosylates using a FASTlab module that includes a solid phase extraction (SPE) purification system is described.
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公开(公告)号：EP2382185A1
公开(公告)日：2011-11-02
申请号：EP10702653.6
申请日：2010-01-29
IPC分类号： C07C243/38 , A61K51/04
CPC分类号： A61K51/0406 , A61K51/0402 , A61K51/0455 , C07C241/04 , C07D213/77 , C07F7/2212 , C07C243/32
摘要： The present invention provides a method for the synthesis of radioiodinated compounds which is advantageous over prior art methods. Using a hydrazine or an aminoxy in place of a primary amine for indirect radioiodination facilitates a much quicker reaction thus reducing reaction time and increasing the yield. In addition, where there are primary amines in the molecule to be radioiodinated, such as the N-terminus of a peptide or lysine residues, reaction at the hydrazine or aminoxy is greatly favoured.
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公开(公告)号：EP3036209A1
公开(公告)日：2016-06-29
申请号：EP14758263.9
申请日：2014-08-21
IPC分类号： C07B59/00
CPC分类号： C07C303/22 , B01J19/24 , B01J2219/24 , C07B59/001 , C07B2200/05 , C07C303/30 , C07C303/44 , C07C309/73
摘要： [18F]-fluoralkyl tosylates are useful building block for the radiosynthesis of a number of small molecules. A method of purifying [18F]-fluoroalkyl tosylates using an automated radiosynthesis apparatus (e.g. FASTlab module) is described. A method of purifying [18F]-fluoroalky tosylates using a FASTlab module that includes a solid phase extraction (SPE) purification system is described.
摘要翻译： [18 F] - 甲苯磺酸烷基酯可用于许多小分子的放射合成。 描述了使用自动放射合成装置（例如FASTlab模块）纯化[18 F] - 氟烷基甲苯磺酸酯的方法。 描述了使用包含固相萃取（SPE）纯化系统的FASTlab模块来纯化[18 F] - 氟烷基甲苯磺酸酯的方法。
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