公开(公告)号：EP4282856A1

公开(公告)日：2023-11-29

申请号：EP22899903.3

申请日：2022-07-07

申请人： Zhejiang Nhu Pharmaceutical Co. Ltd. ,  Shangyu Nhu Bio-Chem Co., Ltd. ,  Zhejiang NHU Company Ltd.

发明人： XU, Songhua ,  YAO, Xianghua ,  SONG, Yinjiang ,  HE, Xiaoxiang ,  CHEN, Lihuan ,  LI, Feng ,  PAN, Yinxia ,  ZHAN, Pingping

IPC分类号： C07C303/30 ,  C07C309/14 ,  B01J31/18

摘要： The present disclosure discloses a method for preparing taurine. The method includes: (1) subjecting a sodium hydroxyethyl sulfonate aqueous solution to an ammonolysis reaction with ammonia under the action of an ammonia water complex ion catalyst to obtain a reaction solution containing sodium taurine; and (2) subjecting the reaction solution containing sodium taurine to deamination, dewatering by concentration, acidification and crystallization to obtain the taurine and a mother solution; where the ammonia water complex ion catalyst is obtained by complexation of ammonia and a catalyst precursor, and the catalyst precursor includes one or more metallic elements of chromium, zinc, nickel, cobalt, copper and silver. The method has the advantages of mild process conditions, short reaction time, high yield and a simple catalyst source.

公开(公告)号：EP3677569A1

公开(公告)日：2020-07-08

申请号：EP18851961.5

申请日：2018-08-10

申请人： Sanko Co., Ltd.

发明人： KINISHI, Ryoichi ,  ISHIBASHI, Yoshimi

IPC分类号： C07C309/73 ,  B41M5/333 ,  C07C303/30

摘要： The present invention relates to an N,N'-diurea derivative represented by the following general formula (1) and a method for producing the same. In addition, the present invention relates to a thermosensitive recording material in which a thermosensitive recording layer including a basic dye which is colorless or lightly colored at room temperature and a developer capable of developing color upon contact with the basic dye by heating is provided on a base sheet, wherein the developer is the N,N'-diurea derivative represented by the following general formula (1):

(wherein R2 is an alkyl group, an aralkyl group, or an aryl group; and A1 is a hydrogen atom or an alkyl group).

公开(公告)号：EP1824805B1

公开(公告)日：2020-02-12

申请号：EP05821819.9

申请日：2005-12-09

申请人： Futurechem Co., Ltd. ,  The Asan Foundation

发明人： CHI, Dae Yoon ,  KIM, Dong Wook ,  OH, Seung Jun, 205-501 Yuwon 2ch Ap. ,  RYU, Jin-sook ,  MOON, Dae Hyuk

IPC分类号： C07C17/007 ,  C07C69/76 ,  C07D233/58 ,  C07J1/00 ,  C07C209/02 ,  C07C253/30 ,  C07C303/30 ,  C07D233/91 ,  C07H5/02 ,  C07H19/06 ,  C07C211/63 ,  C07C215/40 ,  C07C255/42 ,  C07C309/73 ,  C07D451/02

公开(公告)号：EP2940007A4

公开(公告)日：2016-01-13

申请号：EP13869779

申请日：2013-12-24

申请人： NARD INSTITUTE LTD ,  UNIV OSAKA

发明人： NAKAO HIDEKAZU ,  HOSHINO JUNICHI ,  OGATA TOKUTARO ,  MIYASHITA NAOKI ,  YAMAMOTO YOSHIKAZU

IPC分类号： C07C309/73 ,  C07B57/00 ,  C07C269/06 ,  C07C271/22 ,  C07C303/30 ,  C07F7/18

CPC分类号： C07C229/36 ,  C07C227/16 ,  C07C271/22 ,  Y02P20/55

摘要： The objective of the present invention is to provide a tyrosine derivative which is useful as a melatonin MT 1 receptor antagonist, and a method for producing a specific tyrosine derivative with high yield by efficiently introducing an iodine atom at the para position of the phenolic hydroxy group in the benzene ring of tyrosine with good regioselectivity. The tyrosine derivative of the present invention is characterized in being represented by the following formula (I) : wherein R 1 is a protective group of the amino group and the like; R 2 is a protective group of the carboxy group and the like; R 3 is a hydrogen atom and the like; R 4 is a halogen atom and the like; A is -(CH 2 ) l -[Z(CH 2 ) m ] n -; X is a leaving group.

摘要翻译： 本发明的目的是提供可用作褪黑激素MT 1受体拮抗剂的酪氨酸衍生物，以及通过在酚羟基的对位有效引入碘原子而以高产率制备特异性酪氨酸衍生物的方法 在酪氨酸苯环中具有良好的区域选择性。 本发明的酪氨酸衍生物的特征在于由下式（I）表示：其中R 1是氨基的保护基等; R 2是羧基等的保护基; R 3为氢原子等; R 4是卤素原子等; A是 - （CH 2）l - [Z（CH 2）m] n - ; X是离职小组。

公开(公告)号：EP2238123B1

公开(公告)日：2011-07-13

申请号：EP08866458.6

申请日：2008-12-17

申请人： Solvay Solexis S.p.A.

发明人： MARCHIONNI, Giuseppe ,  TORTELLI, Vito

IPC分类号： C07D317/42 ,  C07C43/17 ,  C07C303/30 ,  C07C305/26 ,  C08F261/06 ,  C08F214/18

CPC分类号： C07D317/42 ,  C07C41/24 ,  C07C51/58 ,  C07C303/24 ,  C08F214/18 ,  C08F259/08 ,  C07C59/135 ,  C07C305/26 ,  C07C43/126

摘要： The invention pertains to a process for preparing compounds of formula (I-A) or (I-B) here below: by reaction of perfluoroallylfluorosulfate (FAFS) of formula (II): with at least one hypofluorite of formula (II-A) or (II-B): wherein: RF in formulae (I-A) and (II-A) is a monovalent fluorocarbon C1-C20 group, optionally comprising oxygen catenary atoms, optionally comprising functional groups comprising heteroatoms (e.g. -SO2F groups); R'F in formulae (I-B) and (II-B) is a divalent fluorocarbon C-1-C6 group, preferably a group of formula (III): wherein X1 and X2, equal to or different from each other, are independently a fluorine atom or a C1-C3 fluorocarbon group. The FAFS-hypofluohte adducts of formulae (I-A) and (I-B) can be produced with high selectivity so as to access useful intermediates which can further be reacted taking advantage of the un-modified fluorosulfate group chemistry.

公开(公告)号：EP1824805A4

公开(公告)日：2010-01-06

申请号：EP05821819

申请日：2005-12-09

申请人： FUTURECHEM CO LTD ,  ASAN FOUNDATION

发明人： CHI DAE YOON ,  KIM DONG WOOK ,  OH SEUNG JUN ,  RYU JIN-SOOK ,  MOON DAE HYUK

IPC分类号： C07C17/007 ,  C07C69/76 ,  C07C209/02 ,  C07C211/63 ,  C07C215/40 ,  C07C253/30 ,  C07C255/42 ,  C07C303/30 ,  C07C309/73 ,  C07D233/58 ,  C07D233/91 ,  C07D451/02 ,  C07H5/02 ,  C07H19/06 ,  C07J1/00

CPC分类号： C07C209/02 ,  A61K51/1282 ,  B65B3/003 ,  C07B39/00 ,  C07B59/00 ,  C07B59/002 ,  C07B2200/05 ,  C07C213/08 ,  C07C253/30 ,  C07C303/30 ,  C07D213/64 ,  C07D233/91 ,  C07D451/02 ,  C07H5/02 ,  C07H19/06 ,  C07J1/0051 ,  C07C309/73 ,  C07C255/42 ,  C07C211/63 ,  C07C215/40 ,  C07C217/80

摘要： The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound [18F]florbetaben or [18F]AV-45 having and , respectively, by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.

公开(公告)号：EP1236713A4

公开(公告)日：2004-10-13

申请号：EP00974890

申请日：2000-11-09

申请人： AJINOMOTO KK

发明人： KAWAHARA SHIGERU ,  MORI KENICHI ,  NAGASHIMA KAZUTAKA ,  TAKEMOTO TADASHI

IPC分类号： C07C45/41 ,  C07C47/277 ,  C07C51/367 ,  C07C303/30 ,  C07C309/66 ,  C07K5/072 ,  C07K5/075 ,  C07K5/06

CPC分类号： C07C51/367 ,  C07C45/41 ,  C07C47/277 ,  C07C303/30 ,  C07K5/06113 ,  C07C59/64 ,  C07C309/66

摘要： 3-(3-Hydroxy-4-methoxyphenyl)-3-methylbutyric acid can be obtained by substituting the substituent at the 3-position of the benzene ring of a butyric acid derivative which can be easily and efficiently produced by reacting a hydroxyl-protected 2-methoxyphenol, wherein the hydroxyl group of 2-methoxyphenol is protected in the form of a sulfonate, with 3-methylcrotonic acid in the presence of an acid. By further converting the carboxyl group into a formyl group, 3-(3-hydroxy-4-methoxyphenyl)-3-methyl butyl aldehyde can be easily produced. This aldehyde derivative can be easily derived into a compound, which is excellent as a sweetener with a high sweetness, by reductive alkylation with Aspartame.

公开(公告)号：EP1428817A1

公开(公告)日：2004-06-16

申请号：EP02767967.9

申请日：2002-09-18

申请人： ISHIHARA SANGYO KAISHA, LTD.

发明人： NAKAMURA, Yuji, c/o Ishihara Sangyo Kaisha, Ltd. ,  MORITA, Masayuki, c/o Ishihara Sangyo Kaisha, Ltd. ,  YONEDA, Tetsuo, c/o Ishihara Sangyo Kaisha, Ltd. ,  IZAKURA, Kenji, c/o Ishihara Sangyo Kaisha, Ltd.

IPC分类号： C07C231/02 ,  C07C233/76 ,  C07C233/78 ,  C07C233/80 ,  C07C233/87 ,  C07C235/84 ,  C07C269/06 ,  C07C271/44 ,  C07C303/30 ,  C07C303/40 ,  C07C309/66 ,  C07C311/08 ,  C07C329/06 ,  C07D333/22 ,  C07D333/24 ,  C07D333/40 ,  C07D209/42 ,  C07D209/14 ,  C07D215/48 ,  C07D319/20 ,  C07D319/16

CPC分类号： A01N37/20 ,  C07C233/76 ,  C07C307/02 ,  C07C309/65 ,  C07C309/66 ,  C07C311/08 ,  C07C317/32 ,  C07C323/42 ,  C07C329/06 ,  C07D209/14 ,  C07D213/50 ,  C07D213/61 ,  C07D317/46 ,  C07D317/58 ,  C07D319/20 ,  C07D333/22 ,  C07D333/28

摘要： The present invention relates to an acid amid derivative of the formula (I) or a salt thereof:
wherein A is phenyl which may be substituted by X, benzyl which may be substituted by X, naphthyl which may be substituted by X, a heterocyclic group which may be substituted by X, a fused heterocyclic group which may be substituted by X, indanyl (the indanyl may be substituted by halogen, alkyl or alkoxy) or tetrahydronaphthyl (the tetrahydronaphthyl may be substituted by halogen, alkyl or alkoxy), B is alkyl, cycloalkyl, phenyl which may be substituted by Y, a heterocyclic group which may be substituted by Y, or a condensed heterocyclic group which may be substituted by Y, each of R 1 and R 2 is alkyl, cyano or -CO 2 R 14 , or R 1 and R 2 may together form a 3- to 6-membered saturated carbocyclic ring, R 3 is hydrogen, alkyl, alkoxyalkyl, alkylthioalkyl, -COR 15 , -S(O)mR 16 or -S(O)nNR 17 R 18 , which is useful as an active ingredient of pesticides.

摘要翻译： 本发明在或式（I）的酰胺衍生物的盐涉及它们的： worin A是苯基，其可通过X被substituiertem，苄基可以由X被substituiertem，萘基可被X被substituiertem， 这可以通过X，其可以通过X被取代的稠合杂环基被取代的杂环基，茚满基（茚满，可以被卤素，烷基取代的或烷氧基）或四氢（四氢萘基可被卤素，烷基取代或烷氧基） ，B是烷基，环烷基，苯基可以被Y取代，杂环基可以被Y取代，或可以被Y取代的稠合杂环基团，每个R 1和R 2的烷基是，氰基或-CO2R14， 或者R1和R2可一起形成3〜6元饱和碳环，R3是氢，烷基，烷氧基烷基，烷硫基烷基，-COR15，-S（O）MR16或-S（O）nNR17R18，其作为有用 农药的活性成分。

公开(公告)号：EP1123920A1

公开(公告)日：2001-08-16

申请号：EP99947967.8

申请日：1999-10-19

申请人： Agro-Kanesho Co. Ltd.

发明人： USUI, Syuichi, Research Center ,  TAKASUKA, Kiyoshi, Research Center ,  TAKEKITA, Yukinori, Research Center ,  UCHIDA, Junko, Research Center ,  OSAKI, Norio, Research Center

IPC分类号： C07C309/65 ,  C07C323/48 ,  C07C319/20 ,  C07C303/30 ,  A01N41/04 ,  A01N37/30

CPC分类号： C07C309/65 ,  A01N47/02 ,  C07C2601/02

摘要： The present invention relates to a hydrazine oxoacetamide derivative or its salt which exhibits an excellent insecticidal effect even at a low concentration. The hydrazine oxoacetamide derivative has the following Formula (I):
wherein R 1 represents a chlorine atom or a bromine atom, Y represents an oxygen atom or a methylene group, and when Y is an oxygen atom, p is 2 and when Y is a methylene group, p is 0, R 2 represents a trifluoromethyl group, R 3 represents a hydrogen atom or a methyl group, R 4 represents a hydrogen atom or a methyl group, and R 5 represents a methyl group, an ethyl group, an n-propyl group, a cyclopropyl group, an allyl group or a propargyl group.

公开(公告)号：EP0708087B1

公开(公告)日：1999-07-28

申请号：EP95307217.0

申请日：1995-10-11

申请人： ROHM AND HAAS COMPANY

发明人： Spangler, Lori Ann ,  Weaver, Damian Gerard

IPC分类号： C07C303/30 ,  C07C303/32 ,  C07C303/22 ,  C07C309/73 ,  C07C309/68 ,  C07C309/86 ,  C07F9/40

CPC分类号： C07C319/20 ,  C07C303/22 ,  C07C303/30 ,  C07C303/32 ,  C07C319/14 ,  C07F9/4006 ,  C07C309/73 ,  C07C309/75 ,  C07C323/09 ,  C07C309/39 ,  C07C309/42