公开(公告)号：EP1294713A2

公开(公告)日：2003-03-26

申请号：EP01948740.4

申请日：2001-06-26

申请人： GENELABS TECHNOLOGIES, INC.

发明人： ZHANG, Wentao ,  LIEHR, Sebastian, Johannes, R. ,  VELLIGAN, Mark, Douglas ,  DYATKINA, Natalia B. ,  BOTYANSZKI, Janos ,  SHI, Dong-Fang ,  ROBERTS, Christopher, Don ,  KHORLIN, Alexander ,  NELSON, Peter, Harold ,  MUCHOWSKI, Joseph, Martin

IPC分类号： C07D403/14 ,  A61K31/395 ,  A61P31/00 ,  A61P35/00 ,  C07D209/42 ,  C07D207/34 ,  C07D409/14 ,  C07D401/14

CPC分类号： C07D401/14 ,  C07D207/34 ,  C07D209/42 ,  C07D403/14 ,  C07D409/14

摘要： The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): wherein: Z?1 and Z2¿ are independently-NR3-(wherein R3 is hydrogen or alkyl) or -O-; R?1 and R2¿ are independently substituted alkyl, substituted aryl, heteroaryl, or substituted heteroaryl provided that at least one of R?1 and R2¿ is a group that can form a pharmaceutically acceptable acid addition salt; R3 is hydrogen, alkyl or R?3 and R1 or R2¿ together with the atoms to which they are attached form a heterocyclic ring; X2 is aryl, substituted aryl, heteroaryl, substituded heteroaryl, alkenyl, alkynyl, cycloalkyl or heterocyclic; X?1 and X3¿ are independently aryl, substituted aryl, heteroaryl, substituted heteroaryl, or-CHR4, wherein R4 is natural or unnatural amino acid side chain; or a pharmaceutically acceptable acid addition salt thereof.Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.