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1.发明公开NITROGEN-CONTAINING HETEROARYL DERIVATIVES FOR THE TREATMENT OF HCV-INFECTION 审中-公开含氮HETEROARYLDERIVATIVE丙型肝炎病毒感染的治疗
公开(公告)号：EP1631554A2
公开(公告)日：2006-03-08
申请号：EP04776308.1
申请日：2004-06-04
IPC分类号： C07D235/18 , C07D403/12 , A61K31/4184 , A61P31/12
CPC分类号： C07D235/18 , C07D401/14 , C07D403/12
摘要： Disclosed are compounds of formula (I), compositions and methods for treating Flaviviridae family virus infections.
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公开(公告)号：EP1853617A1
公开(公告)日：2007-11-14
申请号：EP06736450.5
申请日：2006-02-28
IPC分类号： C07H19/23 , C07D487/16 , A61K31/55 , A61P31/12 , A61K31/7064
CPC分类号： C07D487/16 , C07H19/00 , C07H19/22 , C07H19/23
摘要： This invention is directed to novel compounds that are useful in the viral infections in mammals, mediated at least in part by a vims in the Flaviviridae family of viruses. In one of its composition aspects, the present invention is directed to compounds of Formula (I).
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公开(公告)号：EP1680436A1
公开(公告)日：2006-07-19
申请号：EP04810014.3
申请日：2004-10-20
IPC分类号： C07H19/14 , A61K31/7064 , A61P31/14
CPC分类号： C07H19/14
摘要： Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.
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公开(公告)号：EP1501850A2
公开(公告)日：2005-02-02
申请号：EP03747674.4
申请日：2003-05-06
发明人： ROBERTS, Christopher, Don , DYATKINA, Natalia, B. , KEICHER, Jesse, D. , LIEHR, Sebastian, Johannes, Reinhard , HANSON, Eric Jason
IPC分类号： C07H19/02
CPC分类号： C07H19/06 , C07H19/052 , C07H19/16 , C07H19/22 , C07H19/23
摘要： Disclosed are compounds, compositions and methods for treating hepatitis C virus infections.
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6.发明公开
公开(公告)号：EP1294713A2
公开(公告)日：2003-03-26
申请号：EP01948740.4
申请日：2001-06-26
发明人： ZHANG, Wentao , LIEHR, Sebastian, Johannes, R. , VELLIGAN, Mark, Douglas , DYATKINA, Natalia B. , BOTYANSZKI, Janos , SHI, Dong-Fang , ROBERTS, Christopher, Don , KHORLIN, Alexander , NELSON, Peter, Harold , MUCHOWSKI, Joseph, Martin
IPC分类号： C07D403/14 , A61K31/395 , A61P31/00 , A61P35/00 , C07D209/42 , C07D207/34 , C07D409/14 , C07D401/14
CPC分类号： C07D401/14 , C07D207/34 , C07D209/42 , C07D403/14 , C07D409/14
摘要： The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): wherein: Z?1 and Z2¿ are independently-NR3-(wherein R3 is hydrogen or alkyl) or -O-; R?1 and R2¿ are independently substituted alkyl, substituted aryl, heteroaryl, or substituted heteroaryl provided that at least one of R?1 and R2¿ is a group that can form a pharmaceutically acceptable acid addition salt; R3 is hydrogen, alkyl or R?3 and R1 or R2¿ together with the atoms to which they are attached form a heterocyclic ring; X2 is aryl, substituted aryl, heteroaryl, substituded heteroaryl, alkenyl, alkynyl, cycloalkyl or heterocyclic; X?1 and X3¿ are independently aryl, substituted aryl, heteroaryl, substituted heteroaryl, or-CHR4, wherein R4 is natural or unnatural amino acid side chain; or a pharmaceutically acceptable acid addition salt thereof.Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.
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7.发明公开
公开(公告)号：EP1976829A2
公开(公告)日：2008-10-08
申请号：EP06845331.5
申请日：2006-12-12
发明人： SCHMITZ, Franz, Ulrich , ROBERTS, Christopher, Don , ABADI, Ali Dehghani Mohammad , GRIFFITH, Ronald, Conrad , LEIVERS, Martin, Robert
IPC分类号： C07D207/16 , C07D209/18 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/40 , A61P31/12
CPC分类号： C07D207/16 , C07D209/18 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Disclosed are compounds having Formula (I) and the compositions and methods relating to these compounds, for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T, Z, R1, Y, and p are disclosed herein.
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公开(公告)号：EP1971597A2
公开(公告)日：2008-09-24
申请号：EP06848636.4
申请日：2006-12-12
发明人： SCHMITZ, Franz, Ulrich , ROBERTS, Christopher, Don , ABADI, Ali, Dehghani Mohammad , GRIFFITH, Ronald, Conrad , LEIVERS, Martin, Robert , SLOBODOV, Irina , RAI, Roopa
IPC分类号： C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04 , A61K31/427 , A61K31/4155 , A61K31/4436
CPC分类号： C07D417/12 , C07D403/12 , C07D413/12 , C07D417/14 , C07D495/04 , C07D513/04
摘要： Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T, Z, R1, Y and p are disclosed herein.
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公开(公告)号：EP1853618A1
公开(公告)日：2007-11-14
申请号：EP06736451.3
申请日：2006-02-28
发明人： KEICHER, Jesse, D. , ROBERTS, Christopher, Don , LIEHR, Sebastian, Johannes, Reinhard , ZHENG, Xiaoling , PRHAVC, Marija , RAJWANSHI, Vivek, Kumar , GRIFFITH, Ronald, Conrad , KIM, Choung, U.
IPC分类号： C07H19/23 , C07D487/16 , A61K31/55 , A61P31/12
CPC分类号： C07D487/16 , C07H19/00 , C07H19/22 , C07H19/23
摘要： Disclosed are tricyclic nucleoside compounds of formula (I), and methods thereof for treating viral infections mediated at least in part by a Flaviviridae family virus.
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公开(公告)号：EP1651631A1
公开(公告)日：2006-05-03
申请号：EP04779723.8
申请日：2004-07-30
发明人： SCHMITZ, Franz, Ulrich , ROBERTS, Christopher, Don , GRIFFITH, Ronald, Conrad , BOTYANSZKI, Janos , GEZGINCI, Mikail, Hakan , GRALAPP, Joshua, Michael , SHI, Dong-Fang , LIEHR, Sebastian, J., R.
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , A61K31/4184 , A61P31/12
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.
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