专利检索 ap:("GENELABS TECHNOLOGIES, INC." OR "GOVERNMENT OF THE UNITED STATES OF AMERICA, as repr. by THE SECR. OF THE DEPT. OF HEALTH AND HUMAN SERVICES AND HIS SUCCESSORS") AND inv:"YARBOUGH, Patrice, O." 第 1 页

1.

发明授权
ENTERICALLY TRANSMITTED NON-A/NON-B HEPATITIS VIRAL AGENT AND CHARACTERISTIC EPITOPES THEREOF 失效
标题翻译：肠溶传输非A /非B型肝炎病毒剂与表位SELBIGEM签名

公开(公告)号：EP0476130B1

公开(公告)日：2008-07-09

申请号：EP91908163.8

申请日：1991-04-05

申请人： GENELABS TECHNOLOGIES, INC. , GOVERNMENT OF THE UNITED STATES OF AMERICA, as repr. by THE SECR. OF THE DEPT. OF HEALTH AND HUMAN SERVICES AND HIS SUCCESSORS

发明人： REYES, Gregory, R. , YARBOUGH, Patrice, O. , BRADLEY, Daniel, W. , KRAWCZYNSKI, Krzysztof, Z. , TAM, Albert , FRY, Kirk, E.

IPC分类号： C12N15/51 , C07K14/08 , G01N33/576 , C12Q1/70 , A61K39/29 , C12N7/02

CPC分类号： C07K16/10 , A61K38/00 , A61K39/00 , C07K14/005 , C07K2319/00 , C07K2319/40 , C07K2319/61 , C12N2770/24222

2.

发明授权
HEPATITIS E VIRUS ANTIGENS AND USES THEREFOR 失效
标题翻译：肝E-病毒抗原及其用途

公开(公告)号：EP0787190B1

公开(公告)日：2004-05-19

申请号：EP95940546.5

申请日：1995-10-23

申请人： GENELABS TECHNOLOGIES, INC.

发明人： FUERST, Thomas, R. , McATEE, C., Patrick , YARBOUGH, Patrice, O. , ZHANG, Yi-Fan

IPC分类号： C12N15/40 , C07K14/08 , G01N33/569 , A61K39/12

CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/10 , C07K2319/00 , C07K2319/40 , C07K2319/61 , C12N2710/14143 , C12N2770/28122 , C12N2770/28123 , C12Q1/707 , G01N33/5767

摘要： Antigens are provided which are derived from the enterically transmitted non-A/non-B viral hepatitis agent, known as hepatitis E virus (HEV). The HEV antigens and in particular, soluble species of the capsid protein encoded by the carboxy terminal region of HEV ORF2, are immunoreactive with sera from individuals infected with HEV. In one embodiment, these antigens may be produced by a baculovirus expression vector and form virus-like particles (VLPs). The antigens are useful as diagnostic reagents in diagnostic methods and kits for determining infection of an individual with HEV. The antigens are also useful in vaccine compositions effective in methods for preventing HEV infection.

3.

发明公开
HEPATITIS E VIRUS ANTIGENS AND USES THEREFOR 失效
标题翻译：肝E-病毒抗原及其用途

公开(公告)号：EP0787190A2

公开(公告)日：1997-08-06

申请号：EP95940546.0

申请日：1995-10-23

申请人： GENELABS TECHNOLOGIES, INC.

发明人： FUERST, Thomas, R. , McATEE, C., Patrick , YARBOUGH, Patrice, O. , ZHANG, Yi-Fan

IPC分类号： G01N33 , A61K38 , A61K39 , A61K48 , A61P31 , C07K14 , C07K16 , C12N15 , C12P21 , C12Q1 , C12R1

CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/10 , C07K2319/00 , C07K2319/40 , C07K2319/61 , C12N2710/14143 , C12N2770/28122 , C12N2770/28123 , C12Q1/707 , G01N33/5767

摘要： Antigens are provided which are derived from the enterically transmitted non-A/non-B viral hepatitis agent, known as hepatitis E virus (HEV). The HEV antigens and in particular, soluble species of the capsid protein encoded by the carboxy terminal region of HEV ORF2, are immunoreactive with sera from individuals infected with HEV. In one embodiment, these antigens may be produced by a baculovirus expression vector and form virus-like particles (VLPs). The antigens are useful as diagnostic reagents in diagnostic methods and kits for determining infection of an individual with HEV. The antigens are also useful in vaccine compositions effective in methods for preventing HEV infection.