公开(公告)号：EP0885294A2

公开(公告)日：1998-12-23

申请号：EP97907730.0

申请日：1997-02-11

申请人： Genentech, Inc. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： BAKER, Joffre ,  CHIEN, Kenneth ,  KING, Kathleen ,  PENNICA, Diane ,  WOOD, William

IPC分类号： A61K38 ,  C12N5

CPC分类号： C12N5/0606 ,  A61K35/34 ,  A61K38/204 ,  C12N2501/115 ,  C12N2501/125 ,  C12N2501/175

摘要： Isolated CT-1, isolated DNA encoding CT-1, and recombinant or synthetic methods of preparing CT-1 are disclosed. CT-1 is shown to bind to and activate the receptor, LIFRβ. These CT-1 molecules are shown to influence hypertrophic activity, neurological activity, and other activities associated with receptor LIFRβ. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, neurological disorders, and other disorders associated with the LIFRβ.

公开(公告)号：EP0830143B1

公开(公告)日：2003-03-05

申请号：EP96913814.8

申请日：1996-04-17

申请人： GENENTECH, INC.

发明人： FERRARA, Napoleone ,  KING, Kathleen ,  LUIS, Elizabeth, A. ,  MATHER, Jennie, P. ,  PAONI, Nicholas, F.

IPC分类号： A61K39/395 ,  A61K38/17 ,  C12N5/12 ,  C07K4/12

CPC分类号： C07K16/244 ,  A61K38/00 ,  A61K39/395 ,  A61K2039/505 ,  A61K38/08 ,  A61K2300/00

摘要： A leukemia inhibitory factor antagonist, alone or in combination with an endothelin antagonist, may be used for treatment of heart failure. The antagonist(s) are administered in a chronic fashion, in therapeutically effective amounts, to achieve this purpose.

公开(公告)号：EP0755446A1

公开(公告)日：1997-01-29

申请号：EP95921220.0

申请日：1995-04-06

申请人： GENENTECH, INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： BAKER, Joffre ,  CHIEN, Kenneth ,  KING, Kathleen ,  PENNICA, Diane ,  WOOD, William

IPC分类号： G01N33 ,  C07K14 ,  C07K16 ,  C12N5 ,  C12N15 ,  C12P21 ,  C12Q1 ,  A61K38 ,  C12R1

CPC分类号： C12Q1/025 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  G01N33/6872 ,  G01N2500/00 ,  Y10S930/14

摘要： Isolated CHF, isolated DNA encoding CHF, and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.

公开(公告)号：EP0755446B1

公开(公告)日：2006-09-13

申请号：EP95921220.0

申请日：1995-04-06

申请人： GENENTECH, INC. ,  The Regents of the University of California

发明人： BAKER, Joffre ,  CHIEN, Kenneth ,  KING, Kathleen ,  PENNICA, Diane ,  WOOD, William

IPC分类号： C12N15/19 ,  C12N15/75 ,  C07K14/52 ,  C07K16/24 ,  C12N1/21 ,  C12N5/16 ,  G01N33/53 ,  C12Q1/68 ,  C12Q1/00

CPC分类号： C12Q1/025 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  G01N33/6872 ,  G01N2500/00 ,  Y10S930/14

摘要： Isolated CHF, isolated DNA encoding CHF, and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.

公开(公告)号：EP0830143A1

公开(公告)日：1998-03-25

申请号：EP96913814.0

申请日：1996-04-17

申请人： GENENTECH, INC.

发明人： FERRARA, Napoleone ,  KING, Kathleen ,  LUIS, Elizabeth, A. ,  MATHER, Jennie, P. ,  PAONI, Nicholas, F.

IPC分类号： C12P21 ,  A61K39 ,  A61K45 ,  A61P9 ,  C07K16 ,  A61K38 ,  C12R1

CPC分类号： C07K16/244 ,  A61K38/00 ,  A61K39/395 ,  A61K2039/505 ,  A61K38/08 ,  A61K2300/00

摘要： A leukemia inhibitory factor antagonist, alone or in combination with an endothelin antagonist, may be used for treatment of heart failure. The antagonist(s) are administered in a chronic fashion, in therapeutically effective amounts, to achieve this purpose.