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公开(公告)号：EP0885294A2
公开(公告)日：1998-12-23
申请号：EP97907730.0
申请日：1997-02-11
发明人： BAKER, Joffre , CHIEN, Kenneth , KING, Kathleen , PENNICA, Diane , WOOD, William
CPC分类号： C12N5/0606 , A61K35/34 , A61K38/204 , C12N2501/115 , C12N2501/125 , C12N2501/175
摘要： Isolated CT-1, isolated DNA encoding CT-1, and recombinant or synthetic methods of preparing CT-1 are disclosed. CT-1 is shown to bind to and activate the receptor, LIFRβ. These CT-1 molecules are shown to influence hypertrophic activity, neurological activity, and other activities associated with receptor LIFRβ. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, neurological disorders, and other disorders associated with the LIFRβ.
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公开(公告)号：EP0755446B1
公开(公告)日：2006-09-13
申请号：EP95921220.0
申请日：1995-04-06
发明人： BAKER, Joffre , CHIEN, Kenneth , KING, Kathleen , PENNICA, Diane , WOOD, William
IPC分类号： C12N15/19 , C12N15/75 , C07K14/52 , C07K16/24 , C12N1/21 , C12N5/16 , G01N33/53 , C12Q1/68 , C12Q1/00
CPC分类号： C12Q1/025 , A01K2217/05 , A61K38/00 , C07K14/52 , G01N33/6872 , G01N2500/00 , Y10S930/14
摘要： Isolated CHF, isolated DNA encoding CHF, and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
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公开(公告)号：EP0755446A1
公开(公告)日：1997-01-29
申请号：EP95921220.0
申请日：1995-04-06
发明人： BAKER, Joffre , CHIEN, Kenneth , KING, Kathleen , PENNICA, Diane , WOOD, William
CPC分类号： C12Q1/025 , A01K2217/05 , A61K38/00 , C07K14/52 , G01N33/6872 , G01N2500/00 , Y10S930/14
摘要： Isolated CHF, isolated DNA encoding CHF, and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
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公开(公告)号：EP1572130A2
公开(公告)日：2005-09-14
申请号：EP03763223.9
申请日：2003-07-08
申请人： GENENTECH, INC.
发明人： CHIU, Henry , CLARK, Hilary , DENNIS, Kathryn , FONG, Sherman , SCHOENFELD, Jill , WOOD, William , WU, Thomas
IPC分类号： A61K7/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4713 , G01N33/564
摘要： The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
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公开(公告)号：EP0848755A1
公开(公告)日：1998-06-24
申请号：EP96931450.0
申请日：1996-08-30
申请人： Genentech, Inc.
发明人： LEE, James , WOOD, William
IPC分类号： G01N33 , A61K31 , A61K38 , A61K48 , A61P9 , A61P17 , C07K14 , C07K16 , C07K19 , C12N5 , C12N15 , C12P21 , C12R1
CPC分类号： C07K16/22 , A61K38/00 , C07K14/52 , C07K14/71 , C07K2319/00 , C07K2319/30
摘要： A human VEGF-related protein (VRP) has been identified and isolated that binds to, and stimulates the phosphorylation of, the receptor tyrosine kinase Flt4. The VRP is postulated to be a third member of the VEGF protein family. Also provided are antibodies that bind to VRP and neutralize a biological activity of VRP, compositions containing the VRP or antibody, methods of use, chimeric polypeptides, and a signal polypeptide for VRP.
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公开(公告)号：EP0848755B2
公开(公告)日：2011-02-09
申请号：EP96931450.9
申请日：1996-08-30
申请人： Genentech, Inc.
发明人： LEE, James , WOOD, William
CPC分类号： C07K16/22 , A61K38/00 , C07K14/52 , C07K14/71 , C07K2319/00 , C07K2319/30
摘要： A human VEGF-related protein (VRP) has been identified and isolated that binds to, and stimulates the phosphorylation of, the receptor tyrosine kinase Flt4. The VRP is postulated to be a third member of the VEGF protein family. Also provided are antibodies that bind to VRP and neutralize a biological activity of VRP, compositions containing the VRP or antibody, methods of use, chimeric polypeptides, and a signal polypeptide for VRP.
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公开(公告)号：EP0848755B9
公开(公告)日：2004-02-04
申请号：EP96931450.9
申请日：1996-08-30
申请人： Genentech, Inc.
发明人： LEE, James , WOOD, William
CPC分类号： C07K16/22 , A61K38/00 , C07K14/52 , C07K14/71 , C07K2319/00 , C07K2319/30
摘要： A human VEGF-related protein (VRP) has been identified and isolated that binds to, and stimulates the phosphorylation of, the receptor tyrosine kinase Flt4. The VRP is postulated to be a third member of the VEGF protein family. Also provided are antibodies that bind to VRP and neutralize a biological activity of VRP, compositions containing the VRP or antibody, methods of use, chimeric polypeptides, and a signal polypeptide for VRP.
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公开(公告)号：EP0848755B1
公开(公告)日：2003-06-11
申请号：EP96931450.9
申请日：1996-08-30
申请人： Genentech, Inc.
发明人： LEE, James , WOOD, William
CPC分类号： C07K16/22 , A61K38/00 , C07K14/52 , C07K14/71 , C07K2319/00 , C07K2319/30
摘要： A human VEGF-related protein (VRP) has been identified and isolated that binds to, and stimulates the phosphorylation of, the receptor tyrosine kinase Flt4. The VRP is postulated to be a third member of the VEGF protein family. Also provided are antibodies that bind to VRP and neutralize a biological activity of VRP, compositions containing the VRP or antibody, methods of use, chimeric polypeptides, and a signal polypeptide for VRP.
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