公开(公告)号：EP0938497B1

公开(公告)日：2007-02-28

申请号：EP97948165.2

申请日：1997-11-05

申请人： GENENTECH, INC.

发明人： BRAISTED, Andrew ,  JUDICE, J., Kevin ,  MCDOWELL, Robert, S. ,  PHELAN, J., Christopher ,  STAROVASNIK, Melissa, A. ,  WELLS, James, A.

IPC分类号： C07K14/16 ,  A61K39/21 ,  C07K16/10

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C12N2740/16122

摘要： Provided are cyclized peptides with a constrained region(s) having an α-helical conformation. Constrained helical peptides having amino acid sequences from HIV gp41 are provided, as is their use in preparing antibodies that prevent viral membrane fusion. Also provided are methods for making such cyclized peptides.

公开(公告)号：EP0938497A1

公开(公告)日：1999-09-01

申请号：EP97948165.0

申请日：1997-11-05

申请人： Genentech, Inc.

发明人： BRAISTED, Andrew ,  JUDICE, J., Kevin ,  MCDOWELL, Robert, S. ,  PHELAN, J., Christopher ,  STAROVASNIK, Melissa, A. ,  WELLS, James, A.

IPC分类号： A61K39 ,  A61P31 ,  C07K7 ,  C07K14 ,  C07K16 ,  A61K38

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C12N2740/16122

摘要： Provided are cyclized peptides with a constrained region(s) having an α-helical conformation. Constrained helical peptides having amino acid sequences from HIV gp41 are provided, as is their use in preparing antibodies that prevent viral membrane fusion. Also provided are methods for making such cyclized peptides.