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1.发明公开
公开(公告)号：EP1187914A1
公开(公告)日：2002-03-20
申请号：EP00941412.9
申请日：2000-06-13
申请人： Genentech, Inc.
IPC分类号： C12N15/10 , C07K1/04 , C07K14/705 , C07K14/71 , G01N33/68
CPC分类号： C07K1/047 , C07K7/06 , C07K7/08 , C07K14/70514 , C07K14/70535 , C07K14/71 , C12N15/1037 , C40B40/02
摘要： The invention is directed to a model system for structure-activity analysis of peptide or protein molecules involved in important biological processes. Provided by the invention are combinatorial peptide libraries comprising disulfide-constrained cyclic peptides with sequences favorable for energy stabilized conformations. A preferred embodiment of the invention is directed to peptides containing β-turn tetrapeptide that form structured β-hairpin scaffold in solution. Methods of selecting and using such peptides are provided herein, which are useful for mimicking in vivo molecular interactions and designing therapeutic agents. Thus, the invention has profound utility for biological studies and drug development.
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公开(公告)号：EP0938497B1
公开(公告)日：2007-02-28
申请号：EP97948165.2
申请日：1997-11-05
申请人： GENENTECH, INC.
发明人： BRAISTED, Andrew , JUDICE, J., Kevin , MCDOWELL, Robert, S. , PHELAN, J., Christopher , STAROVASNIK, Melissa, A. , WELLS, James, A.
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2740/16122
摘要： Provided are cyclized peptides with a constrained region(s) having an α-helical conformation. Constrained helical peptides having amino acid sequences from HIV gp41 are provided, as is their use in preparing antibodies that prevent viral membrane fusion. Also provided are methods for making such cyclized peptides.
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公开(公告)号：EP0938497A1
公开(公告)日：1999-09-01
申请号：EP97948165.0
申请日：1997-11-05
申请人： Genentech, Inc.
发明人： BRAISTED, Andrew , JUDICE, J., Kevin , MCDOWELL, Robert, S. , PHELAN, J., Christopher , STAROVASNIK, Melissa, A. , WELLS, James, A.
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2740/16122
摘要： Provided are cyclized peptides with a constrained region(s) having an α-helical conformation. Constrained helical peptides having amino acid sequences from HIV gp41 are provided, as is their use in preparing antibodies that prevent viral membrane fusion. Also provided are methods for making such cyclized peptides.
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公开(公告)号：EP1812472A1
公开(公告)日：2007-08-01
申请号：EP05818292.4
申请日：2005-10-28
申请人： GENENTECH, INC.
IPC分类号： C07K14/705 , C12N15/10 , C07K14/715
CPC分类号： C07K14/70578 , A61K38/00
摘要： The present invention relates to novel polypeptides and TACI variants that bind APRIL, novel polypeptides and TACI variants that bind BAFF, nucleic acid molecules encoding the polypeptides, host cells comprising the nucleic acid molecules, compositions comprising the polypeptides or nucleic acid molecules, and methods of using the polypeptides and nucleic acid molecules.
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公开(公告)号：EP1629001A2
公开(公告)日：2006-03-01
申请号：EP04776285.1
申请日：2004-06-04
申请人： GENENTECH, INC.
发明人： CHAN, Andrew, Chee-Yuen , GORDON, Nathaniel, C. , KELLEY, Robert, F. , KOEHLER, Michael, F., T. , STAROVASNIK, Melissa, A.
IPC分类号： C07K7/00
CPC分类号： A61K39/3955 , A61K31/57 , A61K31/573 , A61K38/00 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K16/2875 , C07K16/2887 , C07K2317/24 , C07K2317/55 , C07K2317/565 , A61K2300/00
摘要： The present invention relates to polypeptides that block BlyS signaling nucleic acid molecules encoding the polypeptides, and compositions comprising the polypeptides. The present invention also relates to methods for treating an immune-related disease or cancer using the polypeptides and compositions of the invention. The present invention also relates to methods for identifying inhibitors of BlyS signaling .
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6.发明公开A STRUCTURED PEPTIDE SCAFFOLD FOR DISPLAYING TURN LIBRARIES ON PHAGE 审中-公开结构化肽FRAMEWORK FOR可见的发钗环文库在噬菌体上，
公开(公告)号：EP1558644A2
公开(公告)日：2005-08-03
申请号：EP03808995.9
申请日：2003-10-14
申请人： Genentech, Inc.
IPC分类号： C07K16/00
CPC分类号： C40B40/02 , C07K1/047 , C07K7/06 , C07K7/08 , C07K14/70514 , C07K14/70535 , C07K14/71 , C12N15/1037
摘要： The invention is directed to a model system for structure-activity analysis of peptide or protein molecules involved in important biological processes. Provided by the invention are combinatorial peptide libraries comprising disulfide-constrained cyclic peptides with sequences favorable for energy stabilized conformations. One aspect of the invention is directed to cyclic peptide scaffolds that present β-hairpin structure in solution. Methods of selecting and using such peptide scaffolds are provided herein, which are useful for mimicking in vivo molecular interactions and designing therapeutic agents. Thus, the invention has profound utility for biological studies and drug development.
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7.发明授权
公开(公告)号：EP1187914B1
公开(公告)日：2005-05-25
申请号：EP00941412.9
申请日：2000-06-13
申请人： Genentech, Inc.
IPC分类号： C12N15/10 , C07K1/04 , C07K14/705 , C07K14/71 , G01N33/68
CPC分类号： C07K1/047 , C07K7/06 , C07K7/08 , C07K14/70514 , C07K14/70535 , C07K14/71 , C12N15/1037 , C40B40/02
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