公开(公告)号：EP1028744A2

公开(公告)日：2000-08-23

申请号：EP98957711.9

申请日：1998-11-06

申请人： GENETICS INSTITUTE, INC.

发明人： CELESTE, Anthony, J. ,  WOZNEY, John, M. ,  THIES, Scott, R.

IPC分类号： A61K38/18 ,  C12N5/06 ,  C12N5/08

CPC分类号： A61K38/1875 ,  C07K14/51 ,  C12N5/0619 ,  C12N2501/155

摘要： Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction and/or maintenance of bone, cartilage and/or other connective tissue, and/or neuronal tissue.

公开(公告)号：EP0764208A1

公开(公告)日：1997-03-26

申请号：EP95923706.0

申请日：1995-06-05

申请人： GENETICS INSTITUTE, INC.

发明人： ROSEN, Vicki, A. ,  WOZNEY, John, M. ,  CELESTE, Anthony, J. ,  THIES, Scott, R. ,  SONG, Jeffrey, J.

IPC分类号： C12N15 ,  A61K9 ,  A61K38 ,  A61L27 ,  A61P1 ,  A61P19 ,  A61P43 ,  C07K14 ,  C12P21 ,  C12R1

CPC分类号： C07K14/51 ,  A61K38/1875 ,  A61K38/30 ,  A61L27/227 ,  C07K2319/02 ,  Y10S530/84 ,  Y10S930/12 ,  A61K2300/00

摘要： Purified BMP-9 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair, and in hepatic growth and function.