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公开(公告)号：EP0313578B1
公开(公告)日：1996-08-28
申请号：EP87905023.5
申请日：1987-06-30
CPC分类号： C07K14/51 , A61K38/00 , A61L24/043 , A61L27/227 , C08L89/00
摘要： Human and bovine bone inductive factor products and processes. The factors may be produced by recombinant techniques and are useful in the research and treatment of bone and periodontal defects.
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公开(公告)号：EP0592562B1
公开(公告)日：1999-01-07
申请号：EP92914973.0
申请日：1992-06-25
CPC分类号： C07K14/51 , A61K38/00 , C07K2319/02
摘要： Purified BMP-9 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
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公开(公告)号：EP0672138A1
公开(公告)日：1995-09-20
申请号：EP93923220.0
申请日：1993-10-01
CPC分类号： C07K14/755 , A61K38/00 , C07K2319/00 , C07K2319/02
摘要： Provided are porcine factor VIII nucleotide sequences and hybrid sequences encoding human/porcine chimeric factor VIII-type procoagulant proteins. DNAs encoding such chimeric factor VIII-type procoagulant proteins, pharmaceutical compositions containing such chimeric factor VIII-type procoagulant proteins, and methods of treating hemophilia using such chimeric factor VIII-type procoagulant proteins are also provided.
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公开(公告)号：EP0592562A1
公开(公告)日：1994-04-20
申请号：EP92914973.0
申请日：1992-06-25
IPC分类号： A61K38 , A61K47 , A61L27 , A61P1 , A61P17 , A61P19 , A61P25 , A61P43 , C07K14 , C12N5 , C12N15 , C12P21 , C12R1
CPC分类号： C07K14/51 , A61K38/00 , C07K2319/02
摘要： Sont décrits des protéines BMP-9 et des procédés de production de ces protéines. Ces protéines peuvent être utilisées pour le traitement des défauts osseux et cartilagineux ainsi que pour la cicatrisaton des plaies et la réparation des tissus
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公开(公告)号：EP0764208A1
公开(公告)日：1997-03-26
申请号：EP95923706.0
申请日：1995-06-05
发明人： ROSEN, Vicki, A. , WOZNEY, John, M. , CELESTE, Anthony, J. , THIES, Scott, R. , SONG, Jeffrey, J.
CPC分类号： C07K14/51 , A61K38/1875 , A61K38/30 , A61L27/227 , C07K2319/02 , Y10S530/84 , Y10S930/12 , A61K2300/00
摘要： Purified BMP-9 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair, and in hepatic growth and function.
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公开(公告)号：EP0550625A1
公开(公告)日：1993-07-14
申请号：EP91917761.0
申请日：1991-09-26
CPC分类号： C12N15/85 , A61K38/00 , C07K14/51 , C12N2800/108 , C12N2840/20
摘要： L'invention concerne des protéines BMP-5 purifiées ainsi que des procédés pour les produire. Les protéines peuvent être utilisées dans le traitement d'insuffisance et de défauts osseux et/ou cartilagineux ainsi que la cicatrisation de blessures et la réparation de tissus.
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公开(公告)号：EP0429570A1
公开(公告)日：1991-06-05
申请号：EP90905830.0
申请日：1990-03-27
CPC分类号： C07K14/51 , A61K38/00 , C12N15/85 , C12N2840/20
摘要： L'invention concerne des protéines BMP-5, BMP-6 et BMP-7 ainsi que leur procédé de production. On peut utiliser lesdites protéines dans le traitement d'insuffisances osseuses et/ou cartilagineuses, ainsi que pour stimuler la cicatrisation de plaies et la réparation des tissus afférents.
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公开(公告)号：EP1028744A2
公开(公告)日：2000-08-23
申请号：EP98957711.9
申请日：1998-11-06
CPC分类号： A61K38/1875 , C07K14/51 , C12N5/0619 , C12N2501/155
摘要： Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction and/or maintenance of bone, cartilage and/or other connective tissue, and/or neuronal tissue.
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9.发明公开METHODS AND COMPOSITIONS FOR HEALING AND REPAIR OF CONNECTIVE TISSUE ATTACHMENT 无效方法与准备治疗和修复结缔组织附着的
公开(公告)号：EP0831884A1
公开(公告)日：1998-04-01
申请号：EP96916513.0
申请日：1996-05-21
申请人： GENETICS INSTITUTE, INC. , NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY
CPC分类号： C07K14/51 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/414 , A61L2430/10
摘要： Methods and compositions are provided for the treatment of defects and disease involving the functional attachment of connective tissue, such as tendon or ligament, to bone. Preferred methods comprise administering a composition containing a bone morphogenetic protein and a suitable carrier. The method results in the regeneration of functional attachment between the connective tissue and bone, such that minimal fibrous or granulation tissue is formed at the interface between the regenerated bone and connective tissue. The method and composition are useful for augmenting tissue grafts in reconstructive surgery. The method and compositions result in closer apposition of bone to the connective tissue at earlier time points and increased strength of fixation at earlier time points.
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公开(公告)号：EP0429570B1
公开(公告)日：1998-01-14
申请号：EP90905830.7
申请日：1990-03-27
CPC分类号： C07K14/51 , A61K38/00 , C12N15/85 , C12N2840/20
摘要： Purified BMP-5, BMP-6 and BMP-7 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
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