公开(公告)号：EP0888374B1

公开(公告)日：2010-05-19

申请号：EP97905737.9

申请日：1997-01-30

申请人： GILEAD SCIENCES, INC.

发明人： BIESECKER, Gregory ,  GOLD, Larry

IPC分类号： C12N15/11 ,  A61K31/712 ,  C12Q1/68 ,  C07H21/04 ,  C07H21/02 ,  A61K31/7125 ,  A61K31/713

CPC分类号： C12N15/115 ,  A61K38/00 ,  A61K45/06 ,  C12N2310/151 ,  C12N2310/315

摘要： Methods are described for the identification and preparation of high affinity nucleic acid ligands to Complement System Proteins. Methods are described for the identification and preparation of high affinity nucleic acid ligands to Complement System Protein, C1q. Included in the invention are specific RNA ligands to C1q identified by the SELEX method.

公开(公告)号：EP1062226B1

公开(公告)日：2010-06-09

申请号：EP99906778.8

申请日：1999-02-05

申请人： GILEAD SCIENCES, INC.

发明人： BIESECKER, Gregory ,  GOLD, Larry

IPC分类号： C12N15/11 ,  A61K31/713 ,  C07H21/00 ,  A61P25/28 ,  A61P9/10

CPC分类号： C12N15/115 ,  A61K38/00 ,  C07H21/00 ,  C07K14/472 ,  C12N15/1048 ,  C12N2310/151 ,  C12N2310/315 ,  C12N2310/322 ,  C40B40/00

摘要： Methods are described for the identification and preparation of high-affinity Nucleic Acid Ligands to Complement System Proteins. Methods are described for the identification and preparation of high affinity Nucleic Acid Ligands to Complement System Proteins C1q, C3 and C5. Included in the invention are specific RNA ligands to C1q, C3 and C5 identified by the SELEX method.