专利检索 ap:("GILEAD SCIENCES, INC.") AND inv:"DU, Zhimin" 第 1 页

1.

发明授权
AMINOTRIAZINE DERIVATIVES USEFUL AS TANK-BINDING KINASE INHIBITOR COMPOUNDS 有权

公开(公告)号：EP3197884B1

公开(公告)日：2019-03-06

申请号：EP15775054.8

申请日：2015-09-23

申请人： Gilead Sciences, Inc.

发明人： DU, Zhimin , GUERRERO, Juan, A. , KAPLAN, Joshua, A. , KNOX, John, E., Jr. , LO, Jennifer, R. , MITCHELL, Scott, A. , NADUTHAMBI, Devan , PHILLIPS, Barton, W. , VENKATARAMANI, Chandrasekar , WANG, Peiyuan , WATKINS, William, J. , ZHAO, Zhongdong

IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D405/12 , A61K31/53 , A61P35/00 , C07D409/14 , C07D417/14 , C07D487/04 , C07D498/04 , C07D471/08 , C07D471/10 , C07D491/107 , C07D491/113

2.

发明公开
TANK-BINDING KINASE INHIBITOR COMPOUNDS 审中-公开

公开(公告)号：EP3394044A1

公开(公告)日：2018-10-31

申请号：EP16820135.8

申请日：2016-12-15

申请人： Gilead Sciences, Inc.

发明人： DU, Zhimin , DORNAN, David , GUERRERO, Juan A. , KAPLAN, Joshua A. , KNOX, John E. , NADUTHAMBI, Devan , PHILLIPS, Barton W. , STINSON, Susanna Y. , VENKATARAMANI, Chandrasekar , WANG, Peiyuan , WATKINS, William J.

IPC分类号： C07D401/14 , C07D413/14 , C07D401/10 , C07D401/12 , C07D405/12 , C07D239/42 , C07D413/12 , A61K31/4433 , A61P35/00 , A61P37/00

CPC分类号： C07F9/65583 , A61K9/0053 , A61K31/4433 , A61K31/4439 , A61K31/4545 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/675 , A61K45/06 , C07D239/42 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14

摘要： Compounds having the following formula (I) and methods of their use and preparation are disclosed.

3.

发明公开
LPA RECEPTOR ANTAGONISTS AND USES THEREOF 审中-实审

公开(公告)号：EP4337654A1

公开(公告)日：2024-03-20

申请号：EP22727611.0

申请日：2022-05-11

申请人： GILEAD SCIENCES, INC.

发明人： BESTVATER, Brian, P. , DU, Zhimin , FARAND, Julie , VENKATARAMANI, Chandrasekar , YANG, Kin, S. , ZAGORSKA, Anna

IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61P1/16 , A61P9/00 , A61P11/00 , A61P13/12 , A61P29/00 , A61P35/00 , A61K45/00 , A61K31/4439

4.

发明授权
PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS 有权

公开(公告)号：EP3154969B1

公开(公告)日：2019-10-09

申请号：EP15734488.8

申请日：2015-06-10

申请人： GILEAD SCIENCES, INC.

发明人： DU, Zhimin , EVARTS, Jerry , KAPLAN, Joshua , KIM, Musong , NADUTHAMBI, Devan , PATEL, Leena , PERREAULT, Stephane , PHILLIPS, Barton, W. , PHILLIPS, Gary , STEVENS, Kirk, L. , TREIBERG, Jennifer , VAN VELDHUIZEN, Joshua , WATKINS, William, J. , YEUNG, Suet, Chung

IPC分类号： C07D471/04 , C07D403/12 , C07D413/14 , C07D403/14 , C07D239/91 , C07D487/04 , C07D513/04 , A61P35/00 , A61P25/00 , A61K31/517

5.

发明公开
PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS 审中-公开
标题翻译：磷脂酰肌醇3-激酶缝边

公开(公告)号：EP3154969A1

公开(公告)日：2017-04-19

申请号：EP15734488.8

申请日：2015-06-10

申请人： GILEAD SCIENCES, INC.

发明人： DU, Zhimin , EVARTS, Jerry , KAPLAN, Joshua , KIM, Musong , NADUTHAMBI, Devan , PATEL, Leena , PERREAULT, Stephane , PHILLIPS, Barton, W. , PHILLIPS, Gary , STEVENS, Kirk, L. , TREIBERG, Jennifer , VAN VELDHUIZEN, Joshua , WATKINS, William, J. , YEUNG, Suet, Chung

IPC分类号： C07D471/04 , C07D403/12 , C07D413/14 , C07D403/14 , C07D239/91 , C07D487/04 , C07D513/04 , A61P35/00 , A61P25/00 , A61K31/517

CPC分类号： C07D513/04 , C07D239/91 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D473/34 , C07D487/04

摘要： The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, or a mixture thereof, wherein n, m, q, A′, W1, W2, W3, R1, R2, and R3 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (PI3K) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more PI3K isoforms.

摘要翻译： 本申请提供式（J）化合物或其药学上可接受的盐，异构体或其混合物，其中本文描述了n，m，q，A'，W1，W2，W3，R 1，R 2和R 3。这些化合物是磷脂酰肌醇3-激酶（PI3K）活性的抑制剂，可用于治疗由一种或多种PI3K同种型介导的病症。本申请还提供包含式（J）化合物或其药学上可接受的盐，异构体，互变异构体或其混合物的药物组合物，以及使用这些化合物和组合物治疗由一种或多种PI3K同种型介导的病症的方法。

6.

发明授权
ANTIVIRAL COMPOUNDS 有权
标题翻译：抗病毒化合物

公开(公告)号：EP2321319B1

公开(公告)日：2012-03-14

申请号：EP09790816.4

申请日：2009-07-24

申请人： Gilead Sciences, Inc.

发明人： AKTOUDIANAKIS, Evangelos , CELEBI, Azim, Alan , DU, Zhimin , JABRI, Salman, Y. , JIN, Haolun , KIM, Choung, U. , LI, Jiayao , METOBO, Samuel, E. , MISH, Michael, R. , PHILLIPS, Barton, W. , SAUGIER, Joseph, H. , YANG, Zheng-Yu , ZONTE, Catalin, Sebastian

IPC分类号： C07D471/16 , C07D498/16 , A61K31/5383 , A61K31/553 , A61K31/551 , A61K31/4375 , A61P31/18

CPC分类号： C07D498/16 , C07D471/16

摘要： The invention is related to anti-viral compounds of formula (I), compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.