公开(公告)号：EP4234030A2

公开(公告)日：2023-08-30

申请号：EP23162699.5

申请日：2019-07-12

申请人： Gilead Sciences, Inc.

发明人： AKTOUDIANAKIS, Evangelos ,  CHO, Aesop ,  GRAUPE, Michael ,  LAD, Lateshkumar Thakorlal ,  MACHICAO TELLO, Paulo A. ,  MEDLEY, Jonathan William ,  METOBO, Samuel E. ,  NADUTHAMBI, Devan ,  PHILLIPS, Barton W. ,  MONOVICH, Scott Preston ,  WANG, Peiyuan ,  WATKINS, William J. ,  XU, Jie ,  YANG, Kin Shing ,  ZIEBENHAUS, Christopher Allen

IPC分类号： A61P35/00 ,  C07D213/74 ,  C07D241/20 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D471/08 ,  C07D487/10 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497

摘要： Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：EP4282482A3

公开(公告)日：2024-01-17

申请号：EP23197008.8

申请日：2008-03-26

申请人： Gilead Sciences, Inc.

发明人： SOFIA, Michael, Joseph ,  DU, Jinfa ,  WANG, Peiyuan ,  NAGARATHNAM, Dhanapalan

IPC分类号： C07H19/10 ,  A61K31/7072 ,  A61P31/00

摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure:

Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.

公开(公告)号：EP3820572A1

公开(公告)日：2021-05-19

申请号：EP19746317.7

申请日：2019-07-12

申请人： GILEAD SCIENCES, INC.

发明人： AKTOUDIANAKIS, Evangelos ,  CHO, Aesop ,  GRAUPE, Michael ,  LAD, Lateshkumar Thakorlal ,  MACHICAO TELLO, Paulo A. ,  MEDLEY, Jonathan William ,  METOBO, Samuel E. ,  NADUTHAMBI, Devan ,  PHILLIPS, Barton W. ,  MONOVICH, Scott Preston ,  WANG, Peiyuan ,  WATKINS, William J. ,  XU, Jie ,  YANG, Kin Shing ,  ZIEBENHAUS, Christopher Allen

IPC分类号： A61P35/00 ,  C07D213/74 ,  C07D241/20 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D471/08 ,  C07D487/10 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497

公开(公告)号：EP3781556A1

公开(公告)日：2021-02-24

申请号：EP19723257.2

申请日：2019-04-18

申请人： GILEAD SCIENCES, INC.

发明人： AKTOUDIANAKIS, Evangelos ,  CHO, Aesop ,  DU, Zhimin ,  GRAUPE, Michael ,  LAD, Lateshkumar Thakorlal ,  MACHICAO TELLO, Paulo A. ,  MEDLEY, Jonathan William ,  METOBO, Samuel E. ,  MUKHERJEE, Prasenjit Kumar ,  NADUTHAMBI, Devan ,  PARKHILL, Eric Q. ,  PHILLIPS, Barton W. ,  SIMONOVICH, Scott Preston ,  SQUIRES, Neil H. ,  WANG, Peiyuan ,  WATKINS, William J. ,  XU, Jie ,  YANG, Kin Shing ,  ZIEBENHAUS, Christopher Allen

IPC分类号： C07D401/14 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  A61K31/4427 ,  A61P35/00 ,  C07D487/10 ,  C07D491/10

公开(公告)号：EP3612525A1

公开(公告)日：2020-02-26

申请号：EP18723183.2

申请日：2018-04-19

申请人： Gilead Sciences, Inc.

发明人： AKTOUDIANAKIS, Evangelos ,  APPLEBY, Todd ,  CHO, Aesop ,  DU, Zhimin ,  GRAUPE, Michael ,  GUERRERO, Juan A. ,  JABRI, Salman Y. ,  LAD, Lateshkumar Thakorlal ,  MACHICAO TELLO, Paulo A. ,  MEDLEY, Jonathan William ,  METOBO, Samuel E. ,  MUKHERJEE, Prasenjit Kumar ,  NADUTHAMBI, Devan ,  NOTTE, Gregory ,  PARKHILL, Eric Q. ,  PHILLIPS, Barton W. ,  SIMONOVICH, Scott Preston ,  SQUIRES, Neil H. ,  VENKATARAMANI, Chandrasekar ,  WANG, Peiyuan ,  WATKINS, William J. ,  XU, Jie ,  YANG, Kin Shing ,  ZIEBENHAUS, Christopher Allen

IPC分类号： C07D405/14 ,  A61K31/497 ,  C07D403/14 ,  C07D241/18 ,  C07D241/20 ,  C07D487/08 ,  C07D487/10 ,  C07D491/107 ,  C07D519/00 ,  A61P35/00 ,  C07D401/14 ,  C07D401/04 ,  C07D498/04 ,  C07D213/61 ,  C07D213/64

公开(公告)号：EP4282482A2

公开(公告)日：2023-11-29

申请号：EP23197008.8

申请日：2008-03-26

申请人： Gilead Sciences, Inc.

发明人： SOFIA, Michael, Joseph ,  DU, Jinfa ,  WANG, Peiyuan ,  NAGARATHNAM, Dhanapalan

IPC分类号： A61P31/00

摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure:

Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.

公开(公告)号：EP4234030A3

公开(公告)日：2023-10-18

申请号：EP23162699.5

申请日：2019-07-12

申请人： Gilead Sciences, Inc.

发明人： AKTOUDIANAKIS, Evangelos ,  CHO, Aesop ,  GRAUPE, Michael ,  LAD, Lateshkumar Thakorlal ,  MACHICAO TELLO, Paulo A. ,  MEDLEY, Jonathan William ,  METOBO, Samuel E. ,  NADUTHAMBI, Devan ,  PHILLIPS, Barton W. ,  MONOVICH, Scott Preston ,  WANG, Peiyuan ,  WATKINS, William J. ,  XU, Jie ,  YANG, Kin Shing ,  ZIEBENHAUS, Christopher Allen

IPC分类号： A61P35/00 ,  C07D213/74 ,  C07D241/20 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D471/08 ,  C07D487/10 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497

摘要： Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：EP4227302A1

公开(公告)日：2023-08-16

申请号：EP23162059.2

申请日：2019-02-12

申请人： Gilead Sciences, Inc.

发明人： AKTOUDIANAKIS, Evangelos ,  CHO, Aesop ,  DU, Zhimin ,  GRAUPE, Michael ,  LAD, Lateshkumar Thakorlal ,  MACHICAO TELLO, Paulo A. ,  MEDLEY, Jonathan William ,  METOBO, Samuel E ,  MUKHERJEE, Prasenjit Kumar ,  NADUTHAMBI, Devan ,  PARKHILL, Eric Q ,  SIMONOVICH, Scott Preston ,  SQUIRES, Neil H. ,  WANG, Peiyuan ,  WATKINS, William J. ,  XU, Jie ,  YANG, Kin Shing ,  ZIEBENHAUS, Christopher Allen

IPC分类号： C07D405/14 ,  A61K31/497 ,  C07D403/14 ,  C07D241/18 ,  C07D241/20 ,  C07D487/08 ,  C07D487/10 ,  C07D491/107 ,  C07D519/00 ,  A61P35/00

摘要： Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：EP3517536A1

公开(公告)日：2019-07-31

申请号：EP19160625.0

申请日：2015-09-23

申请人： Gilead Sciences, Inc.

发明人： DU, Zhimin ,  GUERRERO, Juan, A. ,  KAPLAN, Joshua, A. ,  KNOX, John E., Jr. ,  LO, Jennifer, R. ,  MITCHELL, Scott, A. ,  NADUTHAMBI, Devan ,  PHILLIPS, Barton, W. ,  VENKATARAMANI, Chandrasekar ,  WANG, Peiyuan ,  WATKINS, William, J. ,  ZHAO, Zhongdong

IPC分类号： C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D405/12 ,  A61K31/53 ,  A61P35/00 ,  C07D409/14 ,  C07D417/14 ,  C07D487/04 ,  C07D498/04 ,  C07D471/08 ,  C07D471/10 ,  C07D491/107 ,  C07D491/113

摘要： Compounds having the following formula (I) and methods of their use and preparation are disclosed:(I).

公开(公告)号：EP3152210A1

公开(公告)日：2017-04-12

申请号：EP15738156.7

申请日：2015-06-02

申请人： Gilead Sciences, Inc.

发明人： DU, Zhimin ,  GUERRERO, Juan, Arnaldo ,  KAPLAN, Joshua, Aaron ,  KNOX, JR., John Edward ,  NADUTHAMBI, Devan ,  PHILLIPS, Barton, W. ,  VENKATARAMANI, Chandrasekar ,  WANG, Peiyuan ,  WATKINS, William, J. ,  ZABLOCKI, Jeff

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D473/00 ,  A61P35/00 ,  A61K31/437 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/52

CPC分类号： C07D471/04 ,  C07D473/00 ,  C07D487/04

摘要： Compounds having the following formula (I) and methods of their use and preparation are disclosed:

摘要翻译： 公开了具有下式（I）的化合物及其使用和制备方法：