公开(公告)号：EP0920410B1

公开(公告)日：2002-03-27

申请号：EP97939508.4

申请日：1997-08-22

申请人： GILEAD SCIENCES, INC.

发明人： KENT, Kenneth, M. ,  KIM, Choung, U. ,  MCGEE, Lawrence, R. ,  MUNGER, John, D. ,  PRISBE, Ernest, J. ,  POSTICH, Michael, J. ,  ROHLOFF, John, C. ,  KELLY, Daphne, E. ,  WILLIAMS, Matthew, A. ,  ZHANG, Lijun

IPC分类号： C07C227/08 ,  C07C247/14 ,  C07D317/46 ,  C07D203/26 ,  C07D303/40 ,  C07F7/18 ,  C07C227/16

CPC分类号： C07D203/26 ,  C07C227/08 ,  C07C2601/16 ,  C07D303/40 ,  C07D317/46 ,  Y02P20/55

摘要： The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates such as those having formulas (I)-(IV), such as those having formulas (I)-(IV), useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

公开(公告)号：EP0920410A1

公开(公告)日：1999-06-09

申请号：EP97939508.0

申请日：1997-08-22

申请人： GILEAD SCIENCES, INC.

发明人： KENT, Kenneth, M. ,  KIM, Choung, U. ,  MCGEE, Lawrence, R. ,  MUNGER, John, D. ,  PRISBE, Ernest, J. ,  POSTICH, Michael, J. ,  ROHLOFF, John, C. ,  KELLY, Daphne, E. ,  WILLIAMS, Matthew, A. ,  ZHANG, Lijun

IPC分类号： C07D317 ,  C07B53 ,  C07C67 ,  C07C69 ,  C07C227 ,  C07C229 ,  C07C231 ,  C07C233 ,  C07C247 ,  C07C309 ,  C07C317 ,  C07D203 ,  C07D303

CPC分类号： C07D203/26 ,  C07C227/08 ,  C07C2601/16 ,  C07D303/40 ,  C07D317/46 ,  Y02P20/55

摘要： The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates such as those having formulas (I)-(IV), such as those having formulas (I)-(IV), useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

摘要翻译： 本发明提供了新的合成方法和组合物。 特别地，制备中间体的新方法如具有式（I） - （IV）的那些，例如具有式（I） - （IV）的那些，可用于神经氨酸酶抑制剂的合成和用作中间体的组合物本身有用的新方法 提供神经氨酸酶抑制剂的合成。