专利检索 ap:("GILEAD SCIENCES, INC.") AND inv:"RINGQUIST, Steven" 第 1 页

1.

发明授权
HIGH-AFFINITY OLIGONUCLEOTIDE LIGANDS TO PDGF 失效
标题翻译：寡核苷酸配体与PDGF高亲和力

公开(公告)号：EP0828849B1

公开(公告)日：2006-10-25

申请号：EP96920573.1

申请日：1996-05-30

申请人： GILEAD SCIENCES, INC.

发明人： TOOTHMAN, Penelope, J. , GOLD, Larry , JANJIC, Nebojsa , RINGQUIST, Steven , PAGRATIS, Nikos

IPC分类号： C12P19/34 , C12Q1/68

CPC分类号： C12N15/115 , B82Y5/00 , C07K14/475 , C07K14/49 , C07K14/495 , C07K14/50 , C12N15/111 , C12N2320/13 , G01N2333/96433

摘要： Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGFβ, PDGF and hKGF. Included in the invention are specific RNA and ssDNA ligands to TGFβ1 and PDGF identified by the SELEX method. Also included in the invention are specific RNA ligands to hKGF identified by the SELEX method. Further included are RNA ligands that inhibit the interaction of TGFβ1 and hKGF with their receptors and DNA ligands that inhibit the interaction of PDGF with its receptor.