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公开(公告)号：EP1363925B8
公开(公告)日：2007-04-25
申请号：EP01271380.6
申请日：2001-12-20
发明人： ANDREOTTI, Daniele, GlaxoSmithKline SpA , ARISTA, Luca, GlaxoSmithKline SpA , BIONDI, Stefano, GlaxoSmithKline SpA , CARDULLO, Francesca, GlaxoSmithKline SpA , DAMIANI, Frederica, GlaxoSmithKline SpA , LOCIURO, Sergio, GlaxoSmithKline SpA , MARCHIORO, Carla, GlaxoSmithKline SpA , MERLO, Giancarlo, GlaxoSmithKline SpA , MINGARDI, Anna, GlaxoSmithKline SpA , NICCOLAI, Daniela, GlaxoSmithKline SpA , PAIO, Alfredo, GlaxoSmithKline SpA , PIGA, Elisabetta, GlaxoSmithKline SpA , POZZAN, Alfonso, GlaxoSmithKline SpA , SERI, Catia, GlaxoSmithKline SpA , TARSI, Luca, GlaxoSmithKline SpA , TERRENI, Silvia, GlaxoSmithKline SpA , TIBASCO, Jessica, GlaxoSmithKline SpA , CIRACO, Manuela, c/o BPB Italia S.p.A.
CPC分类号： C07H17/08 , A61K9/0019 , A61K9/2018 , Y02P20/55
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2.发明公开COMPOUNDS HAVING AFFINITY FOR THE DOPAMINE D3 RECEPTOR AND USES THEREOF IN MEDICINE 审中-公开连接要AFFINITY多巴胺D3受体及其医学应用
公开(公告)号：EP1773844A1
公开(公告)日：2007-04-18
申请号：EP05760843.2
申请日：2005-06-29
申请人： GLAXO GROUP LIMITED
发明人： BONANOMI, Giorgio, GlaxoSmithKline SpA , CARDULLO, Francesca, GlaxoSmithKline SpA , DAMIANI, Federica, GlaxoSmithKline SpA , GENTILE, Gabriella, GlaxoSmithKline SpA , HAMPRECHT, Dieter, GlaxoSmithKline SpA , MICHELI, Fabrizio, GlaxoSmithKline SpA , TARSI, Luca, GlaxoSmithKline SpA
IPC分类号： C07D498/04 , C07D513/04 , A61K31/55 , A61P25/18 , A61P25/30 , C07D263/00 , C07D223/00 , C07D277/00
CPC分类号： C07D513/04
摘要： Compounds of formula (I) or a salt thereof are disclosed, wherein A, m R1, R2, R3, q, W1, W2, R4 and R5 are as defined in the description. Processes for preparation and uses of the compounds in medicine, for example for the treatment of schizophrenia or drug dependency, are also disclosed.
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3.发明授权
公开(公告)号：EP1848695B1
公开(公告)日：2011-07-27
申请号：EP06706948.4
申请日：2006-02-13
申请人： GLAXO GROUP LIMITED
发明人： ANDREOTTI, Daniele, GlaxoSmithKline SpA , ARISTA, Luca, GlaxoSmithKline SpA , CARDULLO, Francesca, GlaxoSmithKline SpA , SPADA, Simone, GlaxoSmithKline SpA , THEWLIS, Kevin, Michael, GlaxoSmithKline , WARD, Simon, Edward, GlaxoSmithKline
IPC分类号： C07D213/61 , C07D213/42 , C07D317/58 , C07D333/20 , C07D213/65 , C07D277/64 , A61K31/4418 , A61K31/36 , A61K31/381 , A61K31/426 , A61P25/18
CPC分类号： C07D277/64 , C07D213/42 , C07D213/61 , C07D213/65 , C07D317/58 , C07D333/20
摘要： This invention relates to potentiation of the glutamate receptor by novel compounds of formula (I): The invention also relates to the use of the derivatives in treating diseases and conditions mediated by potentiation of the glutamate receptor, compositions containing the derivatives and processes for their preparation.
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4.发明公开
公开(公告)号：EP1848695A1
公开(公告)日：2007-10-31
申请号：EP06706948.4
申请日：2006-02-13
申请人： GLAXO GROUP LIMITED
发明人： ANDREOTTI, Daniele, GlaxoSmithKline SpA , ARISTA, Luca, GlaxoSmithKline SpA , CARDULLO, Francesca, GlaxoSmithKline SpA , SPADA, Simone, GlaxoSmithKline SpA , THEWLIS, Kevin, Michael, GlaxoSmithKline , WARD, Simon, Edward, GlaxoSmithKline
IPC分类号： C07D213/61 , C07D213/42 , C07D317/58 , C07D333/20 , C07D213/65 , C07D277/64 , A61K31/4418 , A61K31/36 , A61K31/381 , A61K31/426 , A61P25/18
CPC分类号： C07D277/64 , C07D213/42 , C07D213/61 , C07D213/65 , C07D317/58 , C07D333/20
摘要： This invention relates to potentiation of the glutamate receptor by novel compounds of formula (I): The invention also relates to the use of the derivatives in treating diseases and conditions mediated by potentiation of the glutamate receptor, compositions containing the derivatives and processes for their preparation.
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公开(公告)号：EP1363925B1
公开(公告)日：2006-11-15
申请号：EP01271380.6
申请日：2001-12-20
申请人： GLAXO GROUP LIMITED , PLIVA D.D.
发明人： ANDREOTTI, Daniele, GlaxoSmithKline SpA , ARISTA, Luca, GlaxoSmithKline SpA , BIONDI, Stefano, GlaxoSmithKline SpA , CARDULLO, Francesca, GlaxoSmithKline SpA , DAMIANI, Frederica, GlaxoSmithKline SpA , LOCIURO, Sergio, GlaxoSmithKline SpA , MARCHIORO, Carla, GlaxoSmithKline SpA , MERLO, Giancarlo, GlaxoSmithKline SpA , MINGARDI, Anna, GlaxoSmithKline SpA , NICCOLAI, Daniela, GlaxoSmithKline SpA , PAIO, Alfredo, GlaxoSmithKline SpA , PIGA, Elisabetta, GlaxoSmithKline SpA , POZZAN, Alfonso, GlaxoSmithKline SpA , SERI, Catia, GlaxoSmithKline SpA , TARSI, Luca, GlaxoSmithKline SpA , TERRENI, Silvia, GlaxoSmithKline SpA , TIBASCO, Jessica, GlaxoSmithKline SpA , CIRACO, Manuela, c/o BPB Italia S.p.A.
CPC分类号： C07H17/08 , A61K9/0019 , A61K9/2018 , Y02P20/55
摘要： The present invention relates to 11,12 gamma lactone ketolides of formula (I) wherein R, R , R , R are as defined herein and pharmaceutically acceptable salts and solvates thereof, to process for their preparation and their use in therapy or prophylaxis of systemic or topical bacterial infections in a human or animal body.
摘要翻译： 本发明涉及其中R，R 1，R 2，R 3如本文所定义的式（I）的11,12-内酯酮内酯及其药学上可接受的盐和溶剂合物，以制备其制备方法 以及它们在治疗或预防人或动物体内的全身或局部细菌感染中的用途。
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6.发明公开CYCLIC AMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开衍生物环胺，方法用于产生和含YOU的药物组合物
公开(公告)号：EP1622871A1
公开(公告)日：2006-02-08
申请号：EP04731635.1
申请日：2004-05-07
申请人： GLAXO GROUP LIMITED
发明人： ALVARO, Giuseppe, GlaxoSmithKline SpA , ARISTA, Luca, GlaxoSmithKline SpA , CARDULLO, Francesca, GlaxoSmithKline SpA , D'ADAMO, Lucilla, GlaxoSmithKline SpA , FERIANI, Aldo, GlaxoSmithKline SpA , GIOVANNINI, Riccardo, GlaxoSmithKline SpA , SERI, Catia, GlaxoSmithKline SpA
IPC分类号： C07D211/34 , C07D405/12 , C07D405/04 , A61K31/445 , A61K31/4465 , A61P25/22 , A61P25/00
CPC分类号： C07D405/04 , C07D211/34 , C07D405/12
摘要： A compound of formula (I) wherein R represents a radical selected from i) ii) iii) iv) where the substituents R1, R2, R3, R4, R4, R7 and the indices m, n and p are as defined in the description; or pharmaceutically acceptable salts and solvates thereof; processes for their preparation to pharmaceutical compositions containing them and their use in the treatment of conditions mediated by tachykinins and/or by selective inhibition of serotonin reuptake transporter protein.
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