-
1.发明公开SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION 审中-公开取代HETEROARYLALDEHYDVERBINDUNGEN和方法用于组织氧合的增加
公开(公告)号：EP2797597A4
公开(公告)日：2015-06-24
申请号：EP12862096
申请日：2012-12-28
发明人： METCALF BRIAN , CHUANG CHIHYUAN , WARRINGTON JEFFREY , PAULVANNAN KUMAR , JACOBSON MATTHEW P , HUA LAN , MORGAN BRADLEY
IPC分类号： A61K31/44 , C07D401/12 , C07D401/14 , C07D403/14 , C07D471/14 , C07D487/04
CPC分类号： C07D401/12 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/80 , C07D401/14 , C07D405/14 , C07D413/12 , C07D471/04 , C07D487/04
摘要： Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
摘要翻译： 本发明提供substituiertem杂芳基醛和它们的衍生物也充当的血红蛋白，方法和中间体及其制备变构调节剂，药物组合物，其包括调制器，和方法及其在治疗病症使用由血红蛋白调解和病症也会因增加组织氧合受益。
-
2.发明公开
公开(公告)号：EP2797416A4
公开(公告)日：2015-12-23
申请号：EP12862525
申请日：2012-12-28
发明人： METCALF BRIAN , CHUANG CHIHYUAN , WARRINGTON JEFFREY , PAULVANNAN KUMAR , JACOBSON MATTHEW P , HUA LAN , MORGAN BRADLEY
IPC分类号： A01N35/00 , A61K31/11 , C07C65/21 , C07C69/76 , C07D211/62 , C07D213/30 , C07D213/80 , C07D215/14 , C07D231/56 , C07D257/04 , C07D401/04 , C07D471/04 , C07D487/04
CPC分类号： A61K31/4985 , A61K31/192 , A61K31/235 , A61K31/41 , A61K31/416 , A61K31/437 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/47 , C07C65/30 , C07C69/76 , C07D211/62 , C07D213/30 , C07D213/80 , C07D215/14 , C07D231/56 , C07D257/04 , C07D401/04 , C07D471/04 , C07D487/04
摘要： Provided are substituted benzaldehydes and derivatives thereof of formula (I) that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
摘要翻译： 本发明提供substituiertem苯甲醛及其式（Ⅰ）所做动作的血红蛋白，方法和中间体其制备方法，药物组合物作为变构调节剂，其包括调制器，以及用于它们在治疗病症的使用方法的衍生物由血红蛋白调解和病症也将受益于 增加组织供氧。
-
搜索结果
2 条记录 (耗时 0.01 秒)
