公开(公告)号：EP1123271A4

公开(公告)日：2004-02-11

申请号：EP00957679

申请日：2000-08-23

申请人： GOLDSCHMIDT CHEMICAL COMPANY

发明人： STEIGER PHILIP HOWARD ,  TONEY CHRISTOPHER JOSEPH

IPC分类号： A61K8/30 ,  A01N25/04 ,  A01N25/30 ,  A61K8/00 ,  A61K8/31 ,  A61K8/34 ,  A61K8/37 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K8/44 ,  A61K8/46 ,  A61K8/89 ,  A61K8/891 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/10 ,  C07B43/00 ,  C07B61/00 ,  C07C213/02 ,  C07C213/08 ,  C07C215/08 ,  C07C215/40 ,  C07C217/08 ,  C07C221/00 ,  C07C225/00 ,  C10M133/06 ,  C10N30/12 ,  C11D1/46 ,  C11D1/62 ,  D06M13/328 ,  D06M13/463 ,  C07C223/00 ,  C07C229/00

CPC分类号： C07C215/40 ,  A61K8/44 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/00 ,  C07C215/08

摘要： A process for making a tertiary amine ester of formula (I), the process comprising: (a) reacting a ketone or an aldehyde having formula (III) with a glycol to form a ketal or an acetal; (b) reacting the ketal or the acetal with acrylonitrile to form an ether nitrile; (c) reducing the ether nitril to a tertiary amine ketal or a tertiary amine acetal; (d) hydrolyzing the tertiary amine ketal or the tertiary amine acetal to a tertiary amine diol; and (e) esterifying the tertiary amine diol to the tertiary amine ester of formula (I), wherein R?1 and R2¿ are each independently a hydrogen atom or a linear, branched, or cyclic alkyl, alkylene, alkaryl, or aryl-containing group containing 1 to 18 carbon atoms; and each R3 are each independently of one another fatty acid radicals having 6-22 carbon atoms. The process may optionally include the further step of: (f) protonating or quaternizing the tertiary amine ester of formula (I) to a protonated or quaternary amine ester of formula (II) wherein A- is an inorganic or organic anion.