公开(公告)号：EP1678147A1

公开(公告)日：2006-07-12

申请号：EP04786953.2

申请日：2004-09-15

申请人： GPC Biotech AG

发明人： CHOIDAS, Axel ,  BACKES, Alexander ,  COTTEN, Matt ,  ENGKVIST, Ola ,  FELBER, Beatrice ,  FREISLEBEN, Achim ,  GODL, Klaus ,  GREFF, Zoltán ,  HABENBERGER, Peter ,  HAFENBRADL, Doris ,  HARTUNG, Christian ,  HERGET, Thomas ,  HOPPE, Edmund ,  KLEBL, Bert ,  MISSIO, Andrea ,  MÜLLER, Gerhard ,  SCHWAB, Wilfried ,  ZECH, Birgit ,  BRAVO, Jose ,  HARRIS, John ,  LE, Joelle ,  MACRITCHIE, Jackie ,  SAVIC, Vladimir ,  SHERBORNE, Brad ,  SIMPSON, Don

IPC分类号： C07D239/42 ,  C07D401/12 ,  C07D239/48 ,  C07D403/12 ,  C07D401/04 ,  C07D409/12 ,  C07D417/12 ,  C07D405/12 ,  C07D409/14 ,  C07D413/12 ,  C07D409/04 ,  A61K31/505

CPC分类号： C04B35/632 ,  C07D239/42 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furhtermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.

公开(公告)号：EP1789393A2

公开(公告)日：2007-05-30

申请号：EP05775196.8

申请日：2005-08-01

申请人： GPC Biotech AG

发明人： EICKHOFF, Jan, Eike ,  HAFENBRADL, Doris ,  SCHWAB, Wilfried ,  COTTON, Matthew ,  KLEBL, Bert, Matthias ,  ZECH, Birgit ,  MÜLLER, Stefan ,  HARRIS, John ,  SAVIC, Vladimir ,  MACRITCHIE, Jackie ,  SHERBORNE, Brad ,  LE, Joelle

IPC分类号： C07D213/74

CPC分类号： C07D213/74

摘要： Described are pyridinylamines and pharmaceutically acceptable salts thereof, the use of these pyridinylamines for the prophylaxis and/or treatment of various diseases such as infectious diseases, including opportunistic infections, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as pharmaceutical compositions containing at least one pyridinylamine and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the pyridinylamines are disclosed.

摘要翻译： 描述了吡啶基胺及其药学上可接受的盐，这些吡啶基胺用于预防和/或治疗各种疾病，例如感染性疾病，包括机会性感染，朊病毒病，免疫性疾病，自身免疫性疾病，双相性和临床疾病，心血管疾病， 细胞增殖性疾病，糖尿病，炎症，移植排斥，勃起功能障碍，神经变性疾病和中风，以及含有至少一种吡啶基胺和/或其药学上可接受的盐的药物组合物。 此外，公开了合成吡啶基胺的反应程序。