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    Pharmaceutical compositions containing benzoyl urea derivatives
    3.
    发明公开
    Pharmaceutical compositions containing benzoyl urea derivatives 失效
    Benzoylharnstoff-Derivate enthaltende Arzneimittel。

    公开(公告)号：EP0264904A2

    公开(公告)日：1988-04-27

    申请号：EP87115332.6

    申请日：1987-10-20

    申请人： ISHIHARA SANGYO KAISHA, LTD. ,  GREEN CROSS CORPORATION

    发明人： Kondo, Nobuo ,  Kikuchi, Masahiro ,  Nakajima, Tsunetaka ,  Watanabe, Masahiro ,  Yokoyama, Kazumasa ,  Haga, Takahiro ,  Yamada, Nobutoshi ,  Sugi, Hideo ,  Koyanagi, Toru 3F-410, 151-30, Ninomaru-cho

    IPC分类号： A61K9/14 ,  A61K47/00 ,  A61K31/44 ,  A61K31/50 ,  A61K31/505

    CPC分类号： A61K31/505 ,  A61K9/145 ,  A61K9/146 ,  A61K9/19 ,  A61K31/44 ,  A61K31/50 ,  A61K47/14 ,  A61K47/26 ,  Y10S514/961 ,  Y10S514/964

    摘要： A pharmaceutical composition comprising a benzoyl urea compound (A) selected from the group consisting of a benzoyl urea compound (I) having the formula:
    wherein X is a halogen atom, a nitro group or a trifluoromethyl group, provided that when Y is a nitro group, X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z₁ is a halogen atom or a trifluoromethyl group, Z₂ is a hydrogen atom or a halogen atom, and A is a =CH- group or a nitrogen atom, and a benzoyl urea compound (II) having the formula:
    wherein each of X₁ and X₂ is a hydrogen atom, a halogen atom or a nitro group, provided that when Y is a nitro group, X₁ is a hydrogen atom, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, and Z is a hydrogen atom, a halogen atom or a trifluoromethyl group, as an active ingredient; a nonionic surfactant as a dispersant; and at least one member selected from the group consisting of a saccharide, a saccharide alcohol, silicic anhydride and a nonionic surfactant, as a disintegrator.

    摘要翻译： 一种药物组合物，其包含选自具有下式的苯甲酰脲化合物（I）的苯甲酰脲化合物（A），其中X是卤素原子，硝基或三氟甲基，条件是当Y 是硝基，X是卤原子或硝基，Y是氢原子，卤素原子，硝基或三氟甲基，Z1是卤素原子或三氟甲基，Z2是氢原子或 卤素原子，A为= CH-基或氮原子，和具有下式的苯甲酰脲化合物（II）：其中X1和X2分别为氢原子，卤素原子或硝基， 条件是当Y为硝基时，X 1为氢原子，Y为氢原子，卤原子，硝基或三氟甲基，Z为氢原子，卤素原子或三氟甲基，作为 有效成分; 作为分散剂的非离子表面活性剂; 和选自糖，糖醇，硅酸酐和非离子表面活性剂的至少一种作为崩解剂。

    Fibronectin preparations
    6.
    发明公开
    Fibronectin preparations 失效
    纤连蛋白制剂

    公开(公告)号：EP0179477A2

    公开(公告)日：1986-04-30

    申请号：EP85113535.0

    申请日：1985-10-24

    申请人： GREEN CROSS CORPORATION

    发明人： Hirao, Yutaka ,  Ohmura, Takao ,  Takechi, Kazuo ,  Nakajima, Tsunetaka ,  Nishida, Masayuki

    IPC分类号： A61K37/04

    CPC分类号： A61K47/42 ,  A61K9/0048 ,  A61K38/39 ,  A61K47/10 ,  A61K47/26

    摘要： A fibronectin preparation in the form of an aqueous solution at least upon use is disclosed. The preparation contains at least one member selected from the group consisting of disaccharides. albumin and nonionic surface active agents as a stabilizer. The preparation has improved water-solubility when in use and high stability in an aqueous solution.

    摘要翻译： 公开了至少在使用时以水溶液形式的纤连蛋白制剂。 该制剂含有至少一种选自二糖的成员。 白蛋白和非离子表面活性剂作为稳定剂。 该制剂在使用时具有改善的水溶性和在水溶液中的高稳定性。