公开(公告)号：EP0759029B1

公开(公告)日：1999-07-07

申请号：EP95916503.6

申请日：1995-04-26

申请人： GROPEP PTY. LTD.

发明人： BELFORD, David Andrew ,  ROGERS, Mary-Louise ,  FRANCIS, Geoffrey Leonard ,  REGESTER, Geoffrey Owen ,  SMITHERS, Geoffrey Welsford ,  BALLARD, Francis John

IPC分类号： C07K1/18 ,  C07K1/34 ,  C07K1/36 ,  C12N5/02 ,  A61K38/18 ,  A23J1/20 ,  A23C9/00 ,  A23C21/10

CPC分类号： A23J1/205 ,  A23V2002/00 ,  A61K38/00 ,  C07K14/475 ,  C12N5/0018 ,  C12N2500/84 ,  A23V2250/55 ,  A23V2300/30 ,  A23V2300/34

摘要： The invention provides a process for preparing a plurality of modified milk growth factors which process includes: providing a milk product extract including a plurality of milk growth factors having basic to approximately neutral isoelectric points and a source of acid; subjecting the milk product extract to transient acidification utilising the acid source; and isolating a plurality of modified milk growth factors from the transiently acidified milk product extract. Also provided are growth promoting compositions, cell culture compositions, and pharmaceutical or veterinary compositions for the treatment of surface wounds, gastrointestinal injuries, diseases or ulcers, each including a plurality of modified milk growth factors having isoelectric points above approximately 6.0 and molecular weights in the range of approximately 5000 to 30.000, the milk growth factors being modified by transient acidification.

公开(公告)号：EP0759029A1

公开(公告)日：1997-02-26

申请号：EP95916503.0

申请日：1995-04-26

申请人： GROPEP PTY. LTD.

发明人： BELFORD, David Andrew ,  ROGERS, Mary-Louise ,  FRANCIS, Geoffrey Leonard ,  REGESTER, Geoffrey Owen ,  SMITHERS, Geoffrey Welsford ,  BALLARD, Francis John

IPC分类号： A23J1 ,  A61K35 ,  A61K38 ,  A61P1 ,  C07K1 ,  C07K14 ,  C12N5

CPC分类号： A23J1/205 ,  A23V2002/00 ,  A61K38/00 ,  C07K14/475 ,  C12N5/0018 ,  C12N2500/84 ,  A23V2250/55 ,  A23V2300/30 ,  A23V2300/34

摘要： The invention provides a process for preparing a plurality of modified milk growth factors which process includes: providing a milk product extract including a plurality of milk growth factors having basic to approximately neutral isoelectric points and a source of acid; subjecting the milk product extract to transient acidification utilising the acid source; and isolating a plurality of modified milk growth factors from the transiently acidified milk product extract. Also provided are growth promoting compositions, cell culture compositions, and pharmaceutical or veterinary compositions for the treatment of surface wounds, gastrointestinal injuries, diseases or ulcers, each including a plurality of modified milk growth factors having isoelectric points above approximately 6.0 and molecular weights in the range of approximately 5000 to 30.000, the milk growth factors being modified by transient acidification.

摘要翻译： 本发明提供了一种制备多种改性乳生长因子的方法，该方法包括：提供一种乳制品提取物，该乳制品提取物包括多种具有碱性至中性等电点的乳生长因子和酸源; 利用酸源使奶制品提取物瞬时酸化; 并从瞬时酸化乳制品提取物中分离出多种改良乳生长因子。 还提供了用于治疗表面伤口，胃肠损伤，疾病或溃疡的生长促进组合物，细胞培养组合物和药物组合物或兽医组合物，每种组合物包含多个等电点高于约6.0的改良乳生长因子， 大约5000至30,000的范围，牛奶生长因子被瞬时酸化改变。