公开(公告)号：EP1965805B1

公开(公告)日：2009-12-02

申请号：EP06829733.2

申请日：2006-10-31

申请人： Galapagos SAS

发明人： DEPREZ, Pierre ,  JARY, Helène ,  TEMAL, Taoues

IPC分类号： A61K31/5375 ,  A61K31/5377 ,  C07D213/38 ,  C07D213/75 ,  C07D213/80 ,  C07D213/82 ,  C07D217/22 ,  C07D231/52 ,  C07D231/56 ,  C07D235/14 ,  C07D235/30 ,  C07D239/46 ,  C07D257/04 ,  C07D261/08 ,  C07D261/20

CPC分类号： C07D295/13 ,  C07D209/08 ,  C07D209/88 ,  C07D213/40 ,  C07D213/70 ,  C07D213/75 ,  C07D213/80 ,  C07D213/82 ,  C07D217/02 ,  C07D231/22 ,  C07D231/40 ,  C07D231/52 ,  C07D231/56 ,  C07D235/18 ,  C07D235/30 ,  C07D239/47 ,  C07D239/48 ,  C07D241/20 ,  C07D257/04 ,  C07D261/08 ,  C07D261/14 ,  C07D261/18 ,  C07D261/20 ,  C07D263/32 ,  C07D263/48 ,  C07D277/28 ,  C07D277/66 ,  C07D285/08 ,  C07D285/135 ,  C07D295/125 ,  C07D307/52 ,  C07D307/88 ,  C07D317/66 ,  C07D319/08 ,  C07D319/18 ,  C07D333/20 ,  C07D333/28 ,  C07D333/38 ,  C07D333/68 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04

摘要： The present invention provides compounds of formula (I): in which Y is oxygen or sulphur; R1 and R”1 are optionally substituted aryl, heteroaryl or a fused ring structure, R2 and R'2 are each H, or optionally substituted alkyl, alkylaminoalkyl or dialkylaminoalkyl, or R2 and R'2 and their N form a saturated or unsaturated optionally substituted heterocycle, R3 represents a group of formula -(CH2)P-Ar-Rn, wherein p is 0 or 1 and, when p is 1, is optionally substituted, Ar is aryl or heteroaryl, and each R is H, halogen; hydroxyl; trifiuoromethyl; linear and branched alkyl, alkenyl, alkynyl, and alkoxyl groups, all optionally further substituted by one or more of hydroxy groups, halogen atoms, alkoxy groups, amino groups, and alkylthio groups; linear and branched alkoxyl groups; linear and branched thioalkyl groups; aryl groups; aralkyl groups; aralkoxy groups; aryloxy groups; perfluoroalkyl; -CN; -NR4R5, -C(=X)NR4R5,-O-C(=X)NR4R5, -SO2NR4R5, - Alk-NR4R5, -NZC(=X)(NH)qR6, -Alk-NZC(=X)(NH)qR6, -C(=X)R6, -Alk-C(=X)(NH)qR6, -NHSO2R7, -SO2R7, -SOR7, -SR7, or is a saturated or unsaturated heterocyclyl group, and salts and esters thereof, are useful in the treatment of conditions susceptible to modulating ion channels, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.

公开(公告)号：EP1874765B1

公开(公告)日：2012-03-07

申请号：EP06724709.8

申请日：2006-04-24

申请人： Galapagos SAS

发明人： DEPREZ, Pierre ,  JARY, Helène ,  TEMAL, Taoues

IPC分类号： C07D417/12 ,  C07D413/12 ,  C07D417/14

CPC分类号： C07D263/58 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

摘要： The present invention provides compounds of formula (I): in which R1, R'1, R2, R'2, R3, Y and G have the meanings given in the description, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.