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公开(公告)号：EP2499161B1
公开(公告)日：2017-09-06
申请号：EP10778877.0
申请日：2010-11-11
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael
IPC分类号： C07K16/28 , C07K14/705 , A61P35/00 , A61K39/00 , C07K16/30
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译： 本发明提供了用作治疗和/或预防与表达紧密连接蛋白-6（CLDN6）的细胞有关的疾病的抗体，所述疾病包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌 ，皮肤癌，恶性黑色素瘤，头颈部癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，宫颈癌，睾丸癌和子宫癌。
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公开(公告)号：EP2707390B1
公开(公告)日：2015-12-30
申请号：EP12715856.6
申请日：2012-04-20
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael , WEICHEL, Michael
IPC分类号： A61P35/00 , C07K16/30 , A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/30 , A61K39/39591 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
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公开(公告)号：EP2920209A1
公开(公告)日：2015-09-23
申请号：EP13789492.9
申请日：2013-11-12
申请人： BioNTech AG , Ganymed Pharmaceuticals AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , STADLER, Christiane , HOLLAND, Julia , BÄHR-MAHMUD, Hayat , BEISSERT, Tim , PLUM, Laura , LE GALL, Fabrice , JENDRETZKI, Arne , FIEDLER, Markus
IPC分类号： C07K16/28
摘要： The present invention provides binding agents that contain a binding domain that is specific for CD3 allowing binding to T cells and a binding domain that is specific for a tumor- associated claudin molecule and methods of using these binding agents or nucleic acids encoding therefor for treating cancer.
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4.发明公开
公开(公告)号：EP2069538A1
公开(公告)日：2009-06-17
申请号：EP07818850.5
申请日：2007-10-09
申请人： Ganymed Pharmaceuticals AG , Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , A61K31/7088 , A61K39/39558 , A61K47/6807 , C07K16/28 , C07K16/2866 , C07K16/40 , C07K2317/76 , C12N15/1138 , C12N15/8218 , C12N2310/11 , C12N2310/14 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , G01N33/57484 , G01N33/57492 , G01N2333/715 , G01N2333/7158 , G01N2333/916
摘要： The present invention relates to methods which make possible to assess and/or prognose a cancer disease, the metastatic behaviour of a cancer disease and/or the occurrence of a relapse of cancer according to the levels of expression of TPTE and CXCR4. In particular, the methods of the invention make possible to assess and/or prognose the occurrence of cancer metastasis, in particular distant metastasis. Preferably, the methods of the invention allow to discriminate malign from benign conditions.
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5.发明公开ANTIBODIES FOR TREATMENT OF CANCER EXPRESSING CLAUDIN 6 审中-公开安东尼奥ZUR BEHANDLUNG VON CLAUDIN 6 EXPRIMIERENDEM KARZINOM
公开(公告)号：EP3026064A1
公开(公告)日：2016-06-01
申请号：EP15201110.2
申请日：2012-04-20
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael , WEICHEL, Michael
IPC分类号： C07K16/30 , A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/30 , A61K39/39591 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor- related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLDN6的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌，皮肤癌，恶性肿瘤 黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。
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6.发明公开THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CANCER 审中-公开随着对癌症紧密连接蛋白18.2的治疗抗体治疗
公开(公告)号：EP2976360A1
公开(公告)日：2016-01-27
申请号：EP14714586.6
申请日：2014-03-17
申请人： Ganymed Pharmaceuticals AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395 , A61P35/00
摘要： The present invention generally provides a therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN 18.2, in particular cancer diseases such as gastroesophageal cancer. Data are presented demonstrating that administration of an anti-CLDN18.2 antibody to human patients with gastroesophageal cancer is safe and well-tolerated up to a dose of at least 1000 mg/m2. Furthermore, data are presented demonstrating that the antibody is fully functional in these patients to execute anti-tumor cell effects and evidence for antitumoral activity was obtained.
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公开(公告)号：EP1924600B1
公开(公告)日：2013-08-28
申请号：EP06791878.9
申请日：2006-09-06
申请人： Ganymed Pharmaceuticals AG , Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , USENER, Dirk
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/5256 , A61K2039/54 , A61K2039/57 , A61K2039/572 , C07K14/4748 , C07K16/2803 , C07K16/30 , C07K2317/34 , C12Q1/6886 , C12Q2600/158 , G01N33/574
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公开(公告)号：EP1948693B1
公开(公告)日：2013-03-20
申请号：EP06818817.6
申请日：2006-11-24
申请人： Ganymed Pharmaceuticals AG , Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten
发明人： SAHIN, Ugur , TÜRECI, Özlem , USENER, Dirk , FRITZ, Stefan , UHEREK, Christoph , BRANDENBURG, Gunda , GEPPERT, Harald-Gerhard , SCHRÖDER, Anja Kristina , THIEL, Philippe
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6807 , A61K47/6809 , A61K47/6813 , A61K47/6821 , A61K47/6823 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K51/1063 , A61K2039/505 , C07K16/28 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
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公开(公告)号：EP2398497A1
公开(公告)日：2011-12-28
申请号：EP10705807.5
申请日：2010-02-18
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael
IPC分类号： A61K39/395
CPC分类号： C07K16/3046 , A61K2039/505 , C07K2317/34 , G01N33/57419 , G01N33/57446
摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of colorectal, in particular colonic, and gastric tumor tissues and colorectal, in particular colonic, and gastric tissues, and which represent targets for therapy or diagnosis of such tumor diseases in a subject.
摘要翻译： 本发明涉及鉴定结肠直肠特别是结肠和胃肿瘤组织和结肠直肠特别是结肠和胃组织的特征的核酸和氨基酸序列，并且其代表用于治疗或诊断这种肿瘤的靶标 受试者中的疾病。
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10.发明公开MONOCLONAL ANTIBODIES AGAINST CLAUDIN-18 FOR TREATMENT OF CANCER 有权MONOKLONALEANTIKÖRPERGEGEN CLAUDIN-18 ZUR BEHANDLUNG VON KREBS
公开(公告)号：EP2152754A2
公开(公告)日：2010-02-17
申请号：EP08758782.0
申请日：2008-05-27
发明人： SAHIN, Ugur , TÜRECI, Özlem , BRANDENBURG, Gunda , USENER, Dirk
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , C12N5/12 , A61K47/48
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌，头部 - 癌症，胆囊癌及其转移灶。
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