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公开(公告)号：EP2638031B9
公开(公告)日：2020-01-08
申请号：EP11782588.5
申请日：2011-11-09
申请人： Genentech, Inc.
发明人： BAKER-GLENN, Charles , BURDICK, Daniel Jon , CHAMBERS, Mark , CHEN, Huifen , ESTRADA, Anthony , SWEENEY, Zachary Kevin , CHAN, Bryan K.
IPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , A61K31/506 , A61P25/16
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公开(公告)号：EP3075730B1
公开(公告)日：2018-10-24
申请号：EP16155153.6
申请日：2011-06-01
申请人： Genentech, Inc.
发明人： BAKER-GLENN, Charles , BURDICK, Daniel Jon , CHAMBERS, Mark , CHAN, Bryan K. , CHEN, Huifen , ESTRADA, Anthony , GUNZNER, Janet L. , SHORE, Daniel , SWEENEY, Zachary Kevin , WANG, Shumei , ZHAO, Guiling
IPC分类号： C07D403/14 , C07D473/16 , A61K31/52 , A61P25/16
CPC分类号： C07D413/14 , C07D403/14 , C07D413/12 , C07D473/16 , C07D498/06 , C07D498/08
摘要： Compounds of the formula I or pharmaceutically acceptable salts thereof, wherein m, n. X, R 1 , R 2 , R 3 , R 5 , R 6 and R 7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
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公开(公告)号：EP3590933A1
公开(公告)日：2020-01-08
申请号：EP19184916.5
申请日：2011-11-09
申请人： GENENTECH, INC.
发明人： BAKER-GLENN, Charles , BURDICK, Daniel John , CHAMBERS, Mark , CHEN, Huifen , ESTRADA, Anthony , SWEENEY, Zachary Kevin , CHAN, Bryan K.
IPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , A61K31/506 , A61P25/16 , A61P25/00
摘要： Compounds of the formula I:
or pharmaceutically acceptable salts thereof,
wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.-
公开(公告)号：EP3124483B1
公开(公告)日：2019-07-10
申请号：EP16180927.2
申请日：2011-11-09
申请人： Genentech, Inc.
发明人： BAKER-GLENN, Charles , BURDICK, Daniel Jon , CHAMBERS, Mark , CHEN, Huifen , ESTRADA, Anthony , SWEENEY, Zachary Kevin , CHAN, Bryan K.
IPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , A61K31/506 , A61P25/16
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公开(公告)号：EP2638031B1
公开(公告)日：2017-10-11
申请号：EP11782588.5
申请日：2011-11-09
申请人： Genentech, Inc.
发明人： BAKER-GLENN, Charles , BURDICK, Daniel Jon , CHAMBERS, Mark , CHEN, Huifen , ESTRADA, Anthony , SWEENEY, Zachary Kevin , CHAN, Bryan K.
IPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , A61K31/506 , A61P25/16
摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
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6.发明授权2-PHENYLAMINOPYRIMIDINE DERIVATIVES AS KINASE LRRK2 MODULATORS FOR THE TREATMENT OF PARKINSON'S DISEASE 有权作为激酶LRRK2调节剂的2-苯基氨基嘧啶衍生物治疗帕金森氏病
公开(公告)号：EP2785699B1
公开(公告)日：2017-09-06
申请号：EP12791761.5
申请日：2012-11-28
申请人： Genentech, Inc.
发明人： BAKER-GLENN, Charles , BURDICK, Daniel Jon , CHAMBERS, Mark , CHAN, Bryan K. , CHEN, Huifen , ESTRADA, Anthony , GUNZNER-TOSTE, Janet , SHORE, Daniel , SWEENEY, Zachary , WANG, Shumei , ZHAO, Guiling
IPC分类号： C07D239/47 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D487/04 , C07D498/08 , C07D491/107 , A61K31/505 , A61K31/506 , A61P25/16
CPC分类号： C07D498/18 , C07D239/47 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D487/04 , C07D491/107 , C07D498/08 , C07D498/10
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公开(公告)号：EP2844658B1
公开(公告)日：2019-03-20
申请号：EP13718860.3
申请日：2013-04-30
申请人： Genentech, Inc.
发明人： BAKER-GLENN, Charles , CHAN, Bryan K. , DOTSON, Jennafer , ESTRADA, Anthony , HEFFRON, Timothy , LYSSIKATOS, Joseph , SWEENEY, Zachary Kevin
IPC分类号： C07D471/04 , C07D487/04 , C07D498/04 , C07D498/20 , A61K31/506
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公开(公告)号：EP2807152B1
公开(公告)日：2017-07-19
申请号：EP12797826.0
申请日：2012-11-28
申请人： Genentech, Inc.
发明人： BAKER-GLENN, Charles , CHAMBERS, Mark , CHAN, Bryan K. , CHEN, Huifen , ESTRADA, Anthony , SHORE, David , SWEENEY, Zachary
IPC分类号： C07D239/42 , C07D239/48 , A61K31/505
CPC分类号： C07D413/12 , C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12
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公开(公告)号：EP2844652B1
公开(公告)日：2019-03-13
申请号：EP13720901.1
申请日：2013-04-30
申请人： Genentech, Inc.
发明人： BAKER-GLENN, Charles , BURDICK, Daniel Jon , CHAMBERS, Mark , CHAN, Bryan K. , CHEN, Huifen , ESTRADA, Anthony , SWEENEY, Zachary Kevin
IPC分类号： C07D403/12 , C07D413/14 , C07D403/14 , C07D407/14 , C07D405/14 , A61K31/506
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公开(公告)号：EP2785709B1
公开(公告)日：2017-05-10
申请号：EP12791198.0
申请日：2012-11-28
申请人： Genentech, Inc.
发明人： BAKER-GLENN, Charles , CHAMBERS, Mark , CHAN, Bryan K. , ESTRADA, Anthony , SWEENEY, Zachary Kevin
IPC分类号： C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , A61K31/553 , A61K31/538 , A61K31/506 , A61K31/5377 , A61P25/16
CPC分类号： A61K31/506 , C07D239/47 , C07D239/48 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D498/08
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