公开(公告)号：EP2435438A1

公开(公告)日：2012-04-04

申请号：EP10720979.3

申请日：2010-05-26

申请人： Genentech, Inc. ,  F.Hoffmann-La Roche AG

发明人： CASTANEDO, Georgette ,  CHAN, Bryan ,  GOLDSTEIN, David Michael ,  KONDRU, Rama K. ,  LUCAS, Matthew C. ,  PALMER, Wylie Solang ,  PRICE, Stephen ,  SAFINA, Brian ,  SAVY, Pascal Pierre Alexandre ,  SEWARD, Eileen Mary ,  SUTHERLIN, Daniel P. ,  SWEENEY, Zachary Kevin

IPC分类号： C07D487/04 ,  C07D491/04 ,  C07D513/04 ,  A61K31/519 ,  A61P35/00 ,  A61P9/00 ,  A61P29/00 ,  A61P25/00

CPC分类号： C07D513/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： Formula (I) ((Ia) and (Ib)) compounds wherein (i) X
1 is N and X
2 is S, (ii) X
1 is CR
7 and X
2 is S, (iii) X
1 is N and X
2 is NR
2 , or (iv) X
1 is CR
7 and X
2 is O, including stereoisomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological, and cancer. Methods of using compounds of Formula (I) for
in vitro, in situ , and
in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

公开(公告)号：EP2638031B9

公开(公告)日：2020-01-08

申请号：EP11782588.5

申请日：2011-11-09

申请人： Genentech, Inc.

发明人： BAKER-GLENN, Charles ,  BURDICK, Daniel Jon ,  CHAMBERS, Mark ,  CHEN, Huifen ,  ESTRADA, Anthony ,  SWEENEY, Zachary Kevin ,  CHAN, Bryan K.

IPC分类号： C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/506 ,  A61P25/16

公开(公告)号：EP3075730B1

公开(公告)日：2018-10-24

申请号：EP16155153.6

申请日：2011-06-01

申请人： Genentech, Inc.

发明人： BAKER-GLENN, Charles ,  BURDICK, Daniel Jon ,  CHAMBERS, Mark ,  CHAN, Bryan K. ,  CHEN, Huifen ,  ESTRADA, Anthony ,  GUNZNER, Janet L. ,  SHORE, Daniel ,  SWEENEY, Zachary Kevin ,  WANG, Shumei ,  ZHAO, Guiling

IPC分类号： C07D403/14 ,  C07D473/16 ,  A61K31/52 ,  A61P25/16

CPC分类号： C07D413/14 ,  C07D403/14 ,  C07D413/12 ,  C07D473/16 ,  C07D498/06 ,  C07D498/08

摘要： Compounds of the formula I or pharmaceutically acceptable salts thereof, wherein m, n. X, R 1 , R 2 , R 3 , R 5 , R 6 and R 7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

公开(公告)号：EP2844658B1

公开(公告)日：2019-03-20

申请号：EP13718860.3

申请日：2013-04-30

申请人： Genentech, Inc.

发明人： BAKER-GLENN, Charles ,  CHAN, Bryan K. ,  DOTSON, Jennafer ,  ESTRADA, Anthony ,  HEFFRON, Timothy ,  LYSSIKATOS, Joseph ,  SWEENEY, Zachary Kevin

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D498/20 ,  A61K31/506

公开(公告)号：EP2844652B1

公开(公告)日：2019-03-13

申请号：EP13720901.1

申请日：2013-04-30

申请人： Genentech, Inc.

发明人： BAKER-GLENN, Charles ,  BURDICK, Daniel Jon ,  CHAMBERS, Mark ,  CHAN, Bryan K. ,  CHEN, Huifen ,  ESTRADA, Anthony ,  SWEENEY, Zachary Kevin

IPC分类号： C07D403/12 ,  C07D413/14 ,  C07D403/14 ,  C07D407/14 ,  C07D405/14 ,  A61K31/506

公开(公告)号：EP2785709B1

公开(公告)日：2017-05-10

申请号：EP12791198.0

申请日：2012-11-28

申请人： Genentech, Inc.

发明人： BAKER-GLENN, Charles ,  CHAMBERS, Mark ,  CHAN, Bryan K. ,  ESTRADA, Anthony ,  SWEENEY, Zachary Kevin

IPC分类号： C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  A61K31/553 ,  A61K31/538 ,  A61K31/506 ,  A61K31/5377 ,  A61P25/16

CPC分类号： A61K31/506 ,  C07D239/47 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D498/08

公开(公告)号：EP3590933A1

公开(公告)日：2020-01-08

申请号：EP19184916.5

申请日：2011-11-09

申请人： GENENTECH, INC.

发明人： BAKER-GLENN, Charles ,  BURDICK, Daniel John ,  CHAMBERS, Mark ,  CHEN, Huifen ,  ESTRADA, Anthony ,  SWEENEY, Zachary Kevin ,  CHAN, Bryan K.

IPC分类号： C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/506 ,  A61P25/16 ,  A61P25/00

摘要： Compounds of the formula I:

or pharmaceutically acceptable salts thereof,
wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

公开(公告)号：EP3124483B1

公开(公告)日：2019-07-10

申请号：EP16180927.2

申请日：2011-11-09

申请人： Genentech, Inc.

发明人： BAKER-GLENN, Charles ,  BURDICK, Daniel Jon ,  CHAMBERS, Mark ,  CHEN, Huifen ,  ESTRADA, Anthony ,  SWEENEY, Zachary Kevin ,  CHAN, Bryan K.

IPC分类号： C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/506 ,  A61P25/16

公开(公告)号：EP2638031B1

公开(公告)日：2017-10-11

申请号：EP11782588.5

申请日：2011-11-09

申请人： Genentech, Inc.

发明人： BAKER-GLENN, Charles ,  BURDICK, Daniel Jon ,  CHAMBERS, Mark ,  CHEN, Huifen ,  ESTRADA, Anthony ,  SWEENEY, Zachary Kevin ,  CHAN, Bryan K.

IPC分类号： C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/506 ,  A61P25/16

摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.