专利检索 ap:("Genentech, Inc.") AND inv:"CHOCHRAN, Andrea, G." 第 1 页

1.

发明授权
A STRUCTURED PEPTIDE SCAFFOLD FOR DISPLAYING TURN LIBRARIES ON PHAGE 有权
标题翻译：结构化肽框架旋转文库在噬菌体ISSUANCE

公开(公告)号：EP1187914B1

公开(公告)日：2005-05-25

申请号：EP00941412.9

申请日：2000-06-13

申请人： Genentech, Inc.

发明人： CHOCHRAN, Andrea, G. , SKELTON, Nicholas, J. , STAROVASNIK, Melissa, A.

IPC分类号： C12N15/10 , C07K1/04 , C07K14/705 , C07K14/71 , G01N33/68

CPC分类号： C07K1/047 , C07K7/06 , C07K7/08 , C07K14/70514 , C07K14/70535 , C07K14/71 , C12N15/1037 , C40B40/02

2.

发明公开
A STRUCTURED PEPTIDE SCAFFOLD FOR DISPLAYING TURN LIBRARIES ON PHAGES 有权
标题翻译：结构化肽框架旋转文库在噬菌体ISSUANCE

公开(公告)号：EP1187914A1

公开(公告)日：2002-03-20

申请号：EP00941412.9

申请日：2000-06-13

申请人： Genentech, Inc.

发明人： CHOCHRAN, Andrea, G. , SKELTON, Nicholas, J. , STAROVASNIK, Melissa, A.

IPC分类号： C12N15/10 , C07K1/04 , C07K14/705 , C07K14/71 , G01N33/68

CPC分类号： C07K1/047 , C07K7/06 , C07K7/08 , C07K14/70514 , C07K14/70535 , C07K14/71 , C12N15/1037 , C40B40/02

摘要： The invention is directed to a model system for structure-activity analysis of peptide or protein molecules involved in important biological processes. Provided by the invention are combinatorial peptide libraries comprising disulfide-constrained cyclic peptides with sequences favorable for energy stabilized conformations. A preferred embodiment of the invention is directed to peptides containing β-turn tetrapeptide that form structured β-hairpin scaffold in solution. Methods of selecting and using such peptides are provided herein, which are useful for mimicking in vivo molecular interactions and designing therapeutic agents. Thus, the invention has profound utility for biological studies and drug development.