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公开(公告)号：EP2471816A1
公开(公告)日：2012-07-04
申请号：EP11191823.1
申请日：2007-08-17
申请人： Genentech, Inc.
发明人： Fuh, Germaine , Bostrom, Jenny, M.
CPC分类号： C07K16/32 , C07K16/22 , C07K16/2878 , C07K16/4283 , C07K16/468 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/73
摘要： The invention provides a method of making dual-specific antibodies by randomizing the sequence of the variable light chain of an antibody with a first specificity and selecting for antibodies with the first and a second specificity.
摘要翻译： 本发明提供了通过使具有第一特异性的抗体的可变轻链的序列随机化并选择具有第一和第二特异性的抗体来制备双特异性抗体的方法。
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公开(公告)号：EP2851372A1
公开(公告)日：2015-03-25
申请号：EP14191456.4
申请日：2008-12-01
申请人： Genentech, Inc.
发明人： Fuh, Germaine , Lee, Chingwei, V.
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , G01N33/6893 , G01N2333/475
摘要： The invention herein provides isolated antibodies that bind to VEGF. The invention further provides methods of making anti-VEGF antibodies, and polynucleotides encoding anti-VEGF antibodies.
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公开(公告)号：EP2420512A2
公开(公告)日：2012-02-22
申请号：EP10009691.6
申请日：2004-07-30
申请人： Genentech, Inc.
发明人： Fuh, Germaine , Gerber, Hanspeter , Liang, Wei-Ching , Fellouse, Frederic A. , Sidhu, Sachdev S. , Wiesmann, Christian
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
摘要： Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the synthetic antibodies in research, diagnostic and therapeutic applications.
摘要翻译： 公开了抗VEGF抗体及其变体，包括对VEGF结合具有高亲和力的抗体。 还提供了使用噬菌体展示技术与初始文库产生和选择具有期望的结合和其他生物活性的抗VEGF抗体的方法。 进一步考虑的是合成抗体在研究，诊断和治疗应用中的用途。
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公开(公告)号：EP2083018A3
公开(公告)日：2010-05-05
申请号：EP09004416.5
申请日：2004-04-16
申请人： Genentech, Inc.
发明人： Ackerly, Heidi , Ashkenazi, Avi , Eberhard, David , Frantz, Gretchen , French, Dorothy , Fuh, Germaine , Hongo, Jo-Anne , Lee, Chingwei , Marsters, Scot , Pitti, Robert , Raab, Helga , Soroceanu, Liliana , Varfolomeev, Evgeny , Wolf, Beni
IPC分类号： C07K16/44 , C07K14/47 , G01N33/53 , A61P35/00 , C12N15/12 , C12N15/63 , C12N15/09 , A61K31/7088 , C07K19/00 , C07K16/46 , A61K39/395 , G01N33/574
CPC分类号： C07K16/32 , C07K16/22 , C07K16/4283 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.
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公开(公告)号：EP2851372B1
公开(公告)日：2017-02-01
申请号：EP14191456.4
申请日：2008-12-01
申请人： Genentech, Inc.
发明人： Fuh, Germaine , Lee, Chingwei, V.
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , G01N33/6893 , G01N2333/475
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公开(公告)号：EP2420512A3
公开(公告)日：2013-08-21
申请号：EP10009691.6
申请日：2004-07-30
申请人： Genentech, Inc.
发明人： Fuh, Germaine , Gerber, Hanspeter , Liang, Wei-Ching , Fellouse, Frederic A. , Sidhu, Sachdev S. , Wiesmann, Christian
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
摘要： Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the synthetic antibodies in research, diagnostic and therapeutic applications.
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7.发明公开Compositions and methods relating to STOP-1 审中-公开Zusammensetzungen und Verfahren mit Bezug zu STOP-1
公开(公告)号：EP2083018A2
公开(公告)日：2009-07-29
申请号：EP09004416.5
申请日：2004-04-16
申请人： Genentech, Inc.
发明人： Ackerly, Heidi , Ashkenazi, Avi , Eberhard, David , Frantz, Gretchen , French, Dorothy , Fuh, Germaine , Hongo, Jo-Anne , Lee, Chingwei , Marsters, Scot , Pitti, Robert , Raab, Helga , Soroceanu, Liliana , Varfolomeev, Evgeny , Wolf, Beni
IPC分类号： C07K16/44 , C07K14/47 , G01N33/53 , A61P35/00 , C12N15/12 , C12N15/63 , C12N15/09 , A61K31/7088 , C07K19/00
CPC分类号： C07K16/32 , C07K16/22 , C07K16/4283 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.
摘要翻译： 本发明提供可用于治疗和预防疾病和用于医学诊断和研究的新型多肽，抗体，拮抗剂，激动剂，增效剂，核酸分子，与STOP-1多肽相关的组合物和方法。 本发明还提供了与本文所述方法有用的特异性结合STOP-1的抗体的共有序列和特异性序列。
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