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公开(公告)号：EP2344543A2
公开(公告)日：2011-07-20
申请号：EP09740235.8
申请日：2009-10-14
发明人： BENDER, Brendan C. , EPPLER, Steve , HEGDE, Priti , JUMBE, Nelson L. , MERCHANT, Mark , PETERSON, Amy C. , REYES, Arthur E. II , XIANG, Hong
CPC分类号： C07K16/2863 , A61K39/39558 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/32 , C07K2317/73 , C07K2317/76 , A61K2300/00
摘要： The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention relates to therapies for the treatment of pathological conditions, such as cancer.
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2.发明公开BIOMARKERS AND METHODS OF TREATING PD-1 AND PD-L1 RELATED CONDITIONS 有权生物标志物VERFAHREN ZUR BEHANDLUNG VON PD-1 UND PD-L1-VERWANDTEN LEIDEN
公开(公告)号：EP2972373A2
公开(公告)日：2016-01-20
申请号：EP14714119.6
申请日：2014-03-12
IPC分类号： G01N33/574
CPC分类号： C07K16/2827 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C12Q1/6886 , G01N33/57484 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/5412 , G01N2333/70532 , G01N2800/52 , G06Q30/0251
摘要： Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.
摘要翻译： 本文提供了用于治疗诸如癌症的病理状况的生物标志物，以及使用PD-1 / PD-L1途径拮抗剂的方法。 特别地，提供了用于癌症中患者选择和预后的生物标志物，以及治疗性治疗方法，制造物品及其制备方法，诊断试剂盒，检测方法和与其相关的广告方法。
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公开(公告)号：EP4155415A1
公开(公告)日：2023-03-29
申请号：EP22191450.0
申请日：2017-02-27
发明人： BOURGON, Richard , FABRIZIO, David , FINE, Gregg , FRAMPTON, Garrett, M. , HEGDE, Priti , MARIATHASAN, Sanjeev , STEPHENS, Philip J. , SUN, James, Xin , YELENSKY, Roman
IPC分类号： C12Q1/68
摘要： The present invention provides therapeutic and diagnostic methods and compositions for cancer, for example, bladder cancer. The invention provides methods of treating bladder cancer, methods of determining whether a patient suffering from bladder cancer is likely to respond to treatment comprising a PD-L1 axis binding antagonist, methods of predicting responsiveness of a patient suffering bladder cancer to treatment comprising a PD-L1 axis binding antagonist, and methods of selecting a therapy for a patient suffering from bladder cancer, based on somatic mutation levels of genes of the invention (e.g., somatic mutation levels in a tumor sample obtained from the patient.
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公开(公告)号：EP3523451A1
公开(公告)日：2019-08-14
申请号：EP17797468.0
申请日：2017-10-06
发明人： SHAMES, David , FABRIZIO, David , FRAMPTON, Garrett, M. , HEGDE, Priti , KOWANETZ, Marcin , STEPHENS, Philip, J. , SUN, James, Xin , YELENSKY, Roman , ZOU, Wei
IPC分类号： C12Q1/68 , A61K39/395 , A61P35/00 , C07K16/28
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公开(公告)号：EP3423596A1
公开(公告)日：2019-01-09
申请号：EP17709892.8
申请日：2017-02-27
发明人： BOURGON, Richard , FABRIZIO, David , FINE, Gregg , FRAMPTON, Garrett, M. , HEGDE, Priti , MARIATHASAN, Sanjeev , STEPHENS, Philip J. , SUN, James, Xin , YELENSKY, Roman
IPC分类号： C12Q1/68
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