公开(公告)号：EP1922410A2

公开(公告)日：2008-05-21

申请号：EP06787655.7

申请日：2006-07-18

申请人： Genentech, Inc. ,  Lexicon Pharmaceuticals, Inc.

发明人： HORNER, Allison Anne Byers ,  COMBS, Katherin, E. ,  CULBERTSON, Ling Ling ,  DELMAS-MATA, Juan ,  DESAUVAGE, Frederic ,  FAN, Liangfen ,  FRANTZ, Gretchen ,  GREEN, Leslie Jane ,  MASSEY, Erin Marie ,  MCLAIN, Dina Rebecca ,  MONTGOMERY, Charles A. ,  PAYNE, Bobby Joe ,  PEALE, Franklin, Jr. ,  PHILLIPS, Heidi ,  ROHRER, Michelle ,  SHI, Zheng-Zheng ,  SPARKS, Mary Jean ,  STALA, Joy Anne ,  TANG, Tracy Tzu-Ling ,  VOGEL, Peter ,  WANG, Ching-Yun ,  SEVAUX, Tracy Ellen Willis ,  XIONG, Wen

IPC分类号： C12N15/85 ,  C12N5/06 ,  A01K67/027 ,  A61K49/00 ,  A61K38/00

CPC分类号： C12N15/8509 ,  A01K2217/075 ,  A01K2267/0306 ,  A01K2267/0362 ,  A01K2267/0375

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

公开(公告)号：EP1988768A2

公开(公告)日：2008-11-12

申请号：EP07756828.5

申请日：2007-02-09

申请人： Genentech, Inc. ,  Lexicon Pharmaceuticals, Inc.

发明人： BOLLINGER, Kristi Rae ,  HORNER, Allison Anne Byers ,  COMBS, Katherin, E. ,  CULBERTSON, Ling Ling ,  CUNNINGHAM, Jaime-jo ,  DESAUVAGE, Frederic ,  EDWARDS, Joel ,  GIRGIS, Rosemary ,  GREEN, Leslie ,  MCLAIN, Dina Rebecca ,  MINZE, Laurie Jeanette ,  MONTGOMERY, Charles, A. ,  PAYNE, Bobby Joe ,  PHILLIPS, Heidi ,  SHI, Zheng-zheng ,  SPARKS, Mary Jean ,  STALA, Joy ,  TANG, Tracy Tzu-ling ,  TOWNSEND, Teresa Gail ,  VOGEL, Peter ,  SEVAUX, Tracy Ellen Willis

IPC分类号： A01K67/027 ,  A61K39/395 ,  C07K14/47 ,  C07K14/515 ,  C07K16/18 ,  G01N33/50

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

公开(公告)号：EP1962584A2

公开(公告)日：2008-09-03

申请号：EP06849173.7

申请日：2006-11-16

申请人： GENENTECH, INC. ,  Lexicon Pharmaceuticals, Inc.

发明人： HORNER, Allison, Anne, Byers ,  COMBS, Katherin E. ,  DESAUVAGE, Frederic ,  FAN, Liangfen ,  FILVAROFF, Ellen ,  IRVING, Bryan ,  JUNUTULA, Jagath Reddy ,  MASSEY, Erin Marie ,  MCLAIN, Dina Rebecca ,  MINZE, Laurie Jeanette ,  MONTGOMERY, Charles, A. ,  PAYNE, Bobby Joe ,  PHILLIPS, Heidi ,  RANGEL, Carolina ,  SHI, Zheng-zheng ,  SPARKS, Mary Jean ,  STALA, Joy, Anne ,  TOWNSEND, Teresa Gail ,  VOGEL, Peter ,  SEVAUX, Tracy Ellen Willis

IPC分类号： A01K67/027 ,  A61K49/00

CPC分类号： C12Q1/6883 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A61K49/0008 ,  C12N15/8509 ,  C12Q2600/158

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO1016, PRO474, PRO5238, PRO1069, PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.