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1.发明公开
公开(公告)号：EP1871163A2
公开(公告)日：2008-01-02
申请号：EP06770779.4
申请日：2006-05-18
发明人： COMBS, Katherin , CULBERTSON, Ling Ling , DESAUVAGE, Frederic , DING, Zhiyong , EDWARDS, Joel , GIRGIS, Rosemary , JUNGE, Harald , JUNUTULA, Jagath Reddy , MASSEY, Erin Marie , MCLAIN, Dina Rebecca , MONTGOMERY, Charles A. , PAYNE, Bobby Joe , PHILLIPS, Heidi , QIAN, Ni Nancy , RANGEL, Carolina , SHI, Zheng-Zheng , SPARKS, Mary Jean , STALA, Joy , VOGEL, Peter , SEVAUX, Tracy, Ellen, Willis , YE, Weilan , HORNER, Allison, Ann, Byers
IPC分类号： A01K67/027 , C12N15/85 , G01N33/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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2.发明公开
公开(公告)号：EP1922410A2
公开(公告)日：2008-05-21
申请号：EP06787655.7
申请日：2006-07-18
发明人： HORNER, Allison Anne Byers , COMBS, Katherin, E. , CULBERTSON, Ling Ling , DELMAS-MATA, Juan , DESAUVAGE, Frederic , FAN, Liangfen , FRANTZ, Gretchen , GREEN, Leslie Jane , MASSEY, Erin Marie , MCLAIN, Dina Rebecca , MONTGOMERY, Charles A. , PAYNE, Bobby Joe , PEALE, Franklin, Jr. , PHILLIPS, Heidi , ROHRER, Michelle , SHI, Zheng-Zheng , SPARKS, Mary Jean , STALA, Joy Anne , TANG, Tracy Tzu-Ling , VOGEL, Peter , WANG, Ching-Yun , SEVAUX, Tracy Ellen Willis , XIONG, Wen
IPC分类号： C12N15/85 , C12N5/06 , A01K67/027 , A61K49/00 , A61K38/00
CPC分类号： C12N15/8509 , A01K2217/075 , A01K2267/0306 , A01K2267/0362 , A01K2267/0375
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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公开(公告)号：EP1863340A2
公开(公告)日：2007-12-12
申请号：EP06736637.7
申请日：2006-02-27
发明人： HORNER, Allison Anne Byers , CLARKE, Catherine Anne B. , COMBS, Katherin E. , DESAUVAGE, Frederic , EDWARDS, Joel , GODOWSKI, Paul , GRANT, Deanna , HUANG, Wenhu , KETCHERSIDE, Lorelei Diane , MASSEY, Erin Marie , MONTGOMERY, Charles A. , PAYNE, Bobby Joe , PETERSON, Andrew , QIAN, Ni Nancy , SCHRICK, Jeffrey L. , SHI, Zheng-Zheng , SPARKS, Mary Jean , STALA, Joy , VIATOR, Colleen M. , VOGEL, Peter , YE, Weilan , YEH, Jung-Hua , DING, Zhiyong
IPC分类号： A01K67/027 , C07K14/47 , C07K14/515 , C07K16/18 , G01N33/50 , C12N5/10 , A61K39/395
CPC分类号： C07K14/47 , A01K2217/075 , A61K2039/505 , G01N2500/00
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO1115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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4.发明公开KNOCKOUT MICE FOR PRO1105, PRO1279 OR PRO1783 CODING GENES 审中-公开敲除小鼠FOR PRO1105，PRO1279 OR PRO1783编码基因
公开(公告)号：EP2082052A2
公开(公告)日：2009-07-29
申请号：EP07873515.6
申请日：2007-10-01
发明人： BORROMEO, Mark Dominic , CUNNINGHAM, Jaime-jo , DESAUVAGE, Frederic , FILVAROFF, Ellen , KLAMER, Mark Alan , MINZE, Laurie Jeanette , PAYNE, Bobby Joe , RANGEL, Carolina , SHI, Zheng-zheng , VOGEL, Peter
IPC分类号： C12N15/85 , A01K67/027 , A61K38/00 , C12N5/06
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K49/0008
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO1105, PRO1279 or PRO1783 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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5.发明公开NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO 审中-公开新型GENUNTERBRECHUNGEN，相关组合物和方法
公开(公告)号：EP2010662A2
公开(公告)日：2009-01-07
申请号：EP07863338.5
申请日：2007-04-18
发明人： BOLLINGER, Kristi Rae , DESAUVAGE, Frederic , EDWARDS, Joel A. , GIRGIS, Rosemary , GREEN, Leslie , MINZE, Laurie Jeanette , PAYNE, Bobby Joe , RANGEL, Carolina , SHI, Zheng-zheng , SPARKS, Mary Jean , TANG, Tracy Tzu-ling , VOGEL, Peter
IPC分类号： C12N15/85 , C12N5/00 , C07K16/00 , G01N33/50 , A61K39/395
CPC分类号： C12Q1/6883 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0375 , C07K14/705 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO286, PRO706, PRO1800, PRO4354, PRO6029, PRO9739, PRO20044, PRO28631 or PRO34128 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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6.发明公开
公开(公告)号：EP1988768A2
公开(公告)日：2008-11-12
申请号：EP07756828.5
申请日：2007-02-09
发明人： BOLLINGER, Kristi Rae , HORNER, Allison Anne Byers , COMBS, Katherin, E. , CULBERTSON, Ling Ling , CUNNINGHAM, Jaime-jo , DESAUVAGE, Frederic , EDWARDS, Joel , GIRGIS, Rosemary , GREEN, Leslie , MCLAIN, Dina Rebecca , MINZE, Laurie Jeanette , MONTGOMERY, Charles, A. , PAYNE, Bobby Joe , PHILLIPS, Heidi , SHI, Zheng-zheng , SPARKS, Mary Jean , STALA, Joy , TANG, Tracy Tzu-ling , TOWNSEND, Teresa Gail , VOGEL, Peter , SEVAUX, Tracy Ellen Willis
IPC分类号： A01K67/027 , A61K39/395 , C07K14/47 , C07K14/515 , C07K16/18 , G01N33/50
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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公开(公告)号：EP1962584A2
公开(公告)日：2008-09-03
申请号：EP06849173.7
申请日：2006-11-16
发明人： HORNER, Allison, Anne, Byers , COMBS, Katherin E. , DESAUVAGE, Frederic , FAN, Liangfen , FILVAROFF, Ellen , IRVING, Bryan , JUNUTULA, Jagath Reddy , MASSEY, Erin Marie , MCLAIN, Dina Rebecca , MINZE, Laurie Jeanette , MONTGOMERY, Charles, A. , PAYNE, Bobby Joe , PHILLIPS, Heidi , RANGEL, Carolina , SHI, Zheng-zheng , SPARKS, Mary Jean , STALA, Joy, Anne , TOWNSEND, Teresa Gail , VOGEL, Peter , SEVAUX, Tracy Ellen Willis
IPC分类号： A01K67/027 , A61K49/00
CPC分类号： C12Q1/6883 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K49/0008 , C12N15/8509 , C12Q2600/158
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO1016, PRO474, PRO5238, PRO1069, PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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8.发明公开
公开(公告)号：EP1744620A2
公开(公告)日：2007-01-24
申请号：EP05736493.7
申请日：2005-04-12
发明人： BRENNAN, Jane , DESAUVAGE, Frederic , EDWARDS, Joel , FILVAROFF, Ellen , GREWAL, Iqbal , HUANG, Wenhu , IRVING, Bryan , JUNUTULA, Jagath Reddy , KIRCHHOFER, Daniel J. , MONTGOMERY, Chuck , PAYNE, Bobby Joe , PEALE JR., Franklin , PHILLIPS, Heidi , QIAN, Ni Nancy , SHI, Zheng-Zheng , SPARKS, Mary Jean , STALA, Joy , TANG, Tracy Tzu-Ling , VOGEL, Peter , YE, Weilan
IPC分类号： A01K67/027 , C12N15/85 , G01N33/50 , C12N5/10 , C12N15/12 , C12N15/15 , C12N15/24 , C12N15/52 , C12N15/55 , C12N15/57 , A61K49/00
CPC分类号： A01K67/0275 , A01K67/0278 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K49/0008 , C07K14/4703 , C07K14/705 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO256, PRO34421, PRO334, PRO770, PRO983, PRO1009, PRO1107, PRO1158, PRO1250, PRO1317, PRO4334, PRO4395, PRO49192, PRO9799, PRO21175, PRO19837, PRO21331, PRO23949, PRO697 or PRO1480 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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9.发明公开NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO 审中-公开新型GENUNTERBRECHUNGEN，相关组合物和方法
公开(公告)号：EP1781824A2
公开(公告)日：2007-05-09
申请号：EP05793413.5
申请日：2005-08-23
发明人： BRENNAN, Jane , DESAUVAGE, Frederic , EDWARDS, Joel , HUANG, Wenhu , MONTGOMERY, Chuck , PAYNE, Bobby Joe , SHI, Zheng-Zheng , SPARKS, Mary Jean , VOGEL, Peter , YE, Weilan
IPC分类号： C12Q1/68
CPC分类号： A01K67/0276 , A01K2217/05 , A01K2227/105 , A01K2267/02 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO196, PRO217, PRO231, PRO236, PRO245, PRO246, PRO258, PRO287, PRO328, PRO344, PRO357, PRO526, PRO724, PRO731, PRO732, PRO1003, PRO1104, PRO1151, PRO1244, PRO1298, PRO1313, PRO1570, PRO1886, PRO1891, PRO4409, PRO5725, PRO5994, PRO6097, PRO7425, PRO10102, PRO10282, PRO61709 or PRO779 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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