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公开(公告)号：EP1863340A2
公开(公告)日：2007-12-12
申请号：EP06736637.7
申请日：2006-02-27
发明人： HORNER, Allison Anne Byers , CLARKE, Catherine Anne B. , COMBS, Katherin E. , DESAUVAGE, Frederic , EDWARDS, Joel , GODOWSKI, Paul , GRANT, Deanna , HUANG, Wenhu , KETCHERSIDE, Lorelei Diane , MASSEY, Erin Marie , MONTGOMERY, Charles A. , PAYNE, Bobby Joe , PETERSON, Andrew , QIAN, Ni Nancy , SCHRICK, Jeffrey L. , SHI, Zheng-Zheng , SPARKS, Mary Jean , STALA, Joy , VIATOR, Colleen M. , VOGEL, Peter , YE, Weilan , YEH, Jung-Hua , DING, Zhiyong
IPC分类号： A01K67/027 , C07K14/47 , C07K14/515 , C07K16/18 , G01N33/50 , C12N5/10 , A61K39/395
CPC分类号： C07K14/47 , A01K2217/075 , A61K2039/505 , G01N2500/00
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO1115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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2.发明公开
公开(公告)号：EP1871163A2
公开(公告)日：2008-01-02
申请号：EP06770779.4
申请日：2006-05-18
发明人： COMBS, Katherin , CULBERTSON, Ling Ling , DESAUVAGE, Frederic , DING, Zhiyong , EDWARDS, Joel , GIRGIS, Rosemary , JUNGE, Harald , JUNUTULA, Jagath Reddy , MASSEY, Erin Marie , MCLAIN, Dina Rebecca , MONTGOMERY, Charles A. , PAYNE, Bobby Joe , PHILLIPS, Heidi , QIAN, Ni Nancy , RANGEL, Carolina , SHI, Zheng-Zheng , SPARKS, Mary Jean , STALA, Joy , VOGEL, Peter , SEVAUX, Tracy, Ellen, Willis , YE, Weilan , HORNER, Allison, Ann, Byers
IPC分类号： A01K67/027 , C12N15/85 , G01N33/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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3.发明公开
公开(公告)号：EP1988768A2
公开(公告)日：2008-11-12
申请号：EP07756828.5
申请日：2007-02-09
发明人： BOLLINGER, Kristi Rae , HORNER, Allison Anne Byers , COMBS, Katherin, E. , CULBERTSON, Ling Ling , CUNNINGHAM, Jaime-jo , DESAUVAGE, Frederic , EDWARDS, Joel , GIRGIS, Rosemary , GREEN, Leslie , MCLAIN, Dina Rebecca , MINZE, Laurie Jeanette , MONTGOMERY, Charles, A. , PAYNE, Bobby Joe , PHILLIPS, Heidi , SHI, Zheng-zheng , SPARKS, Mary Jean , STALA, Joy , TANG, Tracy Tzu-ling , TOWNSEND, Teresa Gail , VOGEL, Peter , SEVAUX, Tracy Ellen Willis
IPC分类号： A01K67/027 , A61K39/395 , C07K14/47 , C07K14/515 , C07K16/18 , G01N33/50
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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4.发明公开MEMORY AND LEARNING IMPAIRMENTS ASSOCIATED WITH DISRUPTION OF EPHRIN RECEPTOR A6 (EPHA6) GENE 审中-公开均与肝配蛋白受体A6（EphA6）基因的破坏连接存贮器和学习问题
公开(公告)号：EP2147019A1
公开(公告)日：2010-01-27
申请号：EP08746253.7
申请日：2008-04-18
IPC分类号： C07K14/715 , C12N15/85 , A01K67/027 , G01N33/50
CPC分类号： C12N15/8509 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A01K2267/0312 , C07K14/715 , G01N33/5088 , G01N2800/28 , G01N2800/2821 , G01N2800/2857
摘要： The present invention is based on investigation of the behaviour of mice in which EphA6 has been genetically inhibited.
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5.发明公开
公开(公告)号：EP1744620A2
公开(公告)日：2007-01-24
申请号：EP05736493.7
申请日：2005-04-12
发明人： BRENNAN, Jane , DESAUVAGE, Frederic , EDWARDS, Joel , FILVAROFF, Ellen , GREWAL, Iqbal , HUANG, Wenhu , IRVING, Bryan , JUNUTULA, Jagath Reddy , KIRCHHOFER, Daniel J. , MONTGOMERY, Chuck , PAYNE, Bobby Joe , PEALE JR., Franklin , PHILLIPS, Heidi , QIAN, Ni Nancy , SHI, Zheng-Zheng , SPARKS, Mary Jean , STALA, Joy , TANG, Tracy Tzu-Ling , VOGEL, Peter , YE, Weilan
IPC分类号： A01K67/027 , C12N15/85 , G01N33/50 , C12N5/10 , C12N15/12 , C12N15/15 , C12N15/24 , C12N15/52 , C12N15/55 , C12N15/57 , A61K49/00
CPC分类号： A01K67/0275 , A01K67/0278 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K49/0008 , C07K14/4703 , C07K14/705 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO256, PRO34421, PRO334, PRO770, PRO983, PRO1009, PRO1107, PRO1158, PRO1250, PRO1317, PRO4334, PRO4395, PRO49192, PRO9799, PRO21175, PRO19837, PRO21331, PRO23949, PRO697 or PRO1480 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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6.发明公开NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO 审中-公开新型GENUNTERBRECHUNGEN，相关组合物和方法
公开(公告)号：EP1781824A2
公开(公告)日：2007-05-09
申请号：EP05793413.5
申请日：2005-08-23
发明人： BRENNAN, Jane , DESAUVAGE, Frederic , EDWARDS, Joel , HUANG, Wenhu , MONTGOMERY, Chuck , PAYNE, Bobby Joe , SHI, Zheng-Zheng , SPARKS, Mary Jean , VOGEL, Peter , YE, Weilan
IPC分类号： C12Q1/68
CPC分类号： A01K67/0276 , A01K2217/05 , A01K2227/105 , A01K2267/02 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO196, PRO217, PRO231, PRO236, PRO245, PRO246, PRO258, PRO287, PRO328, PRO344, PRO357, PRO526, PRO724, PRO731, PRO732, PRO1003, PRO1104, PRO1151, PRO1244, PRO1298, PRO1313, PRO1570, PRO1886, PRO1891, PRO4409, PRO5725, PRO5994, PRO6097, PRO7425, PRO10102, PRO10282, PRO61709 or PRO779 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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7.发明公开
公开(公告)号：EP1694116A2
公开(公告)日：2006-08-30
申请号：EP04813966.1
申请日：2004-12-13
发明人： ANDERSON, Stephen , BRENNAN, Jane , DESAUVAGE, Frederic , DING, Zhiyong , EDWARDS, Joel , FIKES, Nelda , HUANG, Wenhu , OUYANG, Wenjun , RANGEL, Carolina , SANGHA, Mamta , SHI, Zheng-Zheng , SPARKS, Mary Jean , TRACKEY, Joseph , VETTER, Melissa , WANG, Ching-Yun , WOODINGS, Jessica
IPC分类号： A01K67/027
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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