公开(公告)号：EP1353953B1

公开(公告)日：2006-11-29

申请号：EP01937340.6

申请日：2001-05-11

申请人： Genetics Institute, LLC

发明人： DONALDSON, Debra, D. ,  UNGER, Michelle, J. ,  YOUNG, Deborah, A. ,  WHITTERS, Matthew, J. ,  LOWE, Leslie ,  COLLINS, Mary

IPC分类号： C07K14/715 ,  C12N15/12 ,  C12N15/66 ,  A61K38/17 ,  C07K16/28

CPC分类号： C07K14/715 ,  A61K38/00 ,  C07K2319/30

摘要： Polynucleotides encoding the MU-1 hematopoietin receptor superfamily chain and fragments thereof are disclosed. MU-1 proteins and methods for their production are also disclosed.

公开(公告)号：EP1173484B1

公开(公告)日：2011-07-06

申请号：EP00928591.7

申请日：2000-04-28

申请人： Genetics Institute, LLC ,  GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： WYNN, Thomas, A. ,  CHIARAMONTE, Monica, G. ,  COLLINS, Mary ,  DONALDSON, Debra ,  FITZ, Lori ,  NEBEN, Tamlyn ,  WHITTERS, Matthew, J. ,  WOOD, Clive

IPC分类号： C07K14/715 ,  C07K19/00 ,  A61K38/19 ,  A61K38/17 ,  A61K39/395 ,  A61K38/20 ,  A61P37/00 ,  A61P43/00

CPC分类号： C07K14/7155 ,  A61K38/00 ,  C07K2319/00 ,  Y02A50/423 ,  Y10S514/826

摘要： Methods are provided for treating or inhibiting the formation of tissue fibrosis using IL-13 antagonists, including without limitation soluble forms of the IL-13 receptor.

公开(公告)号：EP1432431A2

公开(公告)日：2004-06-30

申请号：EP02766319.4

申请日：2002-10-04

申请人： Genetics Institute, LLC

发明人： CARTER, Laura ,  WHITTERS, Matthew, J. ,  COLLINS, Mary ,  YOUNG, Deborah, A. ,  LARSEN, Glenn ,  DONALDSON, Debra, D. ,  LOWE, Leslie, D. ,  DUNUSSI, Kyri ,  MA, Margery ,  WITEK, JoAnn, S. ,  KASAIAN, Marion, T. ,  UNGAR, Michelle ,  CARRENO, Beatriz

IPC分类号： A61K38/00

CPC分类号： A61K31/519 ,  A61K31/42 ,  A61K31/453 ,  A61K38/1793 ,  A61K38/193 ,  A61K38/2013 ,  A61K38/2086 ,  A61K45/06 ,  C07K2319/30 ,  A61K2300/00

摘要： Methods and compositions for modulating interleukin-21 (IL-21)/IL-21 receptor (MU-1) activity using agonists or antagonists of IL-21 or IL-21 receptor ('IL-21R' or 'MU-1'), are disclosed. IL-21/IL-21R antagonists can be used to induce immune suppression in vivo, e.g., for treating or preventing immune cell-associated pathologies (e.g., pathologies associated with aberrant activity of one or more of mature T cells (mature CD8+, mature CD4+ T cells), mature NK cells, B cells, macrophages and megakaryocytes, including transplant rejection and autoimmune disorders). IL-21/IL-21R agonists can be used by themselves or in combination with an antigen, e.g., as an adjuvant (e.g., a vaccine adjuvant), to up-regulate an immune response in vivo, e.g., for example, for use in treating cancer and infectious disorders.

公开(公告)号：EP1432431B1

公开(公告)日：2017-05-10

申请号：EP02766319.4

申请日：2002-10-04

申请人： Genetics Institute LLC

发明人： CARTER, Laura ,  WHITTERS, Matthew, J. ,  COLLINS, Mary ,  YOUNG, Deborah, A. ,  LARSEN, Glenn ,  DONALDSON, Debra, D. ,  LOWE, Leslie, D. ,  DUNUSSI, Kyri ,  MA, Margery ,  WITEK, JoAnn, S. ,  KASAIAN, Marion, T. ,  UNGAR, Michelle ,  CARRENO, Beatriz

IPC分类号： A61K39/395 ,  A61P19/02

CPC分类号： A61K31/519 ,  A61K31/42 ,  A61K31/453 ,  A61K38/1793 ,  A61K38/193 ,  A61K38/2013 ,  A61K38/2086 ,  A61K45/06 ,  C07K2319/30 ,  A61K2300/00

公开(公告)号：EP1353953A2

公开(公告)日：2003-10-22

申请号：EP01937340.6

申请日：2001-05-11

申请人： Genetics Institute, LLC

发明人： DONALDSON, Debra, D. ,  UNGER, Michelle, J. ,  YOUNG, Deborah, A. ,  WHITTERS, Matthew, J. ,  LOWE, Leslie ,  COLLINS, Mary

IPC分类号： C07K14/715 ,  C12N15/12 ,  C12N15/66 ,  A61K38/17 ,  C07K16/28

CPC分类号： C07K14/715 ,  A61K38/00 ,  C07K2319/30

摘要： Polynucleotides encoding the MU-1 hematopoietin receptor superfamily chain and fragments thereof are disclosed. MU-1 proteins and methods for their production are also disclosed.

公开(公告)号：EP1141286B1

公开(公告)日：2006-10-18

申请号：EP99966166.3

申请日：1999-12-13

申请人： Genetics Institute, LLC ,  JOHNS HOPKINS UNIVERSITY

发明人： COLLINS, Mary ,  DONALDSON, Debra ,  FITZ, Lori ,  NEBEN, Tamlyn ,  WHITTERS, Matthew, J. ,  WOOD, Clive ,  WILLS-KARP, Marsha, Johns Hopkins University

IPC分类号： C12N15/12 ,  C07K14/715 ,  A61K38/00 ,  A61K39/00

CPC分类号： C07K14/7155 ,  A61K38/00 ,  A61K2039/505 ,  C07K2319/02

摘要： Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed. Methods of medical treatment using such molecules and antagonists of the IL-13/IL-13R interaction are also provided.