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公开(公告)号：EP2699262A2
公开(公告)日：2014-02-26
申请号：EP12718626.0
申请日：2012-04-20
申请人： Genmab A/S
发明人： NEIJSEEN, Joost, J. , MEESTERS, Joyce, I. , DE GOEIJ, Bart , LABRIJN, Aran, Frank , PARREN, Paul , SCHUURMAN, Janine
CPC分类号： C07K16/32 , A61K47/6829 , A61K2039/505 , C07K16/1063 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/41 , C07K2317/52 , C07K2317/526 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： Bispecific antibodies which comprise one antigen-binding region binding to an epitope of human epidermal growth factor receptor 2 (HER2) and one antigen-binding region binding to human CD3, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods for preparing and using the antibodies are also disclosed.
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公开(公告)号：EP2771364B1
公开(公告)日：2019-05-22
申请号：EP12783931.4
申请日：2012-10-26
申请人： Genmab A/S
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公开(公告)号：EP2771364A2
公开(公告)日：2014-09-03
申请号：EP12783931.4
申请日：2012-10-26
申请人： Genmab A/S
发明人： GRAMER, Michael , KUNDU, Amitava , VAN DEN BREMER, Ewald T.J. , VAN KAMPEN, Muriel , PRIEM, Patrick , LABRIJN, Aran Frank , MEESTERS, Joyce, I. , NEIJSSEN, Joost J. , SCHUURMAN, Janine , PARREN, Paul , VAN BERKEL, Patrick , VOS, Werner L. , GERRITSEN, Arnout
CPC分类号： C07K1/1133 , C07K16/2863 , C07K16/2887 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/732 , C07K2317/734 , C07K2317/90
摘要： The present invention relates to an in vitro method for production of heterodimeric proteins.
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