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公开(公告)号：EP2943507B1
公开(公告)日：2020-02-26
申请号：EP14700200.0
申请日：2014-01-09
申请人： Genmab A/S
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公开(公告)号：EP3091998A1
公开(公告)日：2016-11-16
申请号：EP15700081.1
申请日：2015-01-08
申请人： Genmab A/S
发明人： BRINK, Edward Norbert Van Den , NEIJSSEN, Joost J. , LABRIJN, Aran Frank , MEESTERS, Joyce , SCHUURMAN, Janine , ALTINTAS, Isil , PARREN, Paul , RADEMAKER, Rik
CPC分类号： C07K16/2809 , A61K2039/505 , C07K16/1063 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/32 , C07K16/4241 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/74 , C07K2317/75 , C07K2317/90 , C07K2317/92 , G01N33/6872 , G01N2333/7051
摘要： The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：EP3016681B1
公开(公告)日：2019-12-18
申请号：EP14737200.7
申请日：2014-07-04
申请人： Genmab A/S
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公开(公告)号：EP2771364B1
公开(公告)日：2019-05-22
申请号：EP12783931.4
申请日：2012-10-26
申请人： Genmab A/S
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公开(公告)号：EP3693385A1
公开(公告)日：2020-08-12
申请号：EP19217231.0
申请日：2014-07-04
申请人： Genmab A/S
发明人： VAN DEN BRINK, Edward , NEIJSSEN, Joost J. , LABRIJN, Aran Frank , MEESTERS, Joyce , SCHUURMAN, Janine , PARREN, Paul
摘要： The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：EP2943507A1
公开(公告)日：2015-11-18
申请号：EP14700200.0
申请日：2014-01-09
申请人： Genmab A/S
发明人： LABRIJN, Aran Frank , MEESTERS, Joyce , NEIJSSEN, Joost J. , VAN DEN BRINK, Edward Norbert , SCHUURMAN, Janine , PARREN, Paul
摘要： The present invention relates to dimeric proteins comprising amino acids at three different positions which are different from those present in a human IgG1. Six of said dimeric proteins are capable of forming a hexameric structure in solution.
摘要翻译： 本发明涉及包含不同于人IgG1中存在的三个不同位置的氨基酸的二聚体蛋白质。 所述二聚蛋白中的六个能够在溶液中形成六聚体结构。
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公开(公告)号：EP2389392A1
公开(公告)日：2011-11-30
申请号：EP10701360.9
申请日：2010-01-26
申请人： Genmab A/S
发明人： PARREN, Paul , NEIJSSEN, Joost J. , LABRIJN, Aran Frank , SCHUURMAN, Janine , VINK, Tom , VAN DE WINKEL, Jan , LOVERIX, Stefan , LASTERS, Ignace
IPC分类号： C07K16/00 , C07K16/28 , C07K16/32 , A61K39/395 , A61P35/00
CPC分类号： C07K16/00 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/32 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/622 , C07K2317/626
摘要： The invention relates to a method for producing a mixture comprising two or more different antibodies in a single recombinant host cell. In one embodiment, a mixture of different monovalent antibodies is produced. In another embodiment, a mixture of monovalent and bivalent antibodies is produced. The invention also relates to mixtures of antibodies obtainable by the method of the invention and to light chain sequences that are particularly useful in the method of the invention.
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公开(公告)号：EP4249515A3
公开(公告)日：2023-11-15
申请号：EP23174159.6
申请日：2015-01-08
申请人： Genmab A/S
发明人： BRINK, Edward Norbert Van Den , NEIJSSEN, Joost J. , LABRIJN, Aran Frank , MEESTERS, Joyce , SCHUURMAN, Janine , ALTINTAS, Isil , PARREN, Paul , RADEMAKER, Rik
摘要： The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：EP4249515A2
公开(公告)日：2023-09-27
申请号：EP23174159.6
申请日：2015-01-08
申请人： Genmab A/S
发明人： BRINK, Edward Norbert Van Den , NEIJSSEN, Joost J. , LABRIJN, Aran Frank , MEESTERS, Joyce , SCHUURMAN, Janine , ALTINTAS, Isil , PARREN, Paul , RADEMAKER, Rik
IPC分类号： C07K16/46
摘要： The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：EP3016681A1
公开(公告)日：2016-05-11
申请号：EP14737200.7
申请日：2014-07-04
申请人： Genmab A/S
发明人： VAN DEN BRINK, Edward , NEIJSSEN, Joost J. , LABRIJN, Aran Frank , MEESTERS, Joyce , SCHUURMAN, Janine , PARREN, Paul
摘要： The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
摘要翻译： 本发明涉及结合CD3的人源化或嵌合抗体。 本发明还涉及双特异性抗体，组合物，药物组合物，所述抗体在治疗疾病中的用途以及治疗方法。
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