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公开(公告)号：EP3674320A3
公开(公告)日：2020-08-12
申请号：EP19174712.0
申请日：2012-10-26
申请人： Genmab A/S
发明人： GRAMER, Michael , KUNDU, Amitava , VAN DEN BREMER, Ewald T J , VAN KAMPEN, Muriel , PRIEM, Patrick , MEESTERS, Joyce I , NEIJSSEN, Joost J , SCHUURMAN, Janine , PARREN, Paul , VAN BERKEL, Patrick , VOS, Werner L , LABRIJN, Aran F
摘要： The present invention relates to an in vitro method for production of heterodimeric proteins.
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公开(公告)号：EP2771364A2
公开(公告)日：2014-09-03
申请号：EP12783931.4
申请日：2012-10-26
申请人： Genmab A/S
发明人： GRAMER, Michael , KUNDU, Amitava , VAN DEN BREMER, Ewald T.J. , VAN KAMPEN, Muriel , PRIEM, Patrick , LABRIJN, Aran Frank , MEESTERS, Joyce, I. , NEIJSSEN, Joost J. , SCHUURMAN, Janine , PARREN, Paul , VAN BERKEL, Patrick , VOS, Werner L. , GERRITSEN, Arnout
CPC分类号： C07K1/1133 , C07K16/2863 , C07K16/2887 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/732 , C07K2317/734 , C07K2317/90
摘要： The present invention relates to an in vitro method for production of heterodimeric proteins.
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公开(公告)号：EP2699260A1
公开(公告)日：2014-02-26
申请号：EP12715407.8
申请日：2012-04-20
申请人： Genmab A/S
发明人： DE GOEIJ, Bart , VAN BERKEL, Patrick , STRUMANE, Kristin , LABRIJN, Aran Frank , NEIJSSEN, Joost J. , MEESTERS, Joyce I. , PARREN, Paul , SCHUURMAN, Janine
CPC分类号： C07K16/1063 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/94
摘要： Bispecific antibodies which comprise antigen-binding regions binding to two different epitopes of human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods of preparing and using the antibodies are also disclosed.
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4.发明授权
公开(公告)号：EP2729496B8
公开(公告)日：2017-10-18
申请号：EP12731507.5
申请日：2012-07-06
申请人： Genmab A/S
IPC分类号： C07K16/00
CPC分类号： C07K16/18 , C07K16/00 , C07K2317/51 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/734 , G01N33/5014 , G01N33/6854
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5.发明公开TRANSGENIC ANIMALS PRODUCING MONOVALENT HUMAN ANTIBODIES AND ANTIBODIES OBTAINABLE FROM THESE ANIMALS 审中-公开MONO VALENTE人体产生抗体的转基因动物和这些动物可分离的抗体
公开(公告)号：EP2167669A2
公开(公告)日：2010-03-31
申请号：EP08748826.8
申请日：2008-05-30
申请人： Genmab A/S
发明人： SCHUURMAN, Janine , VINK, Tom , VAN DE WINKEL, Jan , LABRIJN, Aran Frank , PARREN, Paul , BLEEKER, Willem Karel , BEURSKENS, Frank , VAN BERKEL, Patrick
CPC分类号： C07K16/2887 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/283 , C07K16/2863 , C07K2317/21 , C07K2317/55 , C07K2317/732 , C07K2317/77 , C07K2317/90 , C12N15/8509 , C12N2740/16011
摘要： The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.
摘要翻译： 本发明涉及一种新颖的非人类转基因动物，其在抗原刺激能产生单价抗体结合选定的抗原，修饰的重链转基因方法用于产生非人转基因动物，用于免疫非人类转基因方法 动物以及单价抗体可获得的寻求免疫方法。
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6.发明公开
公开(公告)号：EP1910836A2
公开(公告)日：2008-04-16
申请号：EP06753363.8
申请日：2006-07-21
申请人： Genmab A/S
IPC分类号： G01N33/566 , A61K39/395
CPC分类号： C07K16/2812 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/732 , C07K2317/76 , G01N33/566 , G01N2333/70535
摘要： The invention relates to a method of characterizing an antibody, which method is suitable as a potency assay for batch release of a pharmaceutical composition comprising an antibody, specifically for use when applying for marketing authorization for said pharmaceutical composition. The assay provided is a method for determining the potency of a drug product comprising an FcR binding peptide, wherein at least one mechanism of action of the FcR binding peptide of the drug product is mediated through the binding of the FcR binding peptide of the drug product to a Fc receptor, wherein said method comprises determining the binding of the FcR binding peptide of the drug product to an Fc receptor.
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公开(公告)号：EP2771364B1
公开(公告)日：2019-05-22
申请号：EP12783931.4
申请日：2012-10-26
申请人： Genmab A/S
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公开(公告)号：EP1973576B1
公开(公告)日：2019-05-15
申请号：EP06818129.6
申请日：2006-11-28
申请人： Genmab A/S
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9.发明公开METHOD FOR EXTENDING THE HALF-LIFE OF EXOGENOUS OR ENDOGENOUS SOLUBLE MOLECULES 审中-公开程序续期的半衰期内生还是外生可溶性分子中的
公开(公告)号：EP2155790A1
公开(公告)日：2010-02-24
申请号：EP08748827.6
申请日：2008-05-30
申请人： Genmab A/S
发明人： SCHUURMAN, Janine , VINK, Tom , VAN DE WINKEL, Jan , LABRIJN, Aran Frank , PARREN, Paul , BEURSKENS, Frank , BLEEKER, Willem Karel , VAN BERKEL, Patrick
IPC分类号： C07K16/28
CPC分类号： C07K16/283 , C07K16/2812 , C07K16/2863 , C07K16/2887 , C07K2317/732
摘要： The present invention relates to methods for extending the in vivo half-life of an exogenous soluble therapeutic molecule administered to a subject, by administering to said subject the exogenous soluble molecule and a monovalent antibody that binds to the exogenous soluble molecule, as well as method for treating a disease or disorder associated with an insufficient level of an endogenous soluble molecule in a subject, by administering to said subject a monovalent antibody that binds to the endogenous soluble molecule.
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10.发明公开
公开(公告)号：EP1973576A1
公开(公告)日：2008-10-01
申请号：EP06818129.6
申请日：2006-11-28
申请人： Genmab A/S
发明人： PARREN, Paul , SCHUURMAN, Janine , VINK, Tom , BLEEKER, Willem, Karel , VAN DE WINKEL, Jan, G.J. , VAN BERKEL, Patrick , BEURSKENS, Frank
CPC分类号： C07K16/2863 , C07K16/2812 , C07K16/283 , C07K16/2887 , C07K2317/21 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77
摘要： The present invention provides monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies, pharmaceutical compositions comprising such antibodies, and uses of the monovalent antibodies.
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