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公开(公告)号：EP3358011A1
公开(公告)日：2018-08-08
申请号：EP18160112.1
申请日：2012-04-03
发明人： TAMAI, Katsuto , YAMAZAKI, Takehiko , KANEZAKI, Tsutomu , SAKURAI, Shigeru , NOGUCHI, Yukiko , ENDO, Mayumi , HAMABUCHI, Natsumi , NAITO, Kana
IPC分类号： C12N15/09 , A61K31/711 , A61K31/713 , A61K35/12 , A61K35/28 , A61K35/76 , A61K38/00 , A61K48/00 , A61P1/00 , A61P1/04 , A61P9/00 , A61P9/10 , A61P17/00 , A61P19/00 , A61P21/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
摘要： The present invention concerns therapeutic agents that, in association with stimulation of PDGFRα-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. In particular, fragments of High mobility Group Box 1 (HMGB1 or amphoterin) which stimulate PDGFRalpha-positive cells and promote their mobilization into blood and accumulation in a damaged tissue. Peptide fragments of HMGB1 were identified with migration-promoting activity on PDGFR-alpha-positive bone marrow mesenchymal stem cell line (MSC-1) and skin fibroblasts.
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公开(公告)号：EP2703487B1
公开(公告)日：2018-06-27
申请号：EP12777041.0
申请日：2012-04-03
发明人： TAMAI, Katsuto , YAMAZAKI, Takehiko , KANEZAKI, Tsutomu , SAKURAI, Shigeru , NOGUCHI, Yukiko , ENDO, Mayumi , HAMABUCHI, Natsumi , NAITO, Kana
IPC分类号： C12N15/09 , A61K31/711 , A61K31/713 , A61K35/12 , A61K35/28 , A61K35/76 , A61K38/00 , A61K48/00 , A61P1/00 , A61P1/04 , A61P9/00 , A61P9/10 , A61P17/00 , A61P19/00 , A61P21/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
CPC分类号： C07K14/4705 , A61K38/17 , C07K14/4702
摘要： (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFR±-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. (Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFR±-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFR±-positive cells.
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公开(公告)号：EP2703487A1
公开(公告)日：2014-03-05
申请号：EP12777041.0
申请日：2012-04-03
发明人： TAMAI, Katsuto , YAMAZAKI, Takehiko , KANEZAKI, Tsutomu , SAKURAI, Shigeru , NOGUCHI, Yukiko , ENDO, Mayumi , HAMABUCHI, Natsumi , NAITO, Kana
IPC分类号： C12N15/09 , A61K31/711 , A61K31/713 , A61K35/12 , A61K35/28 , A61K35/76 , A61K38/00 , A61K48/00 , A61P1/00 , A61P1/04 , A61P9/00 , A61P9/10 , A61P17/00 , A61P19/00 , A61P21/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
CPC分类号： C07K14/4705 , A61K38/17 , C07K14/4702
摘要： (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFRα-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body.
(Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFRα-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFRα-positive cells.摘要翻译： （目的）本发明的目的在于提供与PDGFRα阳性细胞例如骨髓间充质干细胞的刺激相关的治疗剂促进它们动员入血并积聚在受损组织中，并诱导组织再生 一个活体。 （溶液的手段）合成多种肽，评价各肽的迁移促进活性。 结果，本发明人成功鉴定了对PDGFRα阳性骨髓间充质干细胞系（MSC-1）具有迁移促进活性的多种肽。 此外，本发明人确认，所鉴定的肽还对PDGFRα阳性细胞即皮肤成纤维细胞具有迁移促进活性。
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公开(公告)号：EP3358011B1
公开(公告)日：2020-03-04
申请号：EP18160112.1
申请日：2012-04-03
申请人： StemRIM Inc. , OSAKA UNIVERSITY
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