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公开(公告)号:EP4279074A1
公开(公告)日:2023-11-22
申请号:EP22174346.1
申请日:2022-05-19
申请人: Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin , Georg-August-Universität Göttingen
发明人: TIETZE, Lutz Friedjahn , MOTHUKU, Shyam Sundar , ZEISBERG, Michael , HASENFUSS, Gerd , NYAMSUREN, Gunsmaa , VOSS, Edgar
IPC分类号: A61K31/5025 , A61P1/00 , A61P9/00 , A61P11/00 , A61P13/12
摘要: The present invention relates to an azolo compound of Formula I
for use in the treatment of fibrosis, wherein the azolo compounds normalizes collagen I mRNA-levels of TGFβ-activated fibroblasts and reverses collagen production to the normal levels that are seen in fibroblasts that are not stimulated.-
公开(公告)号:EP4404931A1
公开(公告)日:2024-07-31
申请号:EP23735593.8
申请日:2023-05-19
申请人: Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin , Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts
发明人: TIETZE, Lutz Friedjahn , VOSS, Edgar , MOTHUKU, Shyam Sundar , ZEISBERG, Michael , HASENFUSS, Gerd , NYAMSUREN, Gunsmaa
IPC分类号: A61K31/5025 , A61P1/00 , A61P9/00 , A61P11/00 , A61P13/12
CPC分类号: A61K31/5025 , A61P9/00 , A61P1/00 , A61P11/00 , A61P13/12
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公开(公告)号:EP4038360A1
公开(公告)日:2022-08-10
申请号:EP20785732.7
申请日:2020-09-30
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