专利检索 ap:("Gilead Sciences, Inc.") AND inv:"GRIGGS, Nolan" 第 1 页

1.

发明公开
PROCESSES FOR PREPARING ASK1 INHIBITORS 审中-公开

公开(公告)号：EP4276095A2

公开(公告)日：2023-11-15

申请号：EP23181912.9

申请日：2015-12-22

申请人： Gilead Sciences, Inc.

发明人： BROWN, Brandon Heath , CHAN, Brenda J. Burke , CHIU, Anna , GRIGGS, Nolan , HEUMANN, Lars V. , LATHROP, Stephen P. , REYNOLDS, Troy Evan , SARMA, Keshab , SILER, David Allen , THOMPSON, Andrew S. , WANG, Tao , NOTTE, Gregory

IPC分类号： C07D233/56

摘要： The present disclosure provides processes for the preparation of a compound of formula:

which exhibits apoptosis signal-regulating kinase ("ASK1") inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.

2.

发明公开
PROCESSES FOR PREPARING ASK1 INHIBITORS 审中-公开

公开(公告)号：EP4276095A3

公开(公告)日：2024-01-17

申请号：EP23181912.9

申请日：2015-12-22

申请人： Gilead Sciences, Inc.

发明人： BROWN, Brandon Heath , CHAN, Brenda J. Burke , CHIU, Anna , GRIGGS, Nolan , HEUMANN, Lars V. , LATHROP, Stephen P. , REYNOLDS, Troy Evan , SARMA, Keshab , SILER, David Allen , THOMPSON, Andrew S. , WANG, Tao , NOTTE, Gregory

IPC分类号： C07D401/14 , C07D233/56

摘要： The present disclosure provides processes for the preparation of a compound of formula:

which exhibits apoptosis signal-regulating kinase ("ASK1") inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.

3.

发明授权
SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS 有权

公开(公告)号：EP3527573B1

公开(公告)日：2020-08-12

申请号：EP19152851.2

申请日：2015-06-16

申请人： Gilead Sciences, Inc.

发明人： CHIU, Anna , ENQUIST, John , GRIGGS, Nolan , HALE, Christopher , IKEMOTO, Norihiro , KEATON, Katie, Ann , KRAFT, Matt , LAZERWITH, Scott, E. , LEEMAN, Michel , PENG, Zhihui , SCHRIER, Kate , TRINIDAD, Jonathan , HERPT, Jochem, Van , WALTMAN, Andrew, W.

IPC分类号： C07D498/22 , C07C213/02 , C07C213/10 , C07C235/80 , C07C237/16 , C07C269/06 , C07D213/82 , C07D309/40 , C07D319/06

4.

发明公开
METHODS OF PREPARING 1'-CYANO NUCLEOSIDES 审中-公开

公开(公告)号：EP4118085A2

公开(公告)日：2023-01-18

申请号：EP21716888.9

申请日：2021-03-11

申请人： GILEAD SCIENCES, INC.

发明人： BADALOV, Pavel R. , BREMNER, Stacy , CHIN, Matthew R. , GAO, Detian , GRIGGS, Nolan , HEUMANN, Lars V. , LAI, Chiajen , MILBURN, Robert R. , MOHAN, Sankar , NEVILLE, Sean T. , SHI, Bing , STEVENS, Andrew C. , UHLIG, Nicholas A.J. , VIEIRA, Tiago , WENDERSKI, Todd A.

IPC分类号： C07D487/04 , C07H1/00 , C07H7/06

5.

发明公开
SOLID FORMS OF FXR AGONISTS 审中-公开

公开(公告)号：EP3927683A1

公开(公告)日：2021-12-29

申请号：EP20711438.0

申请日：2020-02-14

申请人： GILEAD SCIENCES, INC.

发明人： DALTON, Derek, M. , FUNG, Peter, C. , GRIGGS, Nolan , HEMENWAY, Jeffrey, N. , LAPINA, Olga, V. , LOGAN, Matthew, M. , NEVILLE, Sean, T. , REYNOLDS, Bryan, J. , SHIH, Hui-Wen , WAGNER, Anna, M.

IPC分类号： C07C215/10 , C07C309/30 , C07D413/14 , A61K31/4427 , A61P1/16 , A61P3/10 , A61P35/00

6.

发明授权
SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS 有权

公开(公告)号：EP3157933B1

公开(公告)日：2019-02-27

申请号：EP15739049.3

申请日：2015-06-16

申请人： Gilead Sciences, Inc.

发明人： CHIU, Anna , ENQUIST, John , GRIGGS, Nolan , HALE, Christopher , IKEMOTO, Norihiro , KEATON, Katie, Ann , KRAFT, Matt , LAZERWITH, Scott, E. , LEEMAN, Michel , PENG, Zhihui , SCHRIER, Kate , TRINIDAD, Jonathan , HERPT, Jochem, Van , WALTMAN, Andrew, W.

IPC分类号： C07D498/22 , C07C213/02 , C07C213/10 , C07C235/80 , C07C237/16 , C07C269/06 , C07D213/82 , C07D309/40 , C07D319/06

7.

发明公开
SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS 审中-公开

公开(公告)号：EP3783001A1

公开(公告)日：2021-02-24

申请号：EP20185449.4

申请日：2015-06-16

申请人： Gilead Sciences, Inc.

发明人： CHIU, Anna , ENQUIST, John , GRIGGS, Nolan , HALE, Christopher , IKEMOTO, Norihiro , KEATON, Katie, Ann , KRAFT, Matt , LAZERWITH, Scott, E. , LEEMAN, Michel , PENG, Zhihui , SCHRIER, Kate , TRINIDAD, Jonathan , HERPT, Jochem, Van , WALTMAN, Andrew, W.

IPC分类号： C07D498/22 , C07C213/02 , C07C213/10 , C07C235/80 , C07C237/16 , C07C269/06 , C07D213/82 , C07D309/40 , C07D319/06

摘要： A method of making compounds of Formula (I) is disclosed.

8.

发明授权
PROCESSES FOR PREPARING ASK1 INHIBITORS 有权

公开(公告)号：EP3237404B1

公开(公告)日：2020-11-11

申请号：EP15830935.1

申请日：2015-12-22

申请人： Gilead Sciences, Inc.

发明人： BROWN, Brandon Heath , CHAN, Brenda J. Burke , CHIU, Anna , GRIGGS, Nolan , HEUMANN, Lars V. , LATHROP, Stephen P. , REYNOLDS, Troy Evan , SARMA, Keshab , SILER, David Allen , THOMPSON, Andrew S. , WANG, Tao , NOTTE, Gregory

IPC分类号： C07D401/14 , C07D233/56

9.

发明公开
PROCESSES FOR PREPARING ASK1 INHIBITORS 审中-公开

公开(公告)号：EP3693366A1

公开(公告)日：2020-08-12

申请号：EP20167420.7

申请日：2015-12-22

申请人： Gilead Sciences, Inc.

发明人： BROWN, Brandon Heath , CHAN, Brenda J. Burke , CHIU, Anna , GRIGGS, Nolan , HEUMANN, Lars V. , LATHROP, Stephan P. , REYNOLDS, Troy Evan , SARMA, Keshab , SILER, David Allen , THOMSON, Andrew S. , WANG, Tao , NOTTE, Gregory

IPC分类号： C07D401/14 , C07D233/56

摘要： The present disclosure provides processes for the preparation of a compound of formula:

which exhibits apoptosis signal-regulating kinase ("ASK1") inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.

10.

发明公开
SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS 审中-公开

公开(公告)号：EP3527573A1

公开(公告)日：2019-08-21

申请号：EP19152851.2

申请日：2015-06-16

申请人： Gilead Sciences, Inc.

发明人： CHIU, Anna , ENQUIST, John , GRIGGS, Nolan , HALE, Christopher , IKEMOTO, Norihiro , KEATON, Katie, Ann , KRAFT, Matt , LAZERWITH, Scott, E. , LEEMAN, Michel , PENG, Zhihui , SCHRIER, Kate , TRINIDAD, Jonathan , HERPT, Jochem, Van , WALTMAN, Andrew, W.

IPC分类号： C07D498/22 , C07C213/02 , C07C213/10 , C07C235/80 , C07C237/16 , C07C269/06 , C07D213/82 , C07D309/40 , C07D319/06

摘要： Methods of making compounds of Formula (I) are disclosed.