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公开(公告)号：EP3085696B1
公开(公告)日：2020-03-04
申请号：EP16169386.6
申请日：2012-06-29
发明人： Corkey, Britton Kenneth , Elzein, Elfatih , Jiang, Robert H , Kalla, Rao V , Koltun, Dmitry , Li, Xiaofen , Martinez, Ruben , Parkhill, Eric Q , Perry, Thao , Zablocki, Jeff , Venkataramani, Chandrasekar , Graupe, Michael , Guerrero, Juan A.
IPC分类号： C07D267/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D498/04 , A61K31/553 , A61P9/10
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公开(公告)号：EP3085694B1
公开(公告)日：2020-03-25
申请号：EP16169306.4
申请日：2012-06-29
发明人： Corkey, Britton Kenneth , Elzein, Elfatih , Jiang, Robert H , Kalla, Rao V , Koltun, Dmitry , Li, Xiaofen , Martinez, Ruben , Parkhill, Eric Q , Perry, Thao , Zablocki, Jeff , Venkataramani, Chandrasekar , Graupe, Michael , Guerrero, Juan A
IPC分类号： C07D243/24 , C07D267/14 , C07D291/08 , C07D403/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D419/06 , C07D471/04 , C07D487/04 , C07D498/04 , A61K31/5513 , A61K31/553 , A61K31/554
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公开(公告)号：EP3275870B1
公开(公告)日：2020-02-05
申请号：EP17187226.0
申请日：2012-05-08
发明人： Corkey, Britton Kenneth , Elzein, Elfatih , Jiang, Robert H , Kalla, Rao V , Kobayashi, Tetsuya , Koltun, Dmitry , Li, Xiaofen , Martinez, Ruben , Notte, Gregory , Parkhill, Eric Q , Perry, Thao , Zablocki, Jeff , Venkataramani, Chandrasekar , Graupe, Michael , Guerrero, Juan
IPC分类号： C07D237/32 , C07D253/08 , C07D265/22 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D403/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/14 , C07D217/24 , C07D239/88 , C07D239/90 , C07D405/12
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公开(公告)号：EP3275870A1
公开(公告)日：2018-01-31
申请号：EP17187226.0
申请日：2012-05-08
发明人： Corkey, Britton Kenneth , Elzein, Elfatih , Jiang, Robert H , Kalla, Rao V , Kobayashi, Tetsuya , Koltun, Dmitry , Li, Xiaofen , Martinez, Ruben , Notte, Gregory , Parkhill, Eric Q , Perry, Thao , Zablocki, Jeff , Venkataramani, Chandrasekar , Graupe, Michael , Guerrero, Juan
IPC分类号： C07D237/32
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I:
wherein Q, R 1 , X 1 , X 2 , Y and R 2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.摘要翻译： 本公开涉及作为钠通道抑制剂的化合物及其在治疗各种疾病状态（包括心血管疾病和糖尿病）中的用途。 在具体的实施方案中，所述化合物的结构由式I给出：其中Q，R 1，X 1，X 2，Y和R 2如本文所述，制备和使用所述化合物的方法和含有所述化合物的药物组合物。
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公开(公告)号：EP3085696A1
公开(公告)日：2016-10-26
申请号：EP16169386.6
申请日：2012-06-29
发明人： Corkey, Britton Kenneth , Elzein, Elfatih , Jiang, Robert H , Kalla, Rao V , Koltun, Dmitry , Li, Xiaofen , Martinez, Ruben , Parkhill, Eric Q , Perry, Thao , Zablocki, Jeff , Venkataramani, Chandrasekar , Graupe, Michael , Guerrero, Juan A.
IPC分类号： C07D267/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D498/04 , A61K31/553 , A61P9/10
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes.
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公开(公告)号：EP3085694A1
公开(公告)日：2016-10-26
申请号：EP16169306.4
申请日：2012-06-29
发明人： Corkey, Britton Kenneth , Elzein, Elfatih , Jiang, Robert H , Kalla, Rao V , Koltun, Dmitry , Li, Xiaofen , Martinez, Ruben , Parkhill, Eric Q , Perry, Thao , Zablocki, Jeff , Venkataramani, Chandrasekar , Graupe, Michael , Guerrero, Juan A
IPC分类号： C07D243/24 , C07D267/14 , C07D291/08 , C07D403/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D419/06 , C07D471/04 , C07D487/04 , C07D498/04 , A61K31/5513 , A61K31/553 , A61K31/554
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes.
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