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1.发明公开Process for preparing an A2A-adenosine receptor agonist and its polymorphs 审中-公开Verfahren zur Herstellung eines A2A-Adenosin-Rezeptor-Agonisten und seiner Polymorphe
公开(公告)号：EP2581381A2
公开(公告)日：2013-04-17
申请号：EP12008201.1
申请日：2007-02-02
发明人： Zablocki, Jeff , Elzein, Elfatih
IPC分类号： C07H19/167
CPC分类号： C07H19/16 , C07H19/167
摘要： Disclosed is a synthesis suitable for large scale manufacture of an A2A- adenosine receptor agonist, and also relates to polymorphs of that compound, and to methods of isolating a specific polymorph.
摘要翻译： 本发明涉及一种适用于大规模生产A2A-腺苷受体激动剂的合成物，还涉及该化合物的多晶型物，以及分离特定多晶型物的方法。
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公开(公告)号：EP3088395A1
公开(公告)日：2016-11-02
申请号：EP16169333.8
申请日：2012-06-29
发明人： Corkey, Britton Kenneth , Elzein, Elfatih , Jiang, Robert H. , Kalla, Rao V. , Koltun, Dmitry , LI, Xiaofen , Martinez, Ruben , Parkhill, Eric Q. , Perry, Thao , Zablocki, Jeff , Venkataramani,Chandrasekar , Graupe, Micahel , Guerrero, Juan A.
IPC分类号： C07D243/24 , C07D267/14 , C07D291/08 , C07D403/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D419/06 , C07D471/04 , C07D487/04 , C07D498/04 , A61K31/5513 , A61K31/553 , A61K31/554
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes.
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公开(公告)号：EP3085696B1
公开(公告)日：2020-03-04
申请号：EP16169386.6
申请日：2012-06-29
发明人： Corkey, Britton Kenneth , Elzein, Elfatih , Jiang, Robert H , Kalla, Rao V , Koltun, Dmitry , Li, Xiaofen , Martinez, Ruben , Parkhill, Eric Q , Perry, Thao , Zablocki, Jeff , Venkataramani, Chandrasekar , Graupe, Michael , Guerrero, Juan A.
IPC分类号： C07D267/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D498/04 , A61K31/553 , A61P9/10
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公开(公告)号：EP3101013A1
公开(公告)日：2016-12-07
申请号：EP16169314.8
申请日：2012-06-29
发明人： Corkey, Britton Kenneth , Elzein, Elfatih , Jiang, Robert H. , Kalla, Rao V. , Koltun, Dmitry , Li, Xiaofen , Martinez, Ruben , Parkhill, Eric Q. , Perry, Thao , Zablocki, Jeff , Venkataramani, Chandrasekar , Graupe, Michael , Guerrero, Juan A.
IPC分类号： C07D267/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D498/04 , A61K31/553 , A61P9/10
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes.
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公开(公告)号：EP3085694B1
公开(公告)日：2020-03-25
申请号：EP16169306.4
申请日：2012-06-29
发明人： Corkey, Britton Kenneth , Elzein, Elfatih , Jiang, Robert H , Kalla, Rao V , Koltun, Dmitry , Li, Xiaofen , Martinez, Ruben , Parkhill, Eric Q , Perry, Thao , Zablocki, Jeff , Venkataramani, Chandrasekar , Graupe, Michael , Guerrero, Juan A
IPC分类号： C07D243/24 , C07D267/14 , C07D291/08 , C07D403/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D419/06 , C07D471/04 , C07D487/04 , C07D498/04 , A61K31/5513 , A61K31/553 , A61K31/554
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公开(公告)号：EP3275870B1
公开(公告)日：2020-02-05
申请号：EP17187226.0
申请日：2012-05-08
发明人： Corkey, Britton Kenneth , Elzein, Elfatih , Jiang, Robert H , Kalla, Rao V , Kobayashi, Tetsuya , Koltun, Dmitry , Li, Xiaofen , Martinez, Ruben , Notte, Gregory , Parkhill, Eric Q , Perry, Thao , Zablocki, Jeff , Venkataramani, Chandrasekar , Graupe, Michael , Guerrero, Juan
IPC分类号： C07D237/32 , C07D253/08 , C07D265/22 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D403/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/14 , C07D217/24 , C07D239/88 , C07D239/90 , C07D405/12
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公开(公告)号：EP3275870A1
公开(公告)日：2018-01-31
申请号：EP17187226.0
申请日：2012-05-08
发明人： Corkey, Britton Kenneth , Elzein, Elfatih , Jiang, Robert H , Kalla, Rao V , Kobayashi, Tetsuya , Koltun, Dmitry , Li, Xiaofen , Martinez, Ruben , Notte, Gregory , Parkhill, Eric Q , Perry, Thao , Zablocki, Jeff , Venkataramani, Chandrasekar , Graupe, Michael , Guerrero, Juan
IPC分类号： C07D237/32
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I:
wherein Q, R 1 , X 1 , X 2 , Y and R 2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.摘要翻译： 本公开涉及作为钠通道抑制剂的化合物及其在治疗各种疾病状态（包括心血管疾病和糖尿病）中的用途。 在具体的实施方案中，所述化合物的结构由式I给出：其中Q，R 1，X 1，X 2，Y和R 2如本文所述，制备和使用所述化合物的方法和含有所述化合物的药物组合物。
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公开(公告)号：EP3085696A1
公开(公告)日：2016-10-26
申请号：EP16169386.6
申请日：2012-06-29
发明人： Corkey, Britton Kenneth , Elzein, Elfatih , Jiang, Robert H , Kalla, Rao V , Koltun, Dmitry , Li, Xiaofen , Martinez, Ruben , Parkhill, Eric Q , Perry, Thao , Zablocki, Jeff , Venkataramani, Chandrasekar , Graupe, Michael , Guerrero, Juan A.
IPC分类号： C07D267/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D498/04 , A61K31/553 , A61P9/10
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes.
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公开(公告)号：EP3085694A1
公开(公告)日：2016-10-26
申请号：EP16169306.4
申请日：2012-06-29
发明人： Corkey, Britton Kenneth , Elzein, Elfatih , Jiang, Robert H , Kalla, Rao V , Koltun, Dmitry , Li, Xiaofen , Martinez, Ruben , Parkhill, Eric Q , Perry, Thao , Zablocki, Jeff , Venkataramani, Chandrasekar , Graupe, Michael , Guerrero, Juan A
IPC分类号： C07D243/24 , C07D267/14 , C07D291/08 , C07D403/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D419/06 , C07D471/04 , C07D487/04 , C07D498/04 , A61K31/5513 , A61K31/553 , A61K31/554
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes.
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公开(公告)号：EP3101013B1
公开(公告)日：2020-10-21
申请号：EP16169314.8
申请日：2012-06-29
发明人： Corkey, Britton Kenneth , Elzein, Elfatih , Jiang, Robert H. , Kalla, Rao V. , Koltun, Dmitry , Li, Xiaofen , Martinez, Ruben , Parkhill, Eric Q. , Perry, Thao , Zablocki, Jeff , Venkataramani, Chandrasekar , Graupe, Michael , Guerrero, Juan A.
IPC分类号： C07D267/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D498/04 , A61K31/553 , A61P9/10
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