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1.发明公开PHENYL-PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORICOID RECEPTOR LIGANDS 有权苯基吡唑衍生物作为非甾体类糖皮质激素受体配体
公开(公告)号：EP2029549A2
公开(公告)日：2009-03-04
申请号：EP07765362.4
申请日：2007-06-11
申请人： Glaxo Group Limited
发明人： BARNETT, Heather, Anne , CAMPBELL, Ian, Baxter , COE, Diane, Mary , COOPER, Anthony, William, James , INGLIS, Graham, George, Adam , JONES, Haydn, Terence , KEELING, Steven, Philip , MACDONALD, Simon, John, Fawcett , MCLAY, Iain, McFarlane , SKONE, Philip, Alan , WEINGARTEN, Gordon, Gad , WOOLVEN, James, Michael
IPC分类号： C07D231/38 , A61K31/415
CPC分类号： C07D231/38
摘要： The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or auto-immune conditions.
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公开(公告)号：EP2408769A1
公开(公告)日：2012-01-25
申请号：EP10709720.6
申请日：2010-03-15
申请人： Glaxo Group Limited
发明人： ALDER, Catherine, Mary , BALDWIN, Ian, Robert , BARTON, Nicholas, Paul , CAMPBELL, Amanda, Jennifer , CHAMPIGNY, Aurelie, Cecile , HARLING, John, David , MAXWELL, Aoife, Caitriona , SIMPSON, Juliet, Kay , SMITH, Ian, Edward, David , TAME, Christopher, John , WILSON, Caroline , WOOLVEN, James, Michael
IPC分类号： C07D417/12 , C07D417/14 , C07D513/04 , A61K31/04 , A61P11/06 , A61P29/00 , A61P37/00
CPC分类号： C07D513/04 , C07D417/12 , C07D417/14
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular ltk activity.
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3.发明授权PHENYL-PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORICOID RECEPTOR LIGANDS 有权苯基吡唑衍生物作为非甾体类糖皮质激素受体配体
公开(公告)号：EP2029549B1
公开(公告)日：2010-11-10
申请号：EP07765362.4
申请日：2007-06-11
申请人： Glaxo Group Limited
发明人： BARNETT, Heather, Anne , CAMPBELL, Ian, Baxter , COE, Diane, Mary , COOPER, Anthony, William, James , INGLIS, Graham, George, Adam , JONES, Haydn, Terence , KEELING, Steven, Philip , MACDONALD, Simon, John, Fawcett , MCLAY, Iain, McFarlane , SKONE, Philip, Alan , WEINGARTEN, Gordon, Gad , WOOLVEN, James, Michael
IPC分类号： C07D231/38 , A61K31/415
CPC分类号： C07D231/38
摘要： The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or auto-immune conditions.
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4.发明公开2-AMINO-4-(PYRIDIN-2-YL)-THIAZOLE DERIVATIVES AS TRANSFORMING GROWTH FACTOR BETA (TGF-BETA) INHIBITORS 审中-公开2-氨基-4-（吡啶-2-基）噻唑衍生物ALS抑制剂转化生长因子BET（TGF-βA）
公开(公告)号：EP1355892A1
公开(公告)日：2003-10-29
申请号：EP02710053.6
申请日：2002-01-30
申请人： GLAXO GROUP LIMITED
发明人： GELLIBERT, Francoise, Jeanne , HARTLEY, Charles, David , MATHEWS, Neil , WOOLVEN, James, Michael
IPC分类号： C07D277/42 , C07D417/14 , A61K31/425 , A61P1/16
CPC分类号： C07D417/14 , C07D471/04
摘要： Therapeutically active thiazole derivatives of formula (I) wherein R1, R2, X and X' are as defined in the specification, processes for the preparation thereof, the use thereof in therapy, particularly in the treatment or prophylaxis of disorders characterised by overexpression of transforming growth factor β (TGF-β), and pharmaceutical compositions for use in such therapy. (I)
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